Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul

Detalhes bibliográficos
Autor(a) principal: Mallmann Júnior, Pedro Marino
Data de Publicação: 2018
Outros Autores: Raimondo, Raquel Fraga e Silva, Rivero, Beatriz Riet Correa, Jacondino, Luiza Rodegheri, Gonçalves, Andressa Silveira, Silveira, Brenda Oliveira, Oberst, Eneder Rosana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/31702
Resumo: The excessive, indiscriminate, and continued use of anthelmintic drugs as control methods favors parasite resistance, and this phenomenon has been reported in Brazil and worldwide. The current status of parasite resistance to anthelmintic drugs in sheep flocks in Rio Grande do Sul was assessed by calculating the EPG count in the stool to estimate the prevalence of resistance to the anthelmintic drugs closantel, levamisole, fenbendazole, monepantel, and moxidectin in seven properties. The animals from each flock were randomly distributed in six groups according to the anthelminthic drug used, as follows: T1, levamisole; T2, fenbendazole; T3, monepantel; T4, moxidectin; T5, closantel; and T6, control. On day zero, fecal samples were collected, and each animal was treated with one anthelminthic drug. Fecal samples were collected again after 14 days to calculate the efficacy of each active principle. Coproculture was performed using a pool of fecal samples from each group on day 0 and 14 to identify the predominant genera and prevalence of helminths. The genera identified in the coprocultures were Haemonchus, Trichostrongylus, Oesophagostomum, and Teladorsagia. All flocks developed resistance to levamisole, fenbendazole, moxidectin, and closantel. Moreover, resistance to monepantel was found in four of the seven farms. These results demonstrate the critical situation of anthelmintic resistance in sheep flocks in Rio Grande do Sul and the need to adopt other integrated control measures in addition to anthelmintic treatment.
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spelling Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do SulResistência ao Monepantel em nematoides gastrintestinais multiresistentes em rebanhos ovinos no Rio Grande do SulGastrointestinal nematodesParasitic resistanceMonepantelHaemonchus contortusOPGSheep.Nematoides gastrintestinaisResistência parasitáriaMonepantelHaemonchus contortusOPGOvinos.The excessive, indiscriminate, and continued use of anthelmintic drugs as control methods favors parasite resistance, and this phenomenon has been reported in Brazil and worldwide. The current status of parasite resistance to anthelmintic drugs in sheep flocks in Rio Grande do Sul was assessed by calculating the EPG count in the stool to estimate the prevalence of resistance to the anthelmintic drugs closantel, levamisole, fenbendazole, monepantel, and moxidectin in seven properties. The animals from each flock were randomly distributed in six groups according to the anthelminthic drug used, as follows: T1, levamisole; T2, fenbendazole; T3, monepantel; T4, moxidectin; T5, closantel; and T6, control. On day zero, fecal samples were collected, and each animal was treated with one anthelminthic drug. Fecal samples were collected again after 14 days to calculate the efficacy of each active principle. Coproculture was performed using a pool of fecal samples from each group on day 0 and 14 to identify the predominant genera and prevalence of helminths. The genera identified in the coprocultures were Haemonchus, Trichostrongylus, Oesophagostomum, and Teladorsagia. All flocks developed resistance to levamisole, fenbendazole, moxidectin, and closantel. Moreover, resistance to monepantel was found in four of the seven farms. These results demonstrate the critical situation of anthelmintic resistance in sheep flocks in Rio Grande do Sul and the need to adopt other integrated control measures in addition to anthelmintic treatment.Uso excessivo, indiscriminado e continuado de anti-helmínticos como métodos de controle favorece o desenvolvimento de isolados de parasitos resistentes, fenômeno relatado no Brasil e no mundo. Com o objetivo de verificar a atual situação da resistência anti-helmíntica em rebanhos ovinos no Rio Grande do Sul, foram realizados testes de redução da contagem de OPG nas fezes (TRCOF), a fim de estimar a prevalência de resistência parasitária em sete propriedades utilizando os seguintes anti-helmínticos: closantel, levamisol, fenbendazol, monepantel e moxidectina. Em cada rebanho os animais foram distribuídos aleatoriamente, respeitando a homogeneidade de categorias, em seis grupos, T1 - levamisol, T2 - fenbendazol, T3 - monepantel, T4 - moxidectina, T5 - closantel e T6 - controle. No dia zero foram coletadas amostras de fezes e os animais foram tratados, após 14 dias foi feita nova coleta de fezes para calcular a eficácia de cada princípio ativo. A coprocultura foi realizada através de um pool de fezes de cada grupo no dia 0 e 14 para identificação dos principais gêneros e as suas prevalências. Os gêneros de helmintos identificados nas coproculturas realizadas foram: Haemonchus, Trichostrongylus, Oesophagostomum e Teladorsagia. Em todos os rebanhos foi diagnosticada resistência ao levamisol, febendazol, moxidectina e closantel, e, em quatro das sete propriedades foi encontrada resistência ao monepantel. Alerta-se para a situação crítica da resistência anti-helmíntica nos rebanhos gaúchos e a necessidade de se adotarem outras medidas de controle integrado além do tratamento exclusivo com anti-helmíntico.UEL2018-08-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/3170210.5433/1679-0359.2018v39n5p2059Semina: Ciências Agrárias; Vol. 39 No. 5 (2018); 2059-2070Semina: Ciências Agrárias; v. 39 n. 5 (2018); 2059-20701679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/31702/24251Copyright (c) 2018 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessMallmann Júnior, Pedro MarinoRaimondo, Raquel Fraga e SilvaRivero, Beatriz Riet CorreaJacondino, Luiza RodegheriGonçalves, Andressa SilveiraSilveira, Brenda OliveiraOberst, Eneder Rosana2022-10-20T18:00:46Zoai:ojs.pkp.sfu.ca:article/31702Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-20T18:00:46Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
Resistência ao Monepantel em nematoides gastrintestinais multiresistentes em rebanhos ovinos no Rio Grande do Sul
title Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
spellingShingle Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
Mallmann Júnior, Pedro Marino
Gastrointestinal nematodes
Parasitic resistance
Monepantel
Haemonchus contortus
OPG
Sheep.
Nematoides gastrintestinais
Resistência parasitária
Monepantel
Haemonchus contortus
OPG
Ovinos.
title_short Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
title_full Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
title_fullStr Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
title_full_unstemmed Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
title_sort Resistance to monepantel in multiresistant gastrointestinal nematodes in sheep flocks in Rio Grande do Sul
author Mallmann Júnior, Pedro Marino
author_facet Mallmann Júnior, Pedro Marino
Raimondo, Raquel Fraga e Silva
Rivero, Beatriz Riet Correa
Jacondino, Luiza Rodegheri
Gonçalves, Andressa Silveira
Silveira, Brenda Oliveira
Oberst, Eneder Rosana
author_role author
author2 Raimondo, Raquel Fraga e Silva
Rivero, Beatriz Riet Correa
Jacondino, Luiza Rodegheri
Gonçalves, Andressa Silveira
Silveira, Brenda Oliveira
Oberst, Eneder Rosana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mallmann Júnior, Pedro Marino
Raimondo, Raquel Fraga e Silva
Rivero, Beatriz Riet Correa
Jacondino, Luiza Rodegheri
Gonçalves, Andressa Silveira
Silveira, Brenda Oliveira
Oberst, Eneder Rosana
dc.subject.por.fl_str_mv Gastrointestinal nematodes
Parasitic resistance
Monepantel
Haemonchus contortus
OPG
Sheep.
Nematoides gastrintestinais
Resistência parasitária
Monepantel
Haemonchus contortus
OPG
Ovinos.
topic Gastrointestinal nematodes
Parasitic resistance
Monepantel
Haemonchus contortus
OPG
Sheep.
Nematoides gastrintestinais
Resistência parasitária
Monepantel
Haemonchus contortus
OPG
Ovinos.
description The excessive, indiscriminate, and continued use of anthelmintic drugs as control methods favors parasite resistance, and this phenomenon has been reported in Brazil and worldwide. The current status of parasite resistance to anthelmintic drugs in sheep flocks in Rio Grande do Sul was assessed by calculating the EPG count in the stool to estimate the prevalence of resistance to the anthelmintic drugs closantel, levamisole, fenbendazole, monepantel, and moxidectin in seven properties. The animals from each flock were randomly distributed in six groups according to the anthelminthic drug used, as follows: T1, levamisole; T2, fenbendazole; T3, monepantel; T4, moxidectin; T5, closantel; and T6, control. On day zero, fecal samples were collected, and each animal was treated with one anthelminthic drug. Fecal samples were collected again after 14 days to calculate the efficacy of each active principle. Coproculture was performed using a pool of fecal samples from each group on day 0 and 14 to identify the predominant genera and prevalence of helminths. The genera identified in the coprocultures were Haemonchus, Trichostrongylus, Oesophagostomum, and Teladorsagia. All flocks developed resistance to levamisole, fenbendazole, moxidectin, and closantel. Moreover, resistance to monepantel was found in four of the seven farms. These results demonstrate the critical situation of anthelmintic resistance in sheep flocks in Rio Grande do Sul and the need to adopt other integrated control measures in addition to anthelmintic treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/31702
10.5433/1679-0359.2018v39n5p2059
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/31702
identifier_str_mv 10.5433/1679-0359.2018v39n5p2059
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/31702/24251
dc.rights.driver.fl_str_mv Copyright (c) 2018 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 39 No. 5 (2018); 2059-2070
Semina: Ciências Agrárias; v. 39 n. 5 (2018); 2059-2070
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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