Molecular analysis of translocations associated with Ewing sarcoma: case report

Detalhes bibliográficos
Autor(a) principal: Soares,Leonardo R.
Data de Publicação: 2019
Outros Autores: Bayeh,Hugo A., Albuquerque,Izabela Cristina, Moreira,Marise A. R., Coutinho,Miguel A. C., Rodrigues,Debora F., Queiroz,Paula O. C., Freitas-Junior,Ruffo
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000200218
Resumo: ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation.
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spelling Molecular analysis of translocations associated with Ewing sarcoma: case reportbreast neoplasmspathologyEwing sarcomaABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation.Sociedade Brasileira de Patologia Clínica2019-04-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000200218Jornal Brasileiro de Patologia e Medicina Laboratorial v.55 n.2 2019reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20190020info:eu-repo/semantics/openAccessSoares,Leonardo R.Bayeh,Hugo A.Albuquerque,Izabela CristinaMoreira,Marise A. R.Coutinho,Miguel A. C.Rodrigues,Debora F.Queiroz,Paula O. C.Freitas-Junior,Ruffoeng2019-05-21T00:00:00Zoai:scielo:S1676-24442019000200218Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2019-05-21T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Molecular analysis of translocations associated with Ewing sarcoma: case report
title Molecular analysis of translocations associated with Ewing sarcoma: case report
spellingShingle Molecular analysis of translocations associated with Ewing sarcoma: case report
Soares,Leonardo R.
breast neoplasms
pathology
Ewing sarcoma
title_short Molecular analysis of translocations associated with Ewing sarcoma: case report
title_full Molecular analysis of translocations associated with Ewing sarcoma: case report
title_fullStr Molecular analysis of translocations associated with Ewing sarcoma: case report
title_full_unstemmed Molecular analysis of translocations associated with Ewing sarcoma: case report
title_sort Molecular analysis of translocations associated with Ewing sarcoma: case report
author Soares,Leonardo R.
author_facet Soares,Leonardo R.
Bayeh,Hugo A.
Albuquerque,Izabela Cristina
Moreira,Marise A. R.
Coutinho,Miguel A. C.
Rodrigues,Debora F.
Queiroz,Paula O. C.
Freitas-Junior,Ruffo
author_role author
author2 Bayeh,Hugo A.
Albuquerque,Izabela Cristina
Moreira,Marise A. R.
Coutinho,Miguel A. C.
Rodrigues,Debora F.
Queiroz,Paula O. C.
Freitas-Junior,Ruffo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares,Leonardo R.
Bayeh,Hugo A.
Albuquerque,Izabela Cristina
Moreira,Marise A. R.
Coutinho,Miguel A. C.
Rodrigues,Debora F.
Queiroz,Paula O. C.
Freitas-Junior,Ruffo
dc.subject.por.fl_str_mv breast neoplasms
pathology
Ewing sarcoma
topic breast neoplasms
pathology
Ewing sarcoma
description ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000200218
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000200218
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20190020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.55 n.2 2019
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
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reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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