Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Detalhes bibliográficos
Autor(a) principal: Charles-Navarro,Dalia
Data de Publicação: 2010
Outros Autores: Bocanegra-García,Virgilio, Palos,Isidro, Rivera,Gildardo, Esquivel-Ferriño,Patricia, Gracia-Vásquez,Sandra, Ortiz-Andrade,Rolffy, Quiroz-Velásquez,Jesús, Hernández-Mendoza,José Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002
Resumo: The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q &gt; 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.
id SBQ-3_5132e1d6074566cda883bb05f52cc7dc
oai_identifier_str oai:scielo:S0100-40422010000700002
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beadsglibenclamidecalcium-alginate beadsdissolutionThe aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q &gt; 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002Química Nova v.33 n.7 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000700002info:eu-repo/semantics/openAccessCharles-Navarro,DaliaBocanegra-García,VirgilioPalos,IsidroRivera,GildardoEsquivel-Ferriño,PatriciaGracia-Vásquez,SandraOrtiz-Andrade,RolffyQuiroz-Velásquez,JesúsHernández-Mendoza,José Luiseng2010-09-27T00:00:00Zoai:scielo:S0100-40422010000700002Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-09-27T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
title Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
spellingShingle Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
Charles-Navarro,Dalia
glibenclamide
calcium-alginate beads
dissolution
title_short Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
title_full Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
title_fullStr Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
title_full_unstemmed Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
title_sort Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
author Charles-Navarro,Dalia
author_facet Charles-Navarro,Dalia
Bocanegra-García,Virgilio
Palos,Isidro
Rivera,Gildardo
Esquivel-Ferriño,Patricia
Gracia-Vásquez,Sandra
Ortiz-Andrade,Rolffy
Quiroz-Velásquez,Jesús
Hernández-Mendoza,José Luis
author_role author
author2 Bocanegra-García,Virgilio
Palos,Isidro
Rivera,Gildardo
Esquivel-Ferriño,Patricia
Gracia-Vásquez,Sandra
Ortiz-Andrade,Rolffy
Quiroz-Velásquez,Jesús
Hernández-Mendoza,José Luis
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Charles-Navarro,Dalia
Bocanegra-García,Virgilio
Palos,Isidro
Rivera,Gildardo
Esquivel-Ferriño,Patricia
Gracia-Vásquez,Sandra
Ortiz-Andrade,Rolffy
Quiroz-Velásquez,Jesús
Hernández-Mendoza,José Luis
dc.subject.por.fl_str_mv glibenclamide
calcium-alginate beads
dissolution
topic glibenclamide
calcium-alginate beads
dissolution
description The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q &gt; 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000700002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.7 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318111076122624