The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts

Detalhes bibliográficos
Autor(a) principal: Wohlfahrt,Aline B.
Data de Publicação: 2015
Outros Autores: Hannel,Laura, Oliveira,Liliane Z., Soares,Pâmela B., Silva,José Edson P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007
Resumo: Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme.
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spelling The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblastshematogonesB lymphoblastsacute lymphoblastic leukemiaflow cytometryimmunophenotypingHematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme.Sociedade Brasileira de Patologia Clínica2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007Jornal Brasileiro de Patologia e Medicina Laboratorial v.51 n.1 2015reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20150002info:eu-repo/semantics/openAccessWohlfahrt,Aline B.Hannel,LauraOliveira,Liliane Z.Soares,Pâmela B.Silva,José Edson P.eng2015-05-14T00:00:00Zoai:scielo:S1676-24442015000100007Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2015-05-14T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
title The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
spellingShingle The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
Wohlfahrt,Aline B.
hematogones
B lymphoblasts
acute lymphoblastic leukemia
flow cytometry
immunophenotyping
title_short The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
title_full The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
title_fullStr The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
title_full_unstemmed The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
title_sort The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
author Wohlfahrt,Aline B.
author_facet Wohlfahrt,Aline B.
Hannel,Laura
Oliveira,Liliane Z.
Soares,Pâmela B.
Silva,José Edson P.
author_role author
author2 Hannel,Laura
Oliveira,Liliane Z.
Soares,Pâmela B.
Silva,José Edson P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Wohlfahrt,Aline B.
Hannel,Laura
Oliveira,Liliane Z.
Soares,Pâmela B.
Silva,José Edson P.
dc.subject.por.fl_str_mv hematogones
B lymphoblasts
acute lymphoblastic leukemia
flow cytometry
immunophenotyping
topic hematogones
B lymphoblasts
acute lymphoblastic leukemia
flow cytometry
immunophenotyping
description Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme.
publishDate 2015
dc.date.none.fl_str_mv 2015-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20150002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.51 n.1 2015
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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