Corticosteroids for severe influenza pneumonia : a critical appraisal
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Publication Date: | 2016 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRGS |
Download full: | http://hdl.handle.net/10183/165420 |
Summary: | Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit (ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in severe influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials. |
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Nedel, Wagner LuísNora, David José GarciaSalluh, Jorge Ibrain FigueiraLisboa, Thiago CostaPóvoa, Pedro2017-08-16T02:38:44Z20162220-3141http://hdl.handle.net/10183/165420001027368Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit (ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in severe influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials.application/pdfengWorld Journal of Critical Care Medicine. Pleasanton, CA. Vol. 5, no. 1 (Feb. 2016), p. 89-95.CorticosteróidesInsuficiência respiratóriaInfluenza humanaRespiração artificialPneumoniaInfluenzaMechanical ventilationPneumoniaCorticosteroidsRespiratory failureCorticosteroids for severe influenza pneumonia : a critical appraisalEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001027368.pdf001027368.pdfTexto completo (inglês)application/pdf952934http://www.lume.ufrgs.br/bitstream/10183/165420/1/001027368.pdf449a199c7b81facb63f989763a169159MD51TEXT001027368.pdf.txt001027368.pdf.txtExtracted Texttext/plain38502http://www.lume.ufrgs.br/bitstream/10183/165420/2/001027368.pdf.txt32298f8a255a0c10d833cb2c4e6dc7b8MD52THUMBNAIL001027368.pdf.jpg001027368.pdf.jpgGenerated Thumbnailimage/jpeg2531http://www.lume.ufrgs.br/bitstream/10183/165420/3/001027368.pdf.jpg0c84ebf20dbe1430b046fbcab2bda43fMD5310183/1654202023-05-20 03:56:52.880582oai:www.lume.ufrgs.br:10183/165420Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-20T06:56:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
title |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
spellingShingle |
Corticosteroids for severe influenza pneumonia : a critical appraisal Nedel, Wagner Luís Corticosteróides Insuficiência respiratória Influenza humana Respiração artificial Pneumonia Influenza Mechanical ventilation Pneumonia Corticosteroids Respiratory failure |
title_short |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
title_full |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
title_fullStr |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
title_full_unstemmed |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
title_sort |
Corticosteroids for severe influenza pneumonia : a critical appraisal |
author |
Nedel, Wagner Luís |
author_facet |
Nedel, Wagner Luís Nora, David José Garcia Salluh, Jorge Ibrain Figueira Lisboa, Thiago Costa Póvoa, Pedro |
author_role |
author |
author2 |
Nora, David José Garcia Salluh, Jorge Ibrain Figueira Lisboa, Thiago Costa Póvoa, Pedro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nedel, Wagner Luís Nora, David José Garcia Salluh, Jorge Ibrain Figueira Lisboa, Thiago Costa Póvoa, Pedro |
dc.subject.por.fl_str_mv |
Corticosteróides Insuficiência respiratória Influenza humana Respiração artificial Pneumonia |
topic |
Corticosteróides Insuficiência respiratória Influenza humana Respiração artificial Pneumonia Influenza Mechanical ventilation Pneumonia Corticosteroids Respiratory failure |
dc.subject.eng.fl_str_mv |
Influenza Mechanical ventilation Pneumonia Corticosteroids Respiratory failure |
description |
Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit (ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in severe influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-08-16T02:38:44Z |
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Estrangeiro info:eu-repo/semantics/article |
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001027368 |
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World Journal of Critical Care Medicine. Pleasanton, CA. Vol. 5, no. 1 (Feb. 2016), p. 89-95. |
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