Therapeutic benefits of Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T.D. Penn., Sapotaceae, in experimental models of pain and inflammation

• Autor(a) principal: Araujo-Neto,Vitor
• Data de Publicação: 2010
• Outros Autores: Bomfim,Rangel R, Oliveira,Valter O. B, Passos,Ailane M. P. R, Oliveira,Juliana P. R, Lima,Clésio A, Mendes,Sandra S, Estevam,Charles S, Thomazzi,Sara M
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000600018
• topic: anti-inflammatory; antinociceptive; Sideroxylon obtusifolium; Sapotaceae

Sideroxylon obtusifolium (Humb. ex Roem. &amp; Schult.) T.D. Penn., Sapotaceae, is a plant with analgesic and anti-inflammatory activities used in folk medicine. In order to evaluate the actions of this plant, studies were performed on antinociceptive and anti-inflammatory activities with the ethanol extract (EE) of inner bark (100-400 mg/kg). Oral treatment with the EE elicited inhibitory activity (200 and 400 mg/kg, p<0.01) on acetic acid effect and reduced (100, 200, and 400 mg/kg, p<0.001) the formalin effect at the second-phase, however it did not elicit any inhibitory effect on hot-plate test. Carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity were reduced with the EE at 100, 200, and 400 mg/kg (p<0.001). In conclusion, the EE of Sideroxylon obtusifolium shows antinociceptive and anti-inflammatory activities, supporting the folkloric usage of the plant to treat pain and various inflammatory diseases.