Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups
Main Author: | |
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Publication Date: | 2012 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Journal of the Brazilian Chemical Society (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400021 |
Summary: | Surface engineering for precise positioning of biomolecules is of particular interest for controlled fabrication of biochips. In this study, a novel approach for the preparation of nanodomains with phosphonic diacid groups that were previously shown to reversibly bind to a family of proteins (annexins) in a calcium-dependent manner is described. The strategy makes use of polystyrene-b-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) precursors prepared by atom transfer radical polymerization (ATRP) to obtain hexagonally packed PS cylinders (fPS = 0.25-0.27) in a PHEMA matrix. The pendant hydroxyl groups of PHEMA are then partially (ca. 20%) converted into phosphonic diacid groups via sequential reactions involving phosphorylation, silylation and methanolysis. This process produces PS-b-P(HEMA-co-PEMA) derivatives that still retain the hexagonal morphology, but their degree of structural organization is reduced comparatively to the precursors. |
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Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groupsblock copolymersself-assemblynanostructuresSurface engineering for precise positioning of biomolecules is of particular interest for controlled fabrication of biochips. In this study, a novel approach for the preparation of nanodomains with phosphonic diacid groups that were previously shown to reversibly bind to a family of proteins (annexins) in a calcium-dependent manner is described. The strategy makes use of polystyrene-b-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) precursors prepared by atom transfer radical polymerization (ATRP) to obtain hexagonally packed PS cylinders (fPS = 0.25-0.27) in a PHEMA matrix. The pendant hydroxyl groups of PHEMA are then partially (ca. 20%) converted into phosphonic diacid groups via sequential reactions involving phosphorylation, silylation and methanolysis. This process produces PS-b-P(HEMA-co-PEMA) derivatives that still retain the hexagonal morphology, but their degree of structural organization is reduced comparatively to the precursors.Sociedade Brasileira de Química2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400021Journal of the Brazilian Chemical Society v.23 n.4 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000400021info:eu-repo/semantics/openAccessSchmidt,VanessaBorsali,RedouaneGiacomelli,Cristianoeng2012-04-27T00:00:00Zoai:scielo:S0103-50532012000400021Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-04-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
title |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
spellingShingle |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups Schmidt,Vanessa block copolymers self-assembly nanostructures |
title_short |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
title_full |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
title_fullStr |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
title_full_unstemmed |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
title_sort |
Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups |
author |
Schmidt,Vanessa |
author_facet |
Schmidt,Vanessa Borsali,Redouane Giacomelli,Cristiano |
author_role |
author |
author2 |
Borsali,Redouane Giacomelli,Cristiano |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Schmidt,Vanessa Borsali,Redouane Giacomelli,Cristiano |
dc.subject.por.fl_str_mv |
block copolymers self-assembly nanostructures |
topic |
block copolymers self-assembly nanostructures |
description |
Surface engineering for precise positioning of biomolecules is of particular interest for controlled fabrication of biochips. In this study, a novel approach for the preparation of nanodomains with phosphonic diacid groups that were previously shown to reversibly bind to a family of proteins (annexins) in a calcium-dependent manner is described. The strategy makes use of polystyrene-b-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) precursors prepared by atom transfer radical polymerization (ATRP) to obtain hexagonally packed PS cylinders (fPS = 0.25-0.27) in a PHEMA matrix. The pendant hydroxyl groups of PHEMA are then partially (ca. 20%) converted into phosphonic diacid groups via sequential reactions involving phosphorylation, silylation and methanolysis. This process produces PS-b-P(HEMA-co-PEMA) derivatives that still retain the hexagonal morphology, but their degree of structural organization is reduced comparatively to the precursors. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400021 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000400021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532012000400021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.23 n.4 2012 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318173169647616 |