Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,

Detalhes bibliográficos
Autor(a) principal: Jentzsch,Nulma S.
Data de Publicação: 2019
Outros Autores: Silva,Gabriela C.G., Mendes,Guilherme M.S., Brand,Paul L.P., Camargos,Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100069
Resumo: Abstract Objective: There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children. Methods: This was a prospective observational study of 84 patients aged 5–16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000 µg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125 µg)/salmeterol xinafoate (25 µg) combination by metered aerosol/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification. Results: Mean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values ≤ 0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p ≤ 0.001). Conclusion: Adherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control.
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spelling Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,AsthmaFluticasoneSalmeterolInhaled corticosteroidsAbstract Objective: There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children. Methods: This was a prospective observational study of 84 patients aged 5–16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000 µg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125 µg)/salmeterol xinafoate (25 µg) combination by metered aerosol/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification. Results: Mean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values ≤ 0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p ≤ 0.001). Conclusion: Adherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control.Sociedade Brasileira de Pediatria2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100069Jornal de Pediatria v.95 n.1 2019reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2017.10.008info:eu-repo/semantics/openAccessJentzsch,Nulma S.Silva,Gabriela C.G.Mendes,Guilherme M.S.Brand,Paul L.P.Camargos,Pauloeng2019-02-05T00:00:00Zoai:scielo:S0021-75572019000100069Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2019-02-05T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
title Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
spellingShingle Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
Jentzsch,Nulma S.
Asthma
Fluticasone
Salmeterol
Inhaled corticosteroids
title_short Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
title_full Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
title_fullStr Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
title_full_unstemmed Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
title_sort Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol,
author Jentzsch,Nulma S.
author_facet Jentzsch,Nulma S.
Silva,Gabriela C.G.
Mendes,Guilherme M.S.
Brand,Paul L.P.
Camargos,Paulo
author_role author
author2 Silva,Gabriela C.G.
Mendes,Guilherme M.S.
Brand,Paul L.P.
Camargos,Paulo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Jentzsch,Nulma S.
Silva,Gabriela C.G.
Mendes,Guilherme M.S.
Brand,Paul L.P.
Camargos,Paulo
dc.subject.por.fl_str_mv Asthma
Fluticasone
Salmeterol
Inhaled corticosteroids
topic Asthma
Fluticasone
Salmeterol
Inhaled corticosteroids
description Abstract Objective: There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children. Methods: This was a prospective observational study of 84 patients aged 5–16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000 µg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125 µg)/salmeterol xinafoate (25 µg) combination by metered aerosol/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification. Results: Mean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values ≤ 0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p ≤ 0.001). Conclusion: Adherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100069
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2017.10.008
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.95 n.1 2019
reponame:Jornal de Pediatria (Online)
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instname_str Sociedade Brasileira de Pediatria (SBP)
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reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
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