Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models

Detalhes bibliográficos
Autor(a) principal: Santos,Vanda Lucia dos
Data de Publicação: 2007
Outros Autores: Costa,Viviam Bruna Machado, Agra,Maria de Fátima, Silva,Bagnólia Araújo da, Batista,Leônia Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000300006
Resumo: The crude ethanol extract (EEOH) of the bark of Maytenus rigida Mart (Celastraceae) a plant used in Brazil herbal traditional medicine, was tested for anti-inflammatory, antiulcer and antidiarrhoeal activities in animal models. No acute toxicological sign was observed in animals treated with the highest dose (5000 mg/kg, p.o. or 2000 mg/kg i.p.) of EEOH. The extract doses of 250, 500 or 750 mg/kg revealed a significant inhibitory effect (P < 0,01) in carrageenin-induced rat paw oedema and exhibited ulcer-protective properties against ethanol-induced ulceration in rats. An anti-diarrhoeal activity (P < 0.01) was also observed in castor-oil-induced diarrhoeal in mice. The intestinal transit was significantly (P < 0.01) reduced, however the pretreatment did not reduce the weight of intestinal contents. These results support the popular applications of Maytenus rigida for the treatment of inflammation, ulcer and diarrhoea in Brazil herbal traditional medicine.
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spelling Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal modelsMaytenus rigidaCelastraceaeanti-inflammatoryantiulceranti-diarrhoealThe crude ethanol extract (EEOH) of the bark of Maytenus rigida Mart (Celastraceae) a plant used in Brazil herbal traditional medicine, was tested for anti-inflammatory, antiulcer and antidiarrhoeal activities in animal models. No acute toxicological sign was observed in animals treated with the highest dose (5000 mg/kg, p.o. or 2000 mg/kg i.p.) of EEOH. The extract doses of 250, 500 or 750 mg/kg revealed a significant inhibitory effect (P < 0,01) in carrageenin-induced rat paw oedema and exhibited ulcer-protective properties against ethanol-induced ulceration in rats. An anti-diarrhoeal activity (P < 0.01) was also observed in castor-oil-induced diarrhoeal in mice. The intestinal transit was significantly (P < 0.01) reduced, however the pretreatment did not reduce the weight of intestinal contents. These results support the popular applications of Maytenus rigida for the treatment of inflammation, ulcer and diarrhoea in Brazil herbal traditional medicine.Sociedade Brasileira de Farmacognosia2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000300006Revista Brasileira de Farmacognosia v.17 n.3 2007reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2007000300006info:eu-repo/semantics/openAccessSantos,Vanda Lucia dosCosta,Viviam Bruna MachadoAgra,Maria de FátimaSilva,Bagnólia Araújo daBatista,Leônia Mariaeng2007-10-11T00:00:00Zoai:scielo:S0102-695X2007000300006Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2007-10-11T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
title Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
spellingShingle Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
Santos,Vanda Lucia dos
Maytenus rigida
Celastraceae
anti-inflammatory
antiulcer
anti-diarrhoeal
title_short Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
title_full Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
title_fullStr Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
title_full_unstemmed Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
title_sort Pharmacological studies of ethanolic extracts of Maytenus rigida Mart (Celastraceae) in animal models
author Santos,Vanda Lucia dos
author_facet Santos,Vanda Lucia dos
Costa,Viviam Bruna Machado
Agra,Maria de Fátima
Silva,Bagnólia Araújo da
Batista,Leônia Maria
author_role author
author2 Costa,Viviam Bruna Machado
Agra,Maria de Fátima
Silva,Bagnólia Araújo da
Batista,Leônia Maria
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos,Vanda Lucia dos
Costa,Viviam Bruna Machado
Agra,Maria de Fátima
Silva,Bagnólia Araújo da
Batista,Leônia Maria
dc.subject.por.fl_str_mv Maytenus rigida
Celastraceae
anti-inflammatory
antiulcer
anti-diarrhoeal
topic Maytenus rigida
Celastraceae
anti-inflammatory
antiulcer
anti-diarrhoeal
description The crude ethanol extract (EEOH) of the bark of Maytenus rigida Mart (Celastraceae) a plant used in Brazil herbal traditional medicine, was tested for anti-inflammatory, antiulcer and antidiarrhoeal activities in animal models. No acute toxicological sign was observed in animals treated with the highest dose (5000 mg/kg, p.o. or 2000 mg/kg i.p.) of EEOH. The extract doses of 250, 500 or 750 mg/kg revealed a significant inhibitory effect (P < 0,01) in carrageenin-induced rat paw oedema and exhibited ulcer-protective properties against ethanol-induced ulceration in rats. An anti-diarrhoeal activity (P < 0.01) was also observed in castor-oil-induced diarrhoeal in mice. The intestinal transit was significantly (P < 0.01) reduced, however the pretreatment did not reduce the weight of intestinal contents. These results support the popular applications of Maytenus rigida for the treatment of inflammation, ulcer and diarrhoea in Brazil herbal traditional medicine.
publishDate 2007
dc.date.none.fl_str_mv 2007-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2007000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2007000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.17 n.3 2007
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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