Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.

Detalhes bibliográficos
Autor(a) principal: Ferreira, Jaqueline Maria Siqueira
Data de Publicação: 2008
Outros Autores: Drumond, Betânia Paiva, Guedes, Maria Isabel Maldonado Coelho, Xavier, Marcelo Antônio Pascoal, Leite, Camila Megale Almeida, Arantes, Rosa Maria Esteves, Mota, Bruno Eduardo Fernandes, Abrahão, Jônatas Santos, Alves, Pedro Augusto, Oliveira, Fernando Meireles, Ferreira, Paulo César Peregrino, Bonjardim, Cláudio Antônio, Lobato, Zélia Inês Portela, Kroon, Erna Geessien
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/4177
https://doi.org/10.1371/journal.pone.0003043
Resumo: Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological characteristics. Therefore, our goal was to study the virulence pattern of seven Brazilian Vaccinia virus strains. Infected BALB/c mice were monitored for morbidity, mortality and viral replication in organs as trachea, lungs, heart, kidneys, liver, brain and spleen. Based on the virulence potential, the Brazilian Vaccinia virus strains were grouped into two groups. One group contained GP1V, VBH, SAV and BAV which caused disease and death in infected mice and the second one included ARAV, GP2V and PSTV which did not cause any clinical signals or death in infected BALB/ c mice. The subdivision of Brazilian Vaccinia virus strains into two groups is in agreement with previous genetic studies. Those data reinforce the existence of different populations circulating in Brazil regarding the genetic and virulence characteristics.
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spelling Ferreira, Jaqueline Maria SiqueiraDrumond, Betânia PaivaGuedes, Maria Isabel Maldonado CoelhoXavier, Marcelo Antônio PascoalLeite, Camila Megale AlmeidaArantes, Rosa Maria EstevesMota, Bruno Eduardo FernandesAbrahão, Jônatas SantosAlves, Pedro AugustoOliveira, Fernando MeirelesFerreira, Paulo César PeregrinoBonjardim, Cláudio AntônioLobato, Zélia Inês PortelaKroon, Erna Geessien2014-12-16T23:25:40Z2014-12-16T23:25:40Z2008FERREIRA, J. M. S. et al. Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains. Plos One, v. 3, p. e3043-e3043, 2008. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003043>. Acesso em: 08 nov. 2014.1932-6203http://www.repositorio.ufop.br/handle/123456789/4177https://doi.org/10.1371/journal.pone.0003043Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological characteristics. Therefore, our goal was to study the virulence pattern of seven Brazilian Vaccinia virus strains. Infected BALB/c mice were monitored for morbidity, mortality and viral replication in organs as trachea, lungs, heart, kidneys, liver, brain and spleen. Based on the virulence potential, the Brazilian Vaccinia virus strains were grouped into two groups. One group contained GP1V, VBH, SAV and BAV which caused disease and death in infected mice and the second one included ARAV, GP2V and PSTV which did not cause any clinical signals or death in infected BALB/ c mice. The subdivision of Brazilian Vaccinia virus strains into two groups is in agreement with previous genetic studies. Those data reinforce the existence of different populations circulating in Brazil regarding the genetic and virulence characteristics.Vaccinia virusSmallpoxVaríolaVirulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNenhuma autorização é necessária para depósito dos artigos publicados pelos Periódicos PloS em repositório. Fonte: Plos <http://www.plos.org/open-access/> Acesso em: 14 nov. 2014.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-82636http://www.repositorio.ufop.br/bitstream/123456789/4177/2/license.txtc2ffdd99e58acf69202dff00d361f23aMD52ORIGINALARTIGO_VirulenceMurineModel.pdfARTIGO_VirulenceMurineModel.pdfapplication/pdf538314http://www.repositorio.ufop.br/bitstream/123456789/4177/1/ARTIGO_VirulenceMurineModel.pdf85c579eef043fe6a1049b15f64e65b76MD51123456789/41772019-09-16 13:28:04.082oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-09-16T17:28:04Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
title Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
spellingShingle Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
Ferreira, Jaqueline Maria Siqueira
Vaccinia virus
Smallpox
Varíola
title_short Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
title_full Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
title_fullStr Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
title_full_unstemmed Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
title_sort Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains.
author Ferreira, Jaqueline Maria Siqueira
author_facet Ferreira, Jaqueline Maria Siqueira
Drumond, Betânia Paiva
Guedes, Maria Isabel Maldonado Coelho
Xavier, Marcelo Antônio Pascoal
Leite, Camila Megale Almeida
Arantes, Rosa Maria Esteves
Mota, Bruno Eduardo Fernandes
Abrahão, Jônatas Santos
Alves, Pedro Augusto
Oliveira, Fernando Meireles
Ferreira, Paulo César Peregrino
Bonjardim, Cláudio Antônio
Lobato, Zélia Inês Portela
Kroon, Erna Geessien
author_role author
author2 Drumond, Betânia Paiva
Guedes, Maria Isabel Maldonado Coelho
Xavier, Marcelo Antônio Pascoal
Leite, Camila Megale Almeida
Arantes, Rosa Maria Esteves
Mota, Bruno Eduardo Fernandes
Abrahão, Jônatas Santos
Alves, Pedro Augusto
Oliveira, Fernando Meireles
Ferreira, Paulo César Peregrino
Bonjardim, Cláudio Antônio
Lobato, Zélia Inês Portela
Kroon, Erna Geessien
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Jaqueline Maria Siqueira
Drumond, Betânia Paiva
Guedes, Maria Isabel Maldonado Coelho
Xavier, Marcelo Antônio Pascoal
Leite, Camila Megale Almeida
Arantes, Rosa Maria Esteves
Mota, Bruno Eduardo Fernandes
Abrahão, Jônatas Santos
Alves, Pedro Augusto
Oliveira, Fernando Meireles
Ferreira, Paulo César Peregrino
Bonjardim, Cláudio Antônio
Lobato, Zélia Inês Portela
Kroon, Erna Geessien
dc.subject.por.fl_str_mv Vaccinia virus
Smallpox
Varíola
topic Vaccinia virus
Smallpox
Varíola
description Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological characteristics. Therefore, our goal was to study the virulence pattern of seven Brazilian Vaccinia virus strains. Infected BALB/c mice were monitored for morbidity, mortality and viral replication in organs as trachea, lungs, heart, kidneys, liver, brain and spleen. Based on the virulence potential, the Brazilian Vaccinia virus strains were grouped into two groups. One group contained GP1V, VBH, SAV and BAV which caused disease and death in infected mice and the second one included ARAV, GP2V and PSTV which did not cause any clinical signals or death in infected BALB/ c mice. The subdivision of Brazilian Vaccinia virus strains into two groups is in agreement with previous genetic studies. Those data reinforce the existence of different populations circulating in Brazil regarding the genetic and virulence characteristics.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-12-16T23:25:40Z
dc.date.available.fl_str_mv 2014-12-16T23:25:40Z
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dc.identifier.citation.fl_str_mv FERREIRA, J. M. S. et al. Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains. Plos One, v. 3, p. e3043-e3043, 2008. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003043>. Acesso em: 08 nov. 2014.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/4177
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1371/journal.pone.0003043
identifier_str_mv FERREIRA, J. M. S. et al. Virulence in murine model shows the existence of two distinct populations of Brazilian vaccinia virus strains. Plos One, v. 3, p. e3043-e3043, 2008. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003043>. Acesso em: 08 nov. 2014.
1932-6203
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https://doi.org/10.1371/journal.pone.0003043
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