Comparative study of suture and cyanoacrylates in skin closure of rats
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400013 |
Resumo: | PURPOSE: To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. METHODS: Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the 3rd, 7th, 14th or 21st post-operative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis. RESULTS: The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures. CONCLUSION: ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications. |
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Acta Cirúrgica Brasileira (Online) |
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Comparative study of suture and cyanoacrylates in skin closure of ratsTissue adhesivesCyanoacrylatesMaterials TestingRatsPURPOSE: To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. METHODS: Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the 3rd, 7th, 14th or 21st post-operative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis. RESULTS: The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures. CONCLUSION: ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2007-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400013Acta Cirúrgica Brasileira v.22 n.4 2007reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502007000400013info:eu-repo/semantics/openAccessSouza,Sandro Cilindro deOliveira,Washington Luiz deSoares,Dario Fernando de Oliveira SantosBriglia,Carlos HenriqueAthanázio,Paulo RobertoCerqueira,Martins Dias deGuimarães,Pedro HamiltonCarreiro,Mário Castroeng2007-07-23T00:00:00Zoai:scielo:S0102-86502007000400013Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-07-23T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Comparative study of suture and cyanoacrylates in skin closure of rats |
title |
Comparative study of suture and cyanoacrylates in skin closure of rats |
spellingShingle |
Comparative study of suture and cyanoacrylates in skin closure of rats Souza,Sandro Cilindro de Tissue adhesives Cyanoacrylates Materials Testing Rats |
title_short |
Comparative study of suture and cyanoacrylates in skin closure of rats |
title_full |
Comparative study of suture and cyanoacrylates in skin closure of rats |
title_fullStr |
Comparative study of suture and cyanoacrylates in skin closure of rats |
title_full_unstemmed |
Comparative study of suture and cyanoacrylates in skin closure of rats |
title_sort |
Comparative study of suture and cyanoacrylates in skin closure of rats |
author |
Souza,Sandro Cilindro de |
author_facet |
Souza,Sandro Cilindro de Oliveira,Washington Luiz de Soares,Dario Fernando de Oliveira Santos Briglia,Carlos Henrique Athanázio,Paulo Roberto Cerqueira,Martins Dias de Guimarães,Pedro Hamilton Carreiro,Mário Castro |
author_role |
author |
author2 |
Oliveira,Washington Luiz de Soares,Dario Fernando de Oliveira Santos Briglia,Carlos Henrique Athanázio,Paulo Roberto Cerqueira,Martins Dias de Guimarães,Pedro Hamilton Carreiro,Mário Castro |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza,Sandro Cilindro de Oliveira,Washington Luiz de Soares,Dario Fernando de Oliveira Santos Briglia,Carlos Henrique Athanázio,Paulo Roberto Cerqueira,Martins Dias de Guimarães,Pedro Hamilton Carreiro,Mário Castro |
dc.subject.por.fl_str_mv |
Tissue adhesives Cyanoacrylates Materials Testing Rats |
topic |
Tissue adhesives Cyanoacrylates Materials Testing Rats |
description |
PURPOSE: To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. METHODS: Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the 3rd, 7th, 14th or 21st post-operative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis. RESULTS: The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures. CONCLUSION: ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000400013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502007000400013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.22 n.4 2007 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126438676365312 |