Posterior Reversible Encephalopathy Syndrome and Azathioprine

Detalhes bibliográficos
Autor(a) principal: Vilas-Boas, S
Data de Publicação: 2019
Outros Autores: Corte-Real, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/2152
Resumo: Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. A 27-year-old woman, with mixed connective tissue disease under azathioprine, was admitted in the emergency room in status epilepticus and with severe hypertension. The MRI showed bilateral oedema in a pattern compatible with PRES. There was clinical improvement after azathioprine suspension. PRES is typically reversible with prompt recognition of the syndrome and its trigger. The association with azathioprine is rare. LEARNING POINTS: Posterior reversible encephalopathy syndrome should be considered in patients with sudden onset of headache, altered consciousness and seizures.Recognition of this entity and identification of the trigger are essential for reversal of the clinical picture.Autoimmune diseases and some immunosuppressive drugs have been identified as causative, but reports of an association with azathioprine are very rare.
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spelling Posterior Reversible Encephalopathy Syndrome and AzathioprinePosterior reversible encephalopathy syndromeAzathioprinePosterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. A 27-year-old woman, with mixed connective tissue disease under azathioprine, was admitted in the emergency room in status epilepticus and with severe hypertension. The MRI showed bilateral oedema in a pattern compatible with PRES. There was clinical improvement after azathioprine suspension. PRES is typically reversible with prompt recognition of the syndrome and its trigger. The association with azathioprine is rare. LEARNING POINTS: Posterior reversible encephalopathy syndrome should be considered in patients with sudden onset of headache, altered consciousness and seizures.Recognition of this entity and identification of the trigger are essential for reversal of the clinical picture.Autoimmune diseases and some immunosuppressive drugs have been identified as causative, but reports of an association with azathioprine are very rare.SMC MediaRepositório do Hospital Prof. Doutor Fernando FonsecaVilas-Boas, SCorte-Real, A2019-03-08T15:37:56Z2019-01-01T00:00:00Z2019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/2152engEur J Case Rep Intern Med. 2019 Jan 25;6(1):0010322284-259410.12890/2019_001032info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:51Zoai:repositorio.hff.min-saude.pt:10400.10/2152Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:53:08.111539Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Posterior Reversible Encephalopathy Syndrome and Azathioprine
title Posterior Reversible Encephalopathy Syndrome and Azathioprine
spellingShingle Posterior Reversible Encephalopathy Syndrome and Azathioprine
Vilas-Boas, S
Posterior reversible encephalopathy syndrome
Azathioprine
title_short Posterior Reversible Encephalopathy Syndrome and Azathioprine
title_full Posterior Reversible Encephalopathy Syndrome and Azathioprine
title_fullStr Posterior Reversible Encephalopathy Syndrome and Azathioprine
title_full_unstemmed Posterior Reversible Encephalopathy Syndrome and Azathioprine
title_sort Posterior Reversible Encephalopathy Syndrome and Azathioprine
author Vilas-Boas, S
author_facet Vilas-Boas, S
Corte-Real, A
author_role author
author2 Corte-Real, A
author2_role author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Vilas-Boas, S
Corte-Real, A
dc.subject.por.fl_str_mv Posterior reversible encephalopathy syndrome
Azathioprine
topic Posterior reversible encephalopathy syndrome
Azathioprine
description Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. A 27-year-old woman, with mixed connective tissue disease under azathioprine, was admitted in the emergency room in status epilepticus and with severe hypertension. The MRI showed bilateral oedema in a pattern compatible with PRES. There was clinical improvement after azathioprine suspension. PRES is typically reversible with prompt recognition of the syndrome and its trigger. The association with azathioprine is rare. LEARNING POINTS: Posterior reversible encephalopathy syndrome should be considered in patients with sudden onset of headache, altered consciousness and seizures.Recognition of this entity and identification of the trigger are essential for reversal of the clinical picture.Autoimmune diseases and some immunosuppressive drugs have been identified as causative, but reports of an association with azathioprine are very rare.
publishDate 2019
dc.date.none.fl_str_mv 2019-03-08T15:37:56Z
2019-01-01T00:00:00Z
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.10/2152
url http://hdl.handle.net/10400.10/2152
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Case Rep Intern Med. 2019 Jan 25;6(1):001032
2284-2594
10.12890/2019_001032
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dc.publisher.none.fl_str_mv SMC Media
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