Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity

Detalhes bibliográficos
Autor(a) principal: Marques, M. P. M.
Data de Publicação: 2002
Outros Autores: Girão, T., Lima, Maria C. Pedroso de, Gameiro, A., Pereira, E., Garcia, P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/3882
https://doi.org/10.1016/S0167-4889(01)00186-0
Resumo: Cytotoxicity and cell growth inhibition studies were performed for three distinct polynuclear platinum(II) complexes of spermidine, which showed to have significant cytotoxic and antiproliferative properties on the HeLa cancer cell line. The chemical environment of the metal centres in the drugs, as well as the coordination pattern of the ligand, were found to be strongly determinant of their cytotoxic ability. In the light of the results gathered, the most effective anticancer compound among the ones tested (IC50=5 [mu]M) was found to be the one displaying three difunctional (PtCl2N2) moieties ((PtCl2)3(spd)2). Both the cytotoxic activity and the antiproliferative properties of the complexes studied showed to be irreversible for all the concentrations tested.
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spelling Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activityPlatinum complexSpermidineHeLa cellCytotoxicityAntitumor activityCytotoxicity and cell growth inhibition studies were performed for three distinct polynuclear platinum(II) complexes of spermidine, which showed to have significant cytotoxic and antiproliferative properties on the HeLa cancer cell line. The chemical environment of the metal centres in the drugs, as well as the coordination pattern of the ligand, were found to be strongly determinant of their cytotoxic ability. In the light of the results gathered, the most effective anticancer compound among the ones tested (IC50=5 [mu]M) was found to be the one displaying three difunctional (PtCl2N2) moieties ((PtCl2)3(spd)2). Both the cytotoxic activity and the antiproliferative properties of the complexes studied showed to be irreversible for all the concentrations tested.http://www.sciencedirect.com/science/article/B6T20-44P6YK2-3/1/19b22fc5d0627f0d3a6bc4000beb2fd42002info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/3882http://hdl.handle.net/10316/3882https://doi.org/10.1016/S0167-4889(01)00186-0engBiochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1589:1 (2002) 63-70Marques, M. P. M.Girão, T.Lima, Maria C. Pedroso deGameiro, A.Pereira, E.Garcia, P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-08-30T13:19:12Zoai:estudogeral.uc.pt:10316/3882Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:50.894936Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
title Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
spellingShingle Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
Marques, M. P. M.
Platinum complex
Spermidine
HeLa cell
Cytotoxicity
Antitumor activity
title_short Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
title_full Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
title_fullStr Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
title_full_unstemmed Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
title_sort Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity
author Marques, M. P. M.
author_facet Marques, M. P. M.
Girão, T.
Lima, Maria C. Pedroso de
Gameiro, A.
Pereira, E.
Garcia, P.
author_role author
author2 Girão, T.
Lima, Maria C. Pedroso de
Gameiro, A.
Pereira, E.
Garcia, P.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marques, M. P. M.
Girão, T.
Lima, Maria C. Pedroso de
Gameiro, A.
Pereira, E.
Garcia, P.
dc.subject.por.fl_str_mv Platinum complex
Spermidine
HeLa cell
Cytotoxicity
Antitumor activity
topic Platinum complex
Spermidine
HeLa cell
Cytotoxicity
Antitumor activity
description Cytotoxicity and cell growth inhibition studies were performed for three distinct polynuclear platinum(II) complexes of spermidine, which showed to have significant cytotoxic and antiproliferative properties on the HeLa cancer cell line. The chemical environment of the metal centres in the drugs, as well as the coordination pattern of the ligand, were found to be strongly determinant of their cytotoxic ability. In the light of the results gathered, the most effective anticancer compound among the ones tested (IC50=5 [mu]M) was found to be the one displaying three difunctional (PtCl2N2) moieties ((PtCl2)3(spd)2). Both the cytotoxic activity and the antiproliferative properties of the complexes studied showed to be irreversible for all the concentrations tested.
publishDate 2002
dc.date.none.fl_str_mv 2002
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/3882
http://hdl.handle.net/10316/3882
https://doi.org/10.1016/S0167-4889(01)00186-0
url http://hdl.handle.net/10316/3882
https://doi.org/10.1016/S0167-4889(01)00186-0
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1589:1 (2002) 63-70
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