Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/1645 |
Resumo: | Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5% (GS5%) and 10% (GS10%), comparing their effects with doxycycline gel at 10% (D10%, positive control), vehicle gel (negative control) and a group with experimental periodontal disease, but non-treated. The gels were locally applied in the gingival region immediately after the experimental periodontal disease induction by ligature (3×/day, 11 days). Bone destruction was determined through clinical exam, histopathological analysis and cone beam computed tomography of the experimental animals (n = 36). After 11 days of periodontitis induction, all groups that received ligature presented a decrease in the corporal mass, except to the naïve group (without experimental periodontal disease) (p < 0.05). Computed tomography results have shown healthy bone structure in the group I and bone resorption for the test groups. Histopathological analysis confirmed the healthy bone structure for naïve group animals, while the test groups exhibited bone loss in several degrees. In particular, the non-treated group animals had an intense inflammatory process. When the periodontium of the animals treated with GS10% was histopathologically analyzed, insertion periodontium was preserved. The results for these groups were significantly different of the vehicle group (p < 0.05). According to the results, the gel based in the aqueous extract of H. pectinata at 10% can prevent bone loss in experimental periodontal disease similarly to doxycycline 10%. |
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Paixão, Mônica SilveiraMelo, Mônica Santos deDamascena, Nicole PrataAraujo, Adriano Antunes de SouzaSoares, Andrea FerreiraOliveira, Denise V. A.Oliveira, Jeison Saturnino deAlmeida, Fabrício Tavares Cunha deSilva, Francilene Amaral daAraujo, Brancilene Santos deEstevam, Charles dos SantosSoares, Marco Antonio BotelhoQuintans-Júnior, Lucindo José2016-02-17T14:24:14Z2016-02-17T14:24:14Z2015-02PAIXÃO, M. S. et al. Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats. Revista Brasileira de Farmacognosia, Curitiba, v. 25, n. 1, jan./fev. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100035&lng=en&nrm=iso&tlng=en>. Acesso em: 17 fev. 2016.0102-695Xhttps://ri.ufs.br/handle/riufs/1645Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalHyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5% (GS5%) and 10% (GS10%), comparing their effects with doxycycline gel at 10% (D10%, positive control), vehicle gel (negative control) and a group with experimental periodontal disease, but non-treated. The gels were locally applied in the gingival region immediately after the experimental periodontal disease induction by ligature (3×/day, 11 days). Bone destruction was determined through clinical exam, histopathological analysis and cone beam computed tomography of the experimental animals (n = 36). After 11 days of periodontitis induction, all groups that received ligature presented a decrease in the corporal mass, except to the naïve group (without experimental periodontal disease) (p < 0.05). Computed tomography results have shown healthy bone structure in the group I and bone resorption for the test groups. Histopathological analysis confirmed the healthy bone structure for naïve group animals, while the test groups exhibited bone loss in several degrees. In particular, the non-treated group animals had an intense inflammatory process. When the periodontium of the animals treated with GS10% was histopathologically analyzed, insertion periodontium was preserved. The results for these groups were significantly different of the vehicle group (p < 0.05). According to the results, the gel based in the aqueous extract of H. pectinata at 10% can prevent bone loss in experimental periodontal disease similarly to doxycycline 10%.Universidade Federal do Paraná, Laboratório de FarmacognosiaHyptis pectinataPeriodontitisBone lossDoxycyclineHyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILHyptisPectinataPeriodontitis.pdf.jpgHyptisPectinataPeriodontitis.pdf.jpgGenerated Thumbnailimage/jpeg1688https://ri.ufs.br/jspui/bitstream/riufs/1645/4/HyptisPectinataPeriodontitis.pdf.jpg591d28f9ad2ffa6374a54d6ff3de3d67MD54ORIGINALHyptisPectinataPeriodontitis.pdfHyptisPectinataPeriodontitis.pdfapplication/pdf1411728https://ri.ufs.br/jspui/bitstream/riufs/1645/1/HyptisPectinataPeriodontitis.pdfba46ee93c2e4e9ccef959fce5e17f839MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1645/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTHyptisPectinataPeriodontitis.pdf.txtHyptisPectinataPeriodontitis.pdf.txtExtracted texttext/plain42953https://ri.ufs.br/jspui/bitstream/riufs/1645/3/HyptisPectinataPeriodontitis.pdf.txtf4775b6bab51864b8e80a5732b60f1d5MD53riufs/16452016-07-29 20:59:09.567oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2016-07-29T23:59:09Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
title |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
spellingShingle |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats Paixão, Mônica Silveira Hyptis pectinata Periodontitis Bone loss Doxycycline |
title_short |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
title_full |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
title_fullStr |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
title_full_unstemmed |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
title_sort |
Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats |
author |
Paixão, Mônica Silveira |
author_facet |
Paixão, Mônica Silveira Melo, Mônica Santos de Damascena, Nicole Prata Araujo, Adriano Antunes de Souza Soares, Andrea Ferreira Oliveira, Denise V. A. Oliveira, Jeison Saturnino de Almeida, Fabrício Tavares Cunha de Silva, Francilene Amaral da Araujo, Brancilene Santos de Estevam, Charles dos Santos Soares, Marco Antonio Botelho Quintans-Júnior, Lucindo José |
author_role |
author |
author2 |
Melo, Mônica Santos de Damascena, Nicole Prata Araujo, Adriano Antunes de Souza Soares, Andrea Ferreira Oliveira, Denise V. A. Oliveira, Jeison Saturnino de Almeida, Fabrício Tavares Cunha de Silva, Francilene Amaral da Araujo, Brancilene Santos de Estevam, Charles dos Santos Soares, Marco Antonio Botelho Quintans-Júnior, Lucindo José |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paixão, Mônica Silveira Melo, Mônica Santos de Damascena, Nicole Prata Araujo, Adriano Antunes de Souza Soares, Andrea Ferreira Oliveira, Denise V. A. Oliveira, Jeison Saturnino de Almeida, Fabrício Tavares Cunha de Silva, Francilene Amaral da Araujo, Brancilene Santos de Estevam, Charles dos Santos Soares, Marco Antonio Botelho Quintans-Júnior, Lucindo José |
dc.subject.por.fl_str_mv |
Hyptis pectinata Periodontitis Bone loss Doxycycline |
topic |
Hyptis pectinata Periodontitis Bone loss Doxycycline |
description |
Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5% (GS5%) and 10% (GS10%), comparing their effects with doxycycline gel at 10% (D10%, positive control), vehicle gel (negative control) and a group with experimental periodontal disease, but non-treated. The gels were locally applied in the gingival region immediately after the experimental periodontal disease induction by ligature (3×/day, 11 days). Bone destruction was determined through clinical exam, histopathological analysis and cone beam computed tomography of the experimental animals (n = 36). After 11 days of periodontitis induction, all groups that received ligature presented a decrease in the corporal mass, except to the naïve group (without experimental periodontal disease) (p < 0.05). Computed tomography results have shown healthy bone structure in the group I and bone resorption for the test groups. Histopathological analysis confirmed the healthy bone structure for naïve group animals, while the test groups exhibited bone loss in several degrees. In particular, the non-treated group animals had an intense inflammatory process. When the periodontium of the animals treated with GS10% was histopathologically analyzed, insertion periodontium was preserved. The results for these groups were significantly different of the vehicle group (p < 0.05). According to the results, the gel based in the aqueous extract of H. pectinata at 10% can prevent bone loss in experimental periodontal disease similarly to doxycycline 10%. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-02 |
dc.date.accessioned.fl_str_mv |
2016-02-17T14:24:14Z |
dc.date.available.fl_str_mv |
2016-02-17T14:24:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAIXÃO, M. S. et al. Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats. Revista Brasileira de Farmacognosia, Curitiba, v. 25, n. 1, jan./fev. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100035&lng=en&nrm=iso&tlng=en>. Acesso em: 17 fev. 2016. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/1645 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
identifier_str_mv |
PAIXÃO, M. S. et al. Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats. Revista Brasileira de Farmacognosia, Curitiba, v. 25, n. 1, jan./fev. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100035&lng=en&nrm=iso&tlng=en>. Acesso em: 17 fev. 2016. 0102-695X Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
url |
https://ri.ufs.br/handle/riufs/1645 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Paraná, Laboratório de Farmacognosia |
publisher.none.fl_str_mv |
Universidade Federal do Paraná, Laboratório de Farmacognosia |
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reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
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Universidade Federal de Sergipe (UFS) |
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UFS |
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UFS |
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Repositório Institucional da UFS |
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Repositório Institucional da UFS |
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