Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500028 |
Resumo: | A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods. |
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Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage formsrupatadinedissolution testRP-LCA dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500028Química Nova v.33 n.5 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000500028info:eu-repo/semantics/openAccessDalmora,Sérgio LuizNogueira,Daniele RubertCalegari,Guilherme ZaniniBergamo,Ana CláudiaStamm,Fernanda Pavanieng2010-07-23T00:00:00Zoai:scielo:S0100-40422010000500028Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-07-23T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
title |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
spellingShingle |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms Dalmora,Sérgio Luiz rupatadine dissolution test RP-LC |
title_short |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
title_full |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
title_fullStr |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
title_full_unstemmed |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
title_sort |
Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms |
author |
Dalmora,Sérgio Luiz |
author_facet |
Dalmora,Sérgio Luiz Nogueira,Daniele Rubert Calegari,Guilherme Zanini Bergamo,Ana Cláudia Stamm,Fernanda Pavani |
author_role |
author |
author2 |
Nogueira,Daniele Rubert Calegari,Guilherme Zanini Bergamo,Ana Cláudia Stamm,Fernanda Pavani |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Dalmora,Sérgio Luiz Nogueira,Daniele Rubert Calegari,Guilherme Zanini Bergamo,Ana Cláudia Stamm,Fernanda Pavani |
dc.subject.por.fl_str_mv |
rupatadine dissolution test RP-LC |
topic |
rupatadine dissolution test RP-LC |
description |
A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500028 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000500028 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422010000500028 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.33 n.5 2010 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318110745821184 |