Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000100058 |
Resumo: | OBJECTIVE: To determine the frequency of different phenotypes for congenital anomalies of the kidney and urinary tract (CAKUT) in a Brazilian sample, and to evaluate the association between the CAKUT phenotypes and the BMP4 gene. METHODS: In this study, 457 Brazilian individuals were analyzed in an attempt to establish the association between the BMP4 gene and the CAKUT diagnosis. A case-control sample was genotyped for three BMP4 gene polymorphisms. RESULTS: Association data was established with CAKUT sample as a whole and with the three most important CAKUT phenotypes: multicystic dysplastic kidney disease (MDK), ureteropelvic junction obstruction (UPJO) and vesicoureteral reflux (VUR). When the sample was segregated in these three phenotypes, associations between the BMP4 gene were observed with UPJO and with MDK. Conversely, VUR was not associated to the polymorphisms of the BMP4 gene. CONCLUSIONS: The present data suggest that Brazilian individuals with polymorphisms of the BMP4 gene have a higher risk to develop CAKUT, especially the malformations related to nephrogenesis and initial branching such as MDK and UPJO. Conversely, VUR appeared not to be related to BMP4 gene. |
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Jornal de Pediatria (Online) |
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Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tractAssociation studyBMP4Congenital anomalies of the kidney and urinary tractCAKUT OBJECTIVE: To determine the frequency of different phenotypes for congenital anomalies of the kidney and urinary tract (CAKUT) in a Brazilian sample, and to evaluate the association between the CAKUT phenotypes and the BMP4 gene. METHODS: In this study, 457 Brazilian individuals were analyzed in an attempt to establish the association between the BMP4 gene and the CAKUT diagnosis. A case-control sample was genotyped for three BMP4 gene polymorphisms. RESULTS: Association data was established with CAKUT sample as a whole and with the three most important CAKUT phenotypes: multicystic dysplastic kidney disease (MDK), ureteropelvic junction obstruction (UPJO) and vesicoureteral reflux (VUR). When the sample was segregated in these three phenotypes, associations between the BMP4 gene were observed with UPJO and with MDK. Conversely, VUR was not associated to the polymorphisms of the BMP4 gene. CONCLUSIONS: The present data suggest that Brazilian individuals with polymorphisms of the BMP4 gene have a higher risk to develop CAKUT, especially the malformations related to nephrogenesis and initial branching such as MDK and UPJO. Conversely, VUR appeared not to be related to BMP4 gene. Sociedade Brasileira de Pediatria2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000100058Jornal de Pediatria v.90 n.1 2014reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2013.06.004info:eu-repo/semantics/openAccessReis,Geisilaine Soares dosSilva,Ana Cristina Simões eFreitas,Izabella SilvaHeilbuth,Thiago RamosMarco,Luiz Armando deOliveira,Eduardo AraújoMiranda,Débora Marqueseng2015-08-28T00:00:00Zoai:scielo:S0021-75572014000100058Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2015-08-28T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
title |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
spellingShingle |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract Reis,Geisilaine Soares dos Association study BMP4 Congenital anomalies of the kidney and urinary tract CAKUT |
title_short |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
title_full |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
title_fullStr |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
title_full_unstemmed |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
title_sort |
Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract |
author |
Reis,Geisilaine Soares dos |
author_facet |
Reis,Geisilaine Soares dos Silva,Ana Cristina Simões e Freitas,Izabella Silva Heilbuth,Thiago Ramos Marco,Luiz Armando de Oliveira,Eduardo Araújo Miranda,Débora Marques |
author_role |
author |
author2 |
Silva,Ana Cristina Simões e Freitas,Izabella Silva Heilbuth,Thiago Ramos Marco,Luiz Armando de Oliveira,Eduardo Araújo Miranda,Débora Marques |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Reis,Geisilaine Soares dos Silva,Ana Cristina Simões e Freitas,Izabella Silva Heilbuth,Thiago Ramos Marco,Luiz Armando de Oliveira,Eduardo Araújo Miranda,Débora Marques |
dc.subject.por.fl_str_mv |
Association study BMP4 Congenital anomalies of the kidney and urinary tract CAKUT |
topic |
Association study BMP4 Congenital anomalies of the kidney and urinary tract CAKUT |
description |
OBJECTIVE: To determine the frequency of different phenotypes for congenital anomalies of the kidney and urinary tract (CAKUT) in a Brazilian sample, and to evaluate the association between the CAKUT phenotypes and the BMP4 gene. METHODS: In this study, 457 Brazilian individuals were analyzed in an attempt to establish the association between the BMP4 gene and the CAKUT diagnosis. A case-control sample was genotyped for three BMP4 gene polymorphisms. RESULTS: Association data was established with CAKUT sample as a whole and with the three most important CAKUT phenotypes: multicystic dysplastic kidney disease (MDK), ureteropelvic junction obstruction (UPJO) and vesicoureteral reflux (VUR). When the sample was segregated in these three phenotypes, associations between the BMP4 gene were observed with UPJO and with MDK. Conversely, VUR was not associated to the polymorphisms of the BMP4 gene. CONCLUSIONS: The present data suggest that Brazilian individuals with polymorphisms of the BMP4 gene have a higher risk to develop CAKUT, especially the malformations related to nephrogenesis and initial branching such as MDK and UPJO. Conversely, VUR appeared not to be related to BMP4 gene. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000100058 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000100058 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2013.06.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.90 n.1 2014 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122319183020032 |