NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206 |
Resumo: | Silver nanoparticles (AgNPs) have important antimicrobial activity. These nanoparticles are present in several commercial products, leading to human and environmental exposure. This review presents a critical view of the toxic effects of Ag NPs on in vitro and in vivo biological models. It is noteworthy that the toxicity of AgNPs is dependent on several parameters, such as the preparation mode of the colloidal suspension of the nanoparticles, their state of aggregation, the chemical nature of the nanoparticles, surface size, morphology, dose, cell type, nature of the living organism, among others. In general, low concentrations of AgNPs do not present significant toxicity in in vitro and in vivo assays, however with the increase of the concentration of AgNPs there is a significant increase of nanoparticle toxicity and its accumulation in diverse tissues/organs. It should be emphasized that in living organisms, exposure routes should be taken into account, such as ingestion and inhalation. At high concentrations, inhalation or ingestion of AgNPs can cause adverse effects and even lead to human death. In this context, the importance of further studies of the toxicity of AgNPs in several in vitro and in vivo models is emphasized. |
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NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOSsilver nanoparticlesnanotoxicityin vitro toxicityin vivo toxicitySilver nanoparticles (AgNPs) have important antimicrobial activity. These nanoparticles are present in several commercial products, leading to human and environmental exposure. This review presents a critical view of the toxic effects of Ag NPs on in vitro and in vivo biological models. It is noteworthy that the toxicity of AgNPs is dependent on several parameters, such as the preparation mode of the colloidal suspension of the nanoparticles, their state of aggregation, the chemical nature of the nanoparticles, surface size, morphology, dose, cell type, nature of the living organism, among others. In general, low concentrations of AgNPs do not present significant toxicity in in vitro and in vivo assays, however with the increase of the concentration of AgNPs there is a significant increase of nanoparticle toxicity and its accumulation in diverse tissues/organs. It should be emphasized that in living organisms, exposure routes should be taken into account, such as ingestion and inhalation. At high concentrations, inhalation or ingestion of AgNPs can cause adverse effects and even lead to human death. In this context, the importance of further studies of the toxicity of AgNPs in several in vitro and in vivo models is emphasized.Sociedade Brasileira de Química2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206Química Nova v.42 n.2 2019reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170318info:eu-repo/semantics/openAccessDurán,NelsonRolim,Wallace R.Durán,MarcelaFávaro,Wagner J.Seabra,Amedea B.por2019-03-25T00:00:00Zoai:scielo:S0100-40422019000200206Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2019-03-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
title |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
spellingShingle |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS Durán,Nelson silver nanoparticles nanotoxicity in vitro toxicity in vivo toxicity |
title_short |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
title_full |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
title_fullStr |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
title_full_unstemmed |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
title_sort |
NANOTOXICOLOGIA DE NANOPARTÍCULAS DE PRATA: TOXICIDADE EM ANIMAIS E HUMANOS |
author |
Durán,Nelson |
author_facet |
Durán,Nelson Rolim,Wallace R. Durán,Marcela Fávaro,Wagner J. Seabra,Amedea B. |
author_role |
author |
author2 |
Rolim,Wallace R. Durán,Marcela Fávaro,Wagner J. Seabra,Amedea B. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Durán,Nelson Rolim,Wallace R. Durán,Marcela Fávaro,Wagner J. Seabra,Amedea B. |
dc.subject.por.fl_str_mv |
silver nanoparticles nanotoxicity in vitro toxicity in vivo toxicity |
topic |
silver nanoparticles nanotoxicity in vitro toxicity in vivo toxicity |
description |
Silver nanoparticles (AgNPs) have important antimicrobial activity. These nanoparticles are present in several commercial products, leading to human and environmental exposure. This review presents a critical view of the toxic effects of Ag NPs on in vitro and in vivo biological models. It is noteworthy that the toxicity of AgNPs is dependent on several parameters, such as the preparation mode of the colloidal suspension of the nanoparticles, their state of aggregation, the chemical nature of the nanoparticles, surface size, morphology, dose, cell type, nature of the living organism, among others. In general, low concentrations of AgNPs do not present significant toxicity in in vitro and in vivo assays, however with the increase of the concentration of AgNPs there is a significant increase of nanoparticle toxicity and its accumulation in diverse tissues/organs. It should be emphasized that in living organisms, exposure routes should be taken into account, such as ingestion and inhalation. At high concentrations, inhalation or ingestion of AgNPs can cause adverse effects and even lead to human death. In this context, the importance of further studies of the toxicity of AgNPs in several in vitro and in vivo models is emphasized. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000200206 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.42 n.2 2019 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318119607336960 |