Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/1416 |
Resumo: | Dengue fever and schistosomiasis are major public health issues for which vector control using larvicide and molluscicide substances present in plants provides a promising strategy. This study evaluated the potential toxicity of the extract of hydroethanol Schinopsis brasiliensis Engl., Anacardiaceae, stem bark and its chloroform, hexane, ethyl acetate, and hydromethanol fractions against Artemia salina and Aedes Aegypti larvae and snails Biomphalaria glabrata. All of the assays were performed in triplicate and the mean mortality rates were used to determine the LC50 and LC90 values using the probit method. The hydroethanol hydromethanol extract and fraction were free of toxicity towards A. salina (LC50 > 1000 µg/ml), while chloroform fraction was moderately toxic (LC50 313 µg/ml); ethyl acetate and hexane fractions displayed low toxicity, with LC50 557 and 582 µg/ml, respectively. Chloroform, hexane, and ethyl acetate fractions showed larvicidal potential towards A. aegypti (LC50 values of 345, 527 and 583 µg/ml, respectively), while chloroform and ethyl acetate fractions were highly toxic to B. glabrata (LC90 values of 68 and 73 µg/ml, respectively). Based on these findings, ethyl acetate, chloroform, and hexane fractions should be further investigated for their potential use against the vectors of dengue and schistosomiasis. |
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Dias, Antônio SantosSantos, Clisiane Carla de SouzaAraujo, Silvan Silva deSantos, André Luiz Lima Menezes dosAlmeida, Elis Cristiane Valença deDamascena, Nicole PrataSantos, Deisylaine Maria dosSantos, Matheus Ismerim SilvaRibeiro Júnior, Karlos Antônio LisboaPereira, Carla Karine BarbosaLima, Amanda do Carmo Bion deShan, Andrea Yu Kwan VillarSantana, Antônio Euzébio GoulartEstevam, Charles dos SantosAraujo, Brancilene Santos de2015-01-29T21:32:40Z2015-01-29T21:32:40Z2014-06SANTOS, C. C. S. et. al. Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions. Revista Brasileira de Farmacognosia, Curitiba, v. 24, n. 3, maio/jun. 2014. Disponível em: <http://www.scielo.br/scielo.php?pid=S0102-695X2014000300298&script=sci_arttext>. Acesso em: 29 jan. 2015.0102-695Xhttps://ri.ufs.br/handle/riufs/1416Creative Commons Attribution LicenseDengue fever and schistosomiasis are major public health issues for which vector control using larvicide and molluscicide substances present in plants provides a promising strategy. This study evaluated the potential toxicity of the extract of hydroethanol Schinopsis brasiliensis Engl., Anacardiaceae, stem bark and its chloroform, hexane, ethyl acetate, and hydromethanol fractions against Artemia salina and Aedes Aegypti larvae and snails Biomphalaria glabrata. All of the assays were performed in triplicate and the mean mortality rates were used to determine the LC50 and LC90 values using the probit method. The hydroethanol hydromethanol extract and fraction were free of toxicity towards A. salina (LC50 > 1000 µg/ml), while chloroform fraction was moderately toxic (LC50 313 µg/ml); ethyl acetate and hexane fractions displayed low toxicity, with LC50 557 and 582 µg/ml, respectively. Chloroform, hexane, and ethyl acetate fractions showed larvicidal potential towards A. aegypti (LC50 values of 345, 527 and 583 µg/ml, respectively), while chloroform and ethyl acetate fractions were highly toxic to B. glabrata (LC90 values of 68 and 73 µg/ml, respectively). Based on these findings, ethyl acetate, chloroform, and hexane fractions should be further investigated for their potential use against the vectors of dengue and schistosomiasis.Sociedade Brasileira de FarmacognosiaArtemia salinaErythrina velutinaFabaceaLarvicidasMoluscicidaSchinopsis brasiliensisAnalgésicosEvaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILEvaluationToxicity.pdf.jpgEvaluationToxicity.pdf.jpgGenerated Thumbnailimage/jpeg1801https://ri.ufs.br/jspui/bitstream/riufs/1416/6/EvaluationToxicity.pdf.jpg85252d0d36eb0be47f8999d989f90d76MD56ORIGINALEvaluationToxicity.pdfEvaluationToxicity.pdfapplication/pdf752026https://ri.ufs.br/jspui/bitstream/riufs/1416/4/EvaluationToxicity.pdf05f213e4b7089e8ec916e68cf98bb209MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1416/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTInvestigationOfProtective.pdf.txtInvestigationOfProtective.pdf.txtExtracted texttext/plain26342https://ri.ufs.br/jspui/bitstream/riufs/1416/3/InvestigationOfProtective.pdf.txt27e4063a8cfb196890a849fb3a171dddMD53EvaluationToxicity.pdf.txtEvaluationToxicity.pdf.txtExtracted texttext/plain28239https://ri.ufs.br/jspui/bitstream/riufs/1416/5/EvaluationToxicity.pdf.txt7e67c50147af367751acba34c4adbec5MD55riufs/14162016-01-14 18:53:09.384oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2016-01-14T21:53:09Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
title |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
spellingShingle |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions Dias, Antônio Santos Artemia salina Erythrina velutina Fabacea Larvicidas Moluscicida Schinopsis brasiliensis Analgésicos |
title_short |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
title_full |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
title_fullStr |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
title_full_unstemmed |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
title_sort |
Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions |
author |
Dias, Antônio Santos |
author_facet |
Dias, Antônio Santos Santos, Clisiane Carla de Souza Araujo, Silvan Silva de Santos, André Luiz Lima Menezes dos Almeida, Elis Cristiane Valença de Damascena, Nicole Prata Santos, Deisylaine Maria dos Santos, Matheus Ismerim Silva Ribeiro Júnior, Karlos Antônio Lisboa Pereira, Carla Karine Barbosa Lima, Amanda do Carmo Bion de Shan, Andrea Yu Kwan Villar Santana, Antônio Euzébio Goulart Estevam, Charles dos Santos Araujo, Brancilene Santos de |
author_role |
author |
author2 |
Santos, Clisiane Carla de Souza Araujo, Silvan Silva de Santos, André Luiz Lima Menezes dos Almeida, Elis Cristiane Valença de Damascena, Nicole Prata Santos, Deisylaine Maria dos Santos, Matheus Ismerim Silva Ribeiro Júnior, Karlos Antônio Lisboa Pereira, Carla Karine Barbosa Lima, Amanda do Carmo Bion de Shan, Andrea Yu Kwan Villar Santana, Antônio Euzébio Goulart Estevam, Charles dos Santos Araujo, Brancilene Santos de |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dias, Antônio Santos Santos, Clisiane Carla de Souza Araujo, Silvan Silva de Santos, André Luiz Lima Menezes dos Almeida, Elis Cristiane Valença de Damascena, Nicole Prata Santos, Deisylaine Maria dos Santos, Matheus Ismerim Silva Ribeiro Júnior, Karlos Antônio Lisboa Pereira, Carla Karine Barbosa Lima, Amanda do Carmo Bion de Shan, Andrea Yu Kwan Villar Santana, Antônio Euzébio Goulart Estevam, Charles dos Santos Araujo, Brancilene Santos de |
dc.subject.por.fl_str_mv |
Artemia salina Erythrina velutina Fabacea Larvicidas Moluscicida Schinopsis brasiliensis Analgésicos |
topic |
Artemia salina Erythrina velutina Fabacea Larvicidas Moluscicida Schinopsis brasiliensis Analgésicos |
description |
Dengue fever and schistosomiasis are major public health issues for which vector control using larvicide and molluscicide substances present in plants provides a promising strategy. This study evaluated the potential toxicity of the extract of hydroethanol Schinopsis brasiliensis Engl., Anacardiaceae, stem bark and its chloroform, hexane, ethyl acetate, and hydromethanol fractions against Artemia salina and Aedes Aegypti larvae and snails Biomphalaria glabrata. All of the assays were performed in triplicate and the mean mortality rates were used to determine the LC50 and LC90 values using the probit method. The hydroethanol hydromethanol extract and fraction were free of toxicity towards A. salina (LC50 > 1000 µg/ml), while chloroform fraction was moderately toxic (LC50 313 µg/ml); ethyl acetate and hexane fractions displayed low toxicity, with LC50 557 and 582 µg/ml, respectively. Chloroform, hexane, and ethyl acetate fractions showed larvicidal potential towards A. aegypti (LC50 values of 345, 527 and 583 µg/ml, respectively), while chloroform and ethyl acetate fractions were highly toxic to B. glabrata (LC90 values of 68 and 73 µg/ml, respectively). Based on these findings, ethyl acetate, chloroform, and hexane fractions should be further investigated for their potential use against the vectors of dengue and schistosomiasis. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-06 |
dc.date.accessioned.fl_str_mv |
2015-01-29T21:32:40Z |
dc.date.available.fl_str_mv |
2015-01-29T21:32:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, C. C. S. et. al. Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions. Revista Brasileira de Farmacognosia, Curitiba, v. 24, n. 3, maio/jun. 2014. Disponível em: <http://www.scielo.br/scielo.php?pid=S0102-695X2014000300298&script=sci_arttext>. Acesso em: 29 jan. 2015. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/1416 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution License |
identifier_str_mv |
SANTOS, C. C. S. et. al. Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions. Revista Brasileira de Farmacognosia, Curitiba, v. 24, n. 3, maio/jun. 2014. Disponível em: <http://www.scielo.br/scielo.php?pid=S0102-695X2014000300298&script=sci_arttext>. Acesso em: 29 jan. 2015. 0102-695X Creative Commons Attribution License |
url |
https://ri.ufs.br/handle/riufs/1416 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
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Universidade Federal de Sergipe (UFS) |
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Repositório Institucional da UFS |
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