Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep

Detalhes bibliográficos
Autor(a) principal: DeRossi,Rafael
Data de Publicação: 2012
Outros Autores: Pompermeyer,Cassio Tadeu Dias, Silva-Neto,Amadeu Batista, Barros,Andrea Lantieri Correa de, Jardim,Paulo Henrique de Affonseca, Frazílio,Fabrício Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200007
Resumo: PURPOSE: To determine the analgesic, motor, sedation and systemic effects of lumbosacral epidural magnesium sulphate added to ketamine in the sheep. METHODS: Six healthy adult male mixed-breed sheep; weighing 43 ± 5 kg and aged 20-36 months. Each sheep underwent three treatments, at least 2 weeks apart, via epidural injection: (1) ketamine (KE; 2.5 mg/kg), (2) magnesium sulphate (MG; 100 mg), and (3) KE + MG (KEMG; 2.5 mg/kg + 100 mg, respectively). Epidural injections were administered through the lumbosacral space. Analgesia, motor block, sedation, cardiovascular effects, respiratory rate, skin temperature, and rectal temperature were evaluated before (baseline) and after drug administration as needed. RESULTS: The duration of analgesia with the lumbosacral epidural KEMG combination was 115 ± 17 min (mean ± SD), that is, more than twice that obtained with KE (41 ± 7 min) or MG (29 ± 5 min) alone. KE and KEMG used in this experiment induced severe ataxia. The heart rate and arterial blood pressures changes were no statistical difference in these clinically health sheep. CONCLUSION: The dose of magnesium sulphate to lumbosacral epidural ketamine in sheep is feasible, and can be used in procedures analgesics in sheep.
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spelling Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheepKetamineAnalgesia, EpiduralMagnesium SulfateSheepPURPOSE: To determine the analgesic, motor, sedation and systemic effects of lumbosacral epidural magnesium sulphate added to ketamine in the sheep. METHODS: Six healthy adult male mixed-breed sheep; weighing 43 ± 5 kg and aged 20-36 months. Each sheep underwent three treatments, at least 2 weeks apart, via epidural injection: (1) ketamine (KE; 2.5 mg/kg), (2) magnesium sulphate (MG; 100 mg), and (3) KE + MG (KEMG; 2.5 mg/kg + 100 mg, respectively). Epidural injections were administered through the lumbosacral space. Analgesia, motor block, sedation, cardiovascular effects, respiratory rate, skin temperature, and rectal temperature were evaluated before (baseline) and after drug administration as needed. RESULTS: The duration of analgesia with the lumbosacral epidural KEMG combination was 115 ± 17 min (mean ± SD), that is, more than twice that obtained with KE (41 ± 7 min) or MG (29 ± 5 min) alone. KE and KEMG used in this experiment induced severe ataxia. The heart rate and arterial blood pressures changes were no statistical difference in these clinically health sheep. CONCLUSION: The dose of magnesium sulphate to lumbosacral epidural ketamine in sheep is feasible, and can be used in procedures analgesics in sheep.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200007Acta Cirúrgica Brasileira v.27 n.2 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012000200007info:eu-repo/semantics/openAccessDeRossi,RafaelPompermeyer,Cassio Tadeu DiasSilva-Neto,Amadeu BatistaBarros,Andrea Lantieri Correa deJardim,Paulo Henrique de AffonsecaFrazílio,Fabrício Oliveiraeng2012-02-27T00:00:00Zoai:scielo:S0102-86502012000200007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-02-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
title Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
spellingShingle Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
DeRossi,Rafael
Ketamine
Analgesia, Epidural
Magnesium Sulfate
Sheep
title_short Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
title_full Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
title_fullStr Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
title_full_unstemmed Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
title_sort Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep
author DeRossi,Rafael
author_facet DeRossi,Rafael
Pompermeyer,Cassio Tadeu Dias
Silva-Neto,Amadeu Batista
Barros,Andrea Lantieri Correa de
Jardim,Paulo Henrique de Affonseca
Frazílio,Fabrício Oliveira
author_role author
author2 Pompermeyer,Cassio Tadeu Dias
Silva-Neto,Amadeu Batista
Barros,Andrea Lantieri Correa de
Jardim,Paulo Henrique de Affonseca
Frazílio,Fabrício Oliveira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv DeRossi,Rafael
Pompermeyer,Cassio Tadeu Dias
Silva-Neto,Amadeu Batista
Barros,Andrea Lantieri Correa de
Jardim,Paulo Henrique de Affonseca
Frazílio,Fabrício Oliveira
dc.subject.por.fl_str_mv Ketamine
Analgesia, Epidural
Magnesium Sulfate
Sheep
topic Ketamine
Analgesia, Epidural
Magnesium Sulfate
Sheep
description PURPOSE: To determine the analgesic, motor, sedation and systemic effects of lumbosacral epidural magnesium sulphate added to ketamine in the sheep. METHODS: Six healthy adult male mixed-breed sheep; weighing 43 ± 5 kg and aged 20-36 months. Each sheep underwent three treatments, at least 2 weeks apart, via epidural injection: (1) ketamine (KE; 2.5 mg/kg), (2) magnesium sulphate (MG; 100 mg), and (3) KE + MG (KEMG; 2.5 mg/kg + 100 mg, respectively). Epidural injections were administered through the lumbosacral space. Analgesia, motor block, sedation, cardiovascular effects, respiratory rate, skin temperature, and rectal temperature were evaluated before (baseline) and after drug administration as needed. RESULTS: The duration of analgesia with the lumbosacral epidural KEMG combination was 115 ± 17 min (mean ± SD), that is, more than twice that obtained with KE (41 ± 7 min) or MG (29 ± 5 min) alone. KE and KEMG used in this experiment induced severe ataxia. The heart rate and arterial blood pressures changes were no statistical difference in these clinically health sheep. CONCLUSION: The dose of magnesium sulphate to lumbosacral epidural ketamine in sheep is feasible, and can be used in procedures analgesics in sheep.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502012000200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.27 n.2 2012
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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