Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus
Main Author: | |
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Publication Date: | 2012 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.17/724 |
Summary: | Fulminant myocarditis associated with influenza A virus is exceedingly rare, with only a few cases reported in the literature. We describe a previously healthy 10-year-old boy, with a three-day history of flu-like symptoms without antiviral treatment. He was hospitalized with dehydration and hypothermia in the context of persistent vomiting, when he suddenly developed heart failure secondary to fulminant myocarditis. Despite aggressive management, including circulatory support and cardiopulmonary resuscitation measures, the patient died of cardiogenic shock. The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement, and H1N1v polymerase chain reaction was positive. The prevalence of influenza-associated fulminant myocarditis remains unknown. Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains. |
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Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A VirusMiocardite Fulminante Associada ao Vírus Influenza A Pandémico H1N1Resultado FatalVírus da Gripe A, Subtipo H1N1Gripe HumanaMiocarditePandemiaFulminant myocarditis associated with influenza A virus is exceedingly rare, with only a few cases reported in the literature. We describe a previously healthy 10-year-old boy, with a three-day history of flu-like symptoms without antiviral treatment. He was hospitalized with dehydration and hypothermia in the context of persistent vomiting, when he suddenly developed heart failure secondary to fulminant myocarditis. Despite aggressive management, including circulatory support and cardiopulmonary resuscitation measures, the patient died of cardiogenic shock. The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement, and H1N1v polymerase chain reaction was positive. The prevalence of influenza-associated fulminant myocarditis remains unknown. Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains.Sociedade Portuguesa de CardiologiaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECabral, MBrito, MJConde, MOliveira, MCordeiro Ferreira, G2012-11-07T12:33:54Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/724engRev Port Cardiol. 2012 Jul-Aug;31(7-8):517-20info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:27:49Zoai:repositorio.chlc.min-saude.pt:10400.17/724Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:18:26.622927Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus Miocardite Fulminante Associada ao Vírus Influenza A Pandémico H1N1 |
title |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus |
spellingShingle |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus Cabral, M Resultado Fatal Vírus da Gripe A, Subtipo H1N1 Gripe Humana Miocardite Pandemia |
title_short |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus |
title_full |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus |
title_fullStr |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus |
title_full_unstemmed |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus |
title_sort |
Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus |
author |
Cabral, M |
author_facet |
Cabral, M Brito, MJ Conde, M Oliveira, M Cordeiro Ferreira, G |
author_role |
author |
author2 |
Brito, MJ Conde, M Oliveira, M Cordeiro Ferreira, G |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Cabral, M Brito, MJ Conde, M Oliveira, M Cordeiro Ferreira, G |
dc.subject.por.fl_str_mv |
Resultado Fatal Vírus da Gripe A, Subtipo H1N1 Gripe Humana Miocardite Pandemia |
topic |
Resultado Fatal Vírus da Gripe A, Subtipo H1N1 Gripe Humana Miocardite Pandemia |
description |
Fulminant myocarditis associated with influenza A virus is exceedingly rare, with only a few cases reported in the literature. We describe a previously healthy 10-year-old boy, with a three-day history of flu-like symptoms without antiviral treatment. He was hospitalized with dehydration and hypothermia in the context of persistent vomiting, when he suddenly developed heart failure secondary to fulminant myocarditis. Despite aggressive management, including circulatory support and cardiopulmonary resuscitation measures, the patient died of cardiogenic shock. The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement, and H1N1v polymerase chain reaction was positive. The prevalence of influenza-associated fulminant myocarditis remains unknown. Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11-07T12:33:54Z 2012 2012-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/724 |
url |
http://hdl.handle.net/10400.17/724 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rev Port Cardiol. 2012 Jul-Aug;31(7-8):517-20 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Cardiologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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