Genetic toxicity of three symmetrical diselenides in yeast

Detalhes bibliográficos
Autor(a) principal: Rosa,Renato M
Data de Publicação: 2010
Outros Autores: Guecheva,Temenouga N, Oliveira,Iuri M. de, Braga,Antônio L, Henriques,João A. P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100013
Resumo: Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organoselenium (OS) compounds. The aim of the present study was to investigate the mutagenic effects of three symmetrical derivatives from the prototype DPDS (p-chloride-phenyl-diselenide, p-methyl-phenyl-diselenide and p-methoxy-phenyl-diselenide) in yeast. In summary, the cellular effects of the three OS compounds studied in this work appear to be variable according to the substituent group in the aromatic ring and are concentration-dependent. The presence of methoxyl group in the aromatic ring of DPDS structure results in elevation of the cytotoxic and mutagenic potential while the introduction of a methyl group increases the cytotoxic effect.
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spelling Genetic toxicity of three symmetrical diselenides in yeastorganoseleniumdiphenyl diselenideSaccharomyces cerevisiaeDiphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organoselenium (OS) compounds. The aim of the present study was to investigate the mutagenic effects of three symmetrical derivatives from the prototype DPDS (p-chloride-phenyl-diselenide, p-methyl-phenyl-diselenide and p-methoxy-phenyl-diselenide) in yeast. In summary, the cellular effects of the three OS compounds studied in this work appear to be variable according to the substituent group in the aromatic ring and are concentration-dependent. The presence of methoxyl group in the aromatic ring of DPDS structure results in elevation of the cytotoxic and mutagenic potential while the introduction of a methyl group increases the cytotoxic effect.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100013Journal of the Brazilian Chemical Society v.21 n.11 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010001100013info:eu-repo/semantics/openAccessRosa,Renato MGuecheva,Temenouga NOliveira,Iuri M. deBraga,Antônio LHenriques,João A. Peng2010-12-15T00:00:00Zoai:scielo:S0103-50532010001100013Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-12-15T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Genetic toxicity of three symmetrical diselenides in yeast
title Genetic toxicity of three symmetrical diselenides in yeast
spellingShingle Genetic toxicity of three symmetrical diselenides in yeast
Rosa,Renato M
organoselenium
diphenyl diselenide
Saccharomyces cerevisiae
title_short Genetic toxicity of three symmetrical diselenides in yeast
title_full Genetic toxicity of three symmetrical diselenides in yeast
title_fullStr Genetic toxicity of three symmetrical diselenides in yeast
title_full_unstemmed Genetic toxicity of three symmetrical diselenides in yeast
title_sort Genetic toxicity of three symmetrical diselenides in yeast
author Rosa,Renato M
author_facet Rosa,Renato M
Guecheva,Temenouga N
Oliveira,Iuri M. de
Braga,Antônio L
Henriques,João A. P
author_role author
author2 Guecheva,Temenouga N
Oliveira,Iuri M. de
Braga,Antônio L
Henriques,João A. P
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rosa,Renato M
Guecheva,Temenouga N
Oliveira,Iuri M. de
Braga,Antônio L
Henriques,João A. P
dc.subject.por.fl_str_mv organoselenium
diphenyl diselenide
Saccharomyces cerevisiae
topic organoselenium
diphenyl diselenide
Saccharomyces cerevisiae
description Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organoselenium (OS) compounds. The aim of the present study was to investigate the mutagenic effects of three symmetrical derivatives from the prototype DPDS (p-chloride-phenyl-diselenide, p-methyl-phenyl-diselenide and p-methoxy-phenyl-diselenide) in yeast. In summary, the cellular effects of the three OS compounds studied in this work appear to be variable according to the substituent group in the aromatic ring and are concentration-dependent. The presence of methoxyl group in the aromatic ring of DPDS structure results in elevation of the cytotoxic and mutagenic potential while the introduction of a methyl group increases the cytotoxic effect.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010001100013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010001100013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.11 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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