Detalhes bibliográficos
| Autor(a) principal: |
Freitas,Roseana de Almeida |
| Data de Publicação: |
2010 |
| Outros Autores: |
Silveira,Ericka Janine Dantas,
Silveira,João Paulo Borges da,
Silva,Fabyanne Mazutti da,
Amorim,Rivadávio Fernandes Batista de |
| Tipo de documento: |
Artigo
|
| Idioma: |
eng |
| Título da fonte: |
Acta Cirúrgica Brasileira (Online) |
| Texto Completo: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000600010
|
Resumo: |
PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC of the tongue and its correlation with tumor metastasis. METHODS: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the β-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). RESULTS: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. CONCLUSIONS: Based on these results, it can be concluded that the immunoexpression of β-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue. |