Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups

Detalhes bibliográficos
Autor(a) principal: Paixão,Márcio W.
Data de Publicação: 2008
Outros Autores: Braga,Antonio L., Lüdtke,Diogo S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500003
Resumo: The transmetalation between boron and zinc is of great importance for application in organic synthesis, since it allows the formation of new carbon-carbon bonds between organometallic units and electrophiles. The direct arylation of aldehydes or more scarcely ketones, in a catalytic, enantioselective manner using chiral catalysts has been described recently. The enantiomerically enriched diarylmethanols obtained in these reactions are valuable precursors for important bioactive molecules. This review provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.
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spelling Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groupsdiarylmethanolboronic acidboron-to-zinc exchangeasymmetric catalysisThe transmetalation between boron and zinc is of great importance for application in organic synthesis, since it allows the formation of new carbon-carbon bonds between organometallic units and electrophiles. The direct arylation of aldehydes or more scarcely ketones, in a catalytic, enantioselective manner using chiral catalysts has been described recently. The enantiomerically enriched diarylmethanols obtained in these reactions are valuable precursors for important bioactive molecules. This review provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500003Journal of the Brazilian Chemical Society v.19 n.5 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000500003info:eu-repo/semantics/openAccessPaixão,Márcio W.Braga,Antonio L.Lüdtke,Diogo S.eng2008-08-05T00:00:00Zoai:scielo:S0103-50532008000500003Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-08-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
title Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
spellingShingle Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
Paixão,Márcio W.
diarylmethanol
boronic acid
boron-to-zinc exchange
asymmetric catalysis
title_short Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
title_full Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
title_fullStr Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
title_full_unstemmed Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
title_sort Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups
author Paixão,Márcio W.
author_facet Paixão,Márcio W.
Braga,Antonio L.
Lüdtke,Diogo S.
author_role author
author2 Braga,Antonio L.
Lüdtke,Diogo S.
author2_role author
author
dc.contributor.author.fl_str_mv Paixão,Márcio W.
Braga,Antonio L.
Lüdtke,Diogo S.
dc.subject.por.fl_str_mv diarylmethanol
boronic acid
boron-to-zinc exchange
asymmetric catalysis
topic diarylmethanol
boronic acid
boron-to-zinc exchange
asymmetric catalysis
description The transmetalation between boron and zinc is of great importance for application in organic synthesis, since it allows the formation of new carbon-carbon bonds between organometallic units and electrophiles. The direct arylation of aldehydes or more scarcely ketones, in a catalytic, enantioselective manner using chiral catalysts has been described recently. The enantiomerically enriched diarylmethanols obtained in these reactions are valuable precursors for important bioactive molecules. This review provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532008000500003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.19 n.5 2008
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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