Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio

Detalhes bibliográficos
Autor(a) principal: Santos, Andr? Marandola dos
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/3099
Resumo: Sodium monofluoroacetate (MF) is the toxic principle of several plants that cause ?sudden death? of cattle in Brazil. Groups of cardiomyocites with high cytoplasmic eosinophilia are sometimes observed in animals poisoned by MF. However, this cardiac alteration is difficult to interpret and as there is no inflammatory reaction, it must be differentiated from artifacts. The present study had the objective to detect the presence of early regressive lesions in the myocardium of sheep and cattle experimentally poisoned by MF through immunohistochemistry with troponin C (cTnC). Fragments of the heart muscle from six cattle (three received, orally, single doses of 0.5 mg/kg and the others, single doses of 1.0 mg/kg) and five sheep (one received, orally, single dose of 0.5 mg/kg, the other two received single doses of 1.0 mg/kg, one received sublethal daily doses of 0.1 mg/kg for four days, and another received daily sublethal doses of 0.2 mg/kg for six days) were submitted to immunohistochemistry with antibody anti-cTnC. In the cardiomyocites of cattle and sheep, it was possible to observe reduction of the expression levels for cTnC in the cytoplasm of groups of cardiac muscle fibers. Significant reduction of immunoreactivity ocurred overall in cardiomyocites that presented high cytoplasmic eosinophilia. The decrease or absence of expression. for cTnC in animals poisoned by MF allowed to estabilish the difference between coagulative necrosis of cardiomyocites and artifacts caused by fixation. This indicates that this method can be used safely to identify any lesions, early regressive or not, in the myocardium independently of the cause. It is also possible to affirm that poisoning by MF as well as the one caused by ?sudden death? causing plants can progress with regressive myocardial lesions
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spelling Nogueira, Vivian de Assun??o089.375.877-93http://lattes.cnpq.br/6012855368365110Peixoto, Paulo Vargas270.761.210-34http://lattes.cnpq.br/3002512195318611Caldas, Saulo AndradeD?bereiner, J?rgen136.187.587-90http://lattes.cnpq.br/1341170071765519Santos, Andr? Marandola dos2019-11-21T12:27:49Z2015-02-25SANTOS, Andr? Marandola dos. Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio. 2015. 59 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.https://tede.ufrrj.br/jspui/handle/jspui/3099Sodium monofluoroacetate (MF) is the toxic principle of several plants that cause ?sudden death? of cattle in Brazil. Groups of cardiomyocites with high cytoplasmic eosinophilia are sometimes observed in animals poisoned by MF. However, this cardiac alteration is difficult to interpret and as there is no inflammatory reaction, it must be differentiated from artifacts. The present study had the objective to detect the presence of early regressive lesions in the myocardium of sheep and cattle experimentally poisoned by MF through immunohistochemistry with troponin C (cTnC). Fragments of the heart muscle from six cattle (three received, orally, single doses of 0.5 mg/kg and the others, single doses of 1.0 mg/kg) and five sheep (one received, orally, single dose of 0.5 mg/kg, the other two received single doses of 1.0 mg/kg, one received sublethal daily doses of 0.1 mg/kg for four days, and another received daily sublethal doses of 0.2 mg/kg for six days) were submitted to immunohistochemistry with antibody anti-cTnC. In the cardiomyocites of cattle and sheep, it was possible to observe reduction of the expression levels for cTnC in the cytoplasm of groups of cardiac muscle fibers. Significant reduction of immunoreactivity ocurred overall in cardiomyocites that presented high cytoplasmic eosinophilia. The decrease or absence of expression. for cTnC in animals poisoned by MF allowed to estabilish the difference between coagulative necrosis of cardiomyocites and artifacts caused by fixation. This indicates that this method can be used safely to identify any lesions, early regressive or not, in the myocardium independently of the cause. It is also possible to affirm that poisoning by MF as well as the one caused by ?sudden death? causing plants can progress with regressive myocardial lesionsAo que tudo indica, o monofluoroacetato de s?dio (MF) ? o princ?pio t?xico das numerosas plantas que causam ?morte s?bita? no Brasil. Eventualmente, observam-se, nos animais intoxicados por MF, grupos de cardiomi?citos com aumento da eosinofilia citoplasm?tica. Essas altera??es card?acas, no entanto, na maioria dos casos, ainda incipientes, de dif?cil interpreta??o e sem rea??o inflamat?ria, devem ser diferenciadas de artefato. O presente trabalho teve como objetivo detectar a presen?a de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados experimentalmente por MF, atrav?s da imuno-histoqu?mica com troponina C (cTnC). Fragmentos de cora??o de seis bovinos (tr?s que receberam, por via oral, doses ?nicas de 0,5 mg/kg e, os demais, 1,0 mg/kg de MF) e cinco ovinos (um recebeu, por via oral, dose ?nica de 0,5 mg/kg, outros dois receberam doses de 1,0 mg/kg; um ovino recebeu, por via oral, doses subletais repetidas diariamente de 0,1 mg/kg/dia, por quatro dias, e outro, 0,2 mg/kg/dia por seis dias) foram submetidos ? t?cnica de imuno-histoqu?mica com anticorpo anti-cTnC. Nos mioc?rdios de bovinos e ovinos verificou-se redu??o dos n?veis de express?o da cTnC no citoplasma de grupos de fibras musculares. Diminui??o significativa na imunorreatividade ocorreu, sobretudo, em cardiomi?citos que apresentavam, no exame histopatol?gico, aumento da eosinofilia citoplasm?tica. A diminui??o ou aus?ncia da express?o da cTnC nos animais intoxicados por MF permitiu estabelecer a diferen?a entre necrose coagulativa de cardiomi?citos e artefato ocasionado pelo fixador. Isso indica que este m?todo pode ser utilizado com seguran?a para identifica??o de quaisquer les?es regressivas precoces, ou n?o, no mioc?rdio, independentemente da causa. Adicionalmente, ? poss?vel afirmar que, dependendo do tempo de evolu??o, a toxicose por MF, bem como por plantas causadoras de morte s?bita em bovinos e ovinos, podem cursar com les?es regressive no mioc?rdio.Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2019-11-21T12:27:49Z No. of bitstreams: 1 2015 - Andr? Marandola dos Santos.pdf: 2085474 bytes, checksum: e5edd9ad5b9aa14dcc928262a7e7964d (MD5)Made available in DSpace on 2019-11-21T12:27:49Z (GMT). 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Marandola dos Santos.pdf: 2085474 bytes, checksum: e5edd9ad5b9aa14dcc928262a7e7964d (MD5) Previous issue date: 2015-02-25Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttps://tede.ufrrj.br/retrieve/11470/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/16850/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/23164/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/29540/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/35914/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/42314/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/48696/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpghttps://tede.ufrrj.br/retrieve/55146/2015%20-%20Andr%c3%a9%20Marandola%20dos%20Santos.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riaABBAS, A. 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dc.title.por.fl_str_mv Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
dc.title.alternative.eng.fl_str_mv Troponin C in immunohistochemical detection of early regressive myocardial lesions in cattle and sheep poisoned with sodium monofluoroacetate.
title Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
spellingShingle Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
Santos, Andr? Marandola dos
Plantas t?xicas
monofluoroacetato
mioc?rdio
imuno-histoqu?mica
troponina C
intoxica??o por plantas
bovinos
ovinos
Poisonous plants
monofluoroacetate
myocardial lesions
immunohistochemistry
troponin C
plant poisoning
Castle
sheep.
Medicina Veterin?ria
title_short Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
title_full Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
title_fullStr Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
title_full_unstemmed Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
title_sort Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio
author Santos, Andr? Marandola dos
author_facet Santos, Andr? Marandola dos
author_role author
dc.contributor.advisor1.fl_str_mv Nogueira, Vivian de Assun??o
dc.contributor.advisor1ID.fl_str_mv 089.375.877-93
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6012855368365110
dc.contributor.advisor-co1.fl_str_mv Peixoto, Paulo Vargas
dc.contributor.advisor-co1ID.fl_str_mv 270.761.210-34
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/3002512195318611
dc.contributor.referee1.fl_str_mv Caldas, Saulo Andrade
dc.contributor.referee2.fl_str_mv D?bereiner, J?rgen
dc.contributor.authorID.fl_str_mv 136.187.587-90
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1341170071765519
dc.contributor.author.fl_str_mv Santos, Andr? Marandola dos
contributor_str_mv Nogueira, Vivian de Assun??o
Peixoto, Paulo Vargas
Caldas, Saulo Andrade
D?bereiner, J?rgen
dc.subject.por.fl_str_mv Plantas t?xicas
monofluoroacetato
mioc?rdio
imuno-histoqu?mica
troponina C
intoxica??o por plantas
bovinos
ovinos
topic Plantas t?xicas
monofluoroacetato
mioc?rdio
imuno-histoqu?mica
troponina C
intoxica??o por plantas
bovinos
ovinos
Poisonous plants
monofluoroacetate
myocardial lesions
immunohistochemistry
troponin C
plant poisoning
Castle
sheep.
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Poisonous plants
monofluoroacetate
myocardial lesions
immunohistochemistry
troponin C
plant poisoning
Castle
sheep.
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Sodium monofluoroacetate (MF) is the toxic principle of several plants that cause ?sudden death? of cattle in Brazil. Groups of cardiomyocites with high cytoplasmic eosinophilia are sometimes observed in animals poisoned by MF. However, this cardiac alteration is difficult to interpret and as there is no inflammatory reaction, it must be differentiated from artifacts. The present study had the objective to detect the presence of early regressive lesions in the myocardium of sheep and cattle experimentally poisoned by MF through immunohistochemistry with troponin C (cTnC). Fragments of the heart muscle from six cattle (three received, orally, single doses of 0.5 mg/kg and the others, single doses of 1.0 mg/kg) and five sheep (one received, orally, single dose of 0.5 mg/kg, the other two received single doses of 1.0 mg/kg, one received sublethal daily doses of 0.1 mg/kg for four days, and another received daily sublethal doses of 0.2 mg/kg for six days) were submitted to immunohistochemistry with antibody anti-cTnC. In the cardiomyocites of cattle and sheep, it was possible to observe reduction of the expression levels for cTnC in the cytoplasm of groups of cardiac muscle fibers. Significant reduction of immunoreactivity ocurred overall in cardiomyocites that presented high cytoplasmic eosinophilia. The decrease or absence of expression. for cTnC in animals poisoned by MF allowed to estabilish the difference between coagulative necrosis of cardiomyocites and artifacts caused by fixation. This indicates that this method can be used safely to identify any lesions, early regressive or not, in the myocardium independently of the cause. It is also possible to affirm that poisoning by MF as well as the one caused by ?sudden death? causing plants can progress with regressive myocardial lesions
publishDate 2015
dc.date.issued.fl_str_mv 2015-02-25
dc.date.accessioned.fl_str_mv 2019-11-21T12:27:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Andr? Marandola dos. Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio. 2015. 59 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3099
identifier_str_mv SANTOS, Andr? Marandola dos. Troponina C na detec??o imuno-histoqu?mica de altera??es regressivas precoces no mioc?rdio de bovinos e ovinos intoxicados por monofluoroacetato de s?dio. 2015. 59 f. Disserta??o (Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
url https://tede.ufrrj.br/jspui/handle/jspui/3099
dc.language.iso.fl_str_mv por
language por
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