Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae

Taran, Fernanda Melo Pereira

Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae

Detalhes bibliográficos
Autor(a) principal:	Taran, Fernanda Melo Pereira
Data de Publicação:	2016
Tipo de documento:	Tese
Idioma:	por
Título da fonte:	Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo:	https://tede.ufrrj.br/jspui/handle/jspui/1363
Resumo:	This study aimed to evaluate the in vitro adsorption of fumonisin B1 (FB1) through the use of different strains and concentrations of Saccharomyces cerevisiae in conditions simulating the digestive tract of horses. The experimental design was completely randomized in a factorial 4x5 with four yeast strains (1, 2, 3 and 4) and five concentrations for each strain of 1x107, 5x107, 1x108, 5x108 and 1x109 CFU.mL-1 at pH 2 and 6.8 with three replicates per treatment. In vitro adsorption experiments were carried out in microcentrifuge tubes containing buffered solution mycotoxin and yeast at 39 ? C. The concentration of FB1 was 5 ?g.mL-1. The supernatant of samples containing fumonisin not adsorbed were analyzed and quantified by CLAE. The results of the in vitro adsorption were subjected to a regression analysis based on the S. cerevisiae concentration and yeast strains. It was observed at pH 2 and 6.8 a significant interaction between S. cerevisiae concentration and yeast strain (P <0.001). At pH 2, the the amount of FB1 adsorbed by different yeast strains did not differ with 1x107, 5x107, 1x108 CFU.mL-1, only showed effects for the highest concentrations of 5x108 and 1x109 CFU.mL-1 (P<0.001). At pH 6.8, the differences occurred to concentration of 1x108, 5x108 and 1x109 CFU.mL-1 (P<0.001), but had no effect on lower concentrations (5x107 and 1x107 celulas.mL-1). At the highest concentration of 1x109 CFU.mL-1, strain 4 (SC-47) demonstrated a greater capacity to adsorb FB1, 39.4% and 37.5% at pH 2.0 and 6.8, respectively. In addition, linear responses were observed in the adsorption capacity in all strains evaluated under conditions of acidic and neutral pH. The results demonstrate that the ability of S. cerevisiae to adsorb FB1 is strain-dependent and the pH value may influence the amount of FB1 removed from the solution according to the strain used

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spelling	Almeida, Fernando Queiroz de579.744.627-87http://lattes.cnpq.br/2139243762106923Silva, Vinicius Pimentel297.639.108-46http://lattes.cnpq.br/1899895022524077Ven?ncio, Armando Albino Diashttp://lattes.cnpq.br/5109407867649093keller, Kelly MouraAronovich, MarcosRosa, Carlos Alberto da RochaSantos, Tiago Marques dos321.297.618-79http://lattes.cnpq.br/0566724602947013Taran, Fernanda Melo Pereira2017-01-10T11:33:17Z2016-01-06Taran, Fernanda Melo Pereira. Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae. 2016. [74 f.]. Tese( PROGRAMA DE P?S-GRADUA??O EM ZOOTECNIA) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica-RJ] .https://tede.ufrrj.br/jspui/handle/jspui/1363This study aimed to evaluate the in vitro adsorption of fumonisin B1 (FB1) through the use of different strains and concentrations of Saccharomyces cerevisiae in conditions simulating the digestive tract of horses. The experimental design was completely randomized in a factorial 4x5 with four yeast strains (1, 2, 3 and 4) and five concentrations for each strain of 1x107, 5x107, 1x108, 5x108 and 1x109 CFU.mL-1 at pH 2 and 6.8 with three replicates per treatment. In vitro adsorption experiments were carried out in microcentrifuge tubes containing buffered solution mycotoxin and yeast at 39 ? C. The concentration of FB1 was 5 ?g.mL-1. The supernatant of samples containing fumonisin not adsorbed were analyzed and quantified by CLAE. The results of the in vitro adsorption were subjected to a regression analysis based on the S. cerevisiae concentration and yeast strains. It was observed at pH 2 and 6.8 a significant interaction between S. cerevisiae concentration and yeast strain (P <0.001). At pH 2, the the amount of FB1 adsorbed by different yeast strains did not differ with 1x107, 5x107, 1x108 CFU.mL-1, only showed effects for the highest concentrations of 5x108 and 1x109 CFU.mL-1 (P<0.001). At pH 6.8, the differences occurred to concentration of 1x108, 5x108 and 1x109 CFU.mL-1 (P<0.001), but had no effect on lower concentrations (5x107 and 1x107 celulas.mL-1). At the highest concentration of 1x109 CFU.mL-1, strain 4 (SC-47) demonstrated a greater capacity to adsorb FB1, 39.4% and 37.5% at pH 2.0 and 6.8, respectively. In addition, linear responses were observed in the adsorption capacity in all strains evaluated under conditions of acidic and neutral pH. The results demonstrate that the ability of S. cerevisiae to adsorb FB1 is strain-dependent and the pH value may influence the amount of FB1 removed from the solution according to the strain usedAvaliou-se a adsor??o in vitro de fumonisina B1 (FB1) atrav?s do uso de diferentes cepas e concentra??es de Saccharomyces cerevisiae em condi??es que simulam o trato digestivo de equinos. O delineamento experimental foi inteiramente casualizado em esquema fatorial 4x5, com quatro cepas de levedura (1, 2, 3 e 4) e cinco concentra??es para cada cepa de 1x107, 5x107, 1x108, 5x108 e 1x109 UFC.mL-1, sob pH 2 e 6,8 com tr?s repeti??es por tratamento. Os ensaios de adsor??o in vitro foram conduzidos em microtubos contendo solu??o tamponada de micotoxina e levedura a 39 ?C. A concentra??o de FB1 foi de 5 ?g.mL-1. As amostras do sobrenadante contendo as fumonisinas n?o adsorvidas foram analisadas e quantificadas por CLAE. Os resultados foram submetidos ? an?lise de regress?o em fun??o da concentra??o de levedura e cepas de levedura. Observou-se, tanto em pH 2 como a 6,8, intera??o significativa entre concentra??o de FB1 e cepa de levedura (P<0,001). No pH 2, as cepas de levedura n?o diferiram em rela??o a quantidade de FB1 adsorvida nas concentra??es de 1x107, 5x107, 1x108 UFC.mL-1, apenas apresentaram efeito significativo para as concentra??es mais elevadas de 5x108 e 1x109 UFC.mL-1 (P<0,001). Em pH 6,8, as diferen?as ocorreram para as concentra??es de 1x108, 5x108 e 1x109 UFC.mL-1 (P<0,001), n?o apresentando efeito significativo nas concentra??es mais baixas (1x107e 5x107 UFC.mL-1). Na concentra??o mais elevada de 1x109 UFC.mL-1, a cepa 4 (SC-47) demonstrou maior capacidade para adsorver FB1, 39,4% e 37,5% em pH 2,0 e 6,8, respectivamente. Al?m disso, foram observadas respostas lineares na capacidade de adsor??o em todas as cepas avaliadas sob condi??es de pH ?cido e neutro. Os resultados demonstram que a capacidade de adsor??o de FB1 pela S. cerevisiae ? cepa-dependente e que o valor de pH pode influenciar na quantidade de FB1 removida da solu??o de acordo a cepa utilizada.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2017-01-10T11:33:17Z No. of bitstreams: 1 2016 - Fernanda Melo Pereira Taran.pdf: 1274160 bytes, checksum: 1abefb4abb6f8800458c7eb63d22a94c (MD5)Made available in DSpace on 2017-01-10T11:33:17Z (GMT). No. of bitstreams: 1 2016 - Fernanda Melo Pereira Taran.pdf: 1274160 bytes, checksum: 1abefb4abb6f8800458c7eb63d22a94c (MD5) Previous issue date: 2016-01-06Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttps://tede.ufrrj.br/retrieve/5053/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/19740/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/26055/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/32500/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/38840/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/45248/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/51608/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpghttps://tede.ufrrj.br/retrieve/58110/2016%20-%20Fernanda%20Melo%20Pereira%20Taran.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em ZootecniaUFRRJBrasilInstituto de Zootecnia3 REFER?NCIAS BIBLIOGR?FICAS ALMEIDA, F. Q.; SILVA, V. P. Progresso Cient?fico em Equideocultura na 1? D?cada do S?culo XXI. Revista Brasileira de Zootecnia, v. 39, p. 119-129, 2010. 16 ARMANDO, M.R.; DOGI, C.A.; PIZZOLITTO, R.P.; ESCOBAR, F. PEIRANO, M.S.; SALVANO, M.A. SABINI, L.I.; COMBINA, M.; DALCERO, A.M.; CAVAGLIERI, L. R. Saccharomyces cerevisiae strains from animal environment with in vitro aflatoxin B1 binding ability and anti-pathogenic bacterial influence. World Mycotoxin Journal, v. 4, n. 1, p. 59-68, 2011. ARMANDO, M.R.; GALVAGNO, M.A.; DOGI, C.A.; CERRUTTI, P.; DALCERO, A.M.; CAVAGLIERI, L. R. Statistical optimization of culture conditions for biomass production of probiotic gut-borne Saccharomyces cerevisiae strain able to reduce fumonisin B1. Journal of Applied Microbiology, v.114, p.1338-1346, 2013. BARROS, C.S.L.; BARROS, S.S.; SANTOS, M.N.; SOUZA, M.A. Leucoencefalomal?cia em equinos no Rio Grande do Sul. Pesquisa Veterin?ria Brasileira, v. 4, p.101-107, 1994. BATH, R.; RAI, R.V.; KARIM, A.A. Mycotoxins in Food and Feed: Present Status and Future Concerns. Comprehensive Reviews in Food Science and Food Safety, v.9, p.57-81, 2010. BENNETT, J. W.; KLICH, M. Mycotoxins. Clinical Microbiology Reviews, v.16, n.3, p. 497?516, 2003. BERTHILLER, F.; CREWS, C.; DALL'ASTA, C.; SAEGER, S.D.; HAESAERT, G.; KARLOVSKY, P.; STROKA, J. Masked mycotoxins: A review. Molecular Nutrition & Food Research, v. 57, p.165-186, 2013. BEZUIDENHOUT, S.C.; GELDERBLOM, W.C.A.; GORST-ALLMAN, C.P.; HORAK, R.M.; MARASAS, W.F.O.; SPITELLER, G.; VLEGGAAR, R. Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. Journal of the Chemical Society, v.11, p.743?745, 1988. BHATNAGAR, D.; TAKAHASHI, T.; CHANG, P.K.; MATUSIHIMA, K.; YU, J.; ABE, K.;CLEVELAND, T.E.; KOYAMA, Y. Mycotoxins: Current issues in U.S.A. Meeting the Mycotoxin Menace Book, 2003. 603 p. BOUHET, S.; HOURCADE, E.; LOISEAU, N.; FIKRY, A.; MARTINEZ, S.; ROSELLI, M.; GALTIER, P.; MENGHERI, E.; OSWALD, I.P. The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicological Science, v.77, p.165?171, 2004. BRADY, D.; STOLL, A.D.; STARKE, L.E; DUNCAN, J.R. Chemical and enzymatic extraction of heavy-metal binding polymers from isolated cell-walls of Saccharomyces cerevisiae. Biotechnology and Bioengineering, v. 44, n. 3, p. 297-302, 1994. BRASIL. O Minist?rio da Agricultura, Pecu?ria e Abastecimento. Portaria n? 130, 24 de maio de 2006. Grupo de Trabalho sobre Micotoxinas em produtos destinados ? alimenta??o animal. Di?rio Oficial da Uni?o da Rep?blica Federativa do Brasil, Bras?lia, Distrito Federal, 25 de maio de 2006, Se??o 2, p. 5. BRASIL. A Ag?ncia Nacional de Vigil?ncia Sanit?ria. Resolu??o RDC n?7, 18 de fevereiro de 2011. Regulamento t?cnico sobre limites m?ximos tolerados para micotoxinas em alimentos. Di?rio Oficial da Uni?o da Rep?blica Federativa do Brasil, Bras?lia, Distrito Federal, 22 de fevereirode 2011, Se??o 1, p. 72. BRITO, L. A. B.; NOGUEIRA, R. H. G.; PEREIRA, J. J.; CHIQUILOFF, M. A. G.; BIONDINI, J. Leucoencefalomalacia em equino associada ? ingest?o de milho mofado. Arquivo da Escola de Veterin?ria da UFMG, v.34, p.49-53, 1982. 17 BUENO, D.; CASALE, C.; PIZZOLITTO, R.; SALVANO, M.; OLIVER, G. Physical adsorption of aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: A theoretical model. Journal of Food Protection, v.70, n.9, p.2148-2154, 2007. CALONI, F.; CORTINOVIS, C. Effects of fusariotoxins in the equine species. Veterinary Journal, v.186, n.2, p.157-61, 2010. C?MARA A.C.L.; AFONSO J.A.B.; RIET-CORREA F.; DANTAS A.F.M.; MENDON?A C.L.; COSTA N.A.; DANTAS A.C.; COSTA NETO H.A.; CAMPOS A.N.S.S.; M.I., SOUZA. Leucoencefalomal?cia em equ?deos no Estado de Pernambuco. Ci?ncia Animal Brasileira, v.9, n.2, p.476-479, 2008. CAST, 2003. Mycotoxins: Risks in plant, animal, and human systems. Council of Agricultural Science and Technology, Task Force Report No. 139. 2003, 199 p. CELYK, K.; DENLY, M.; SAVAS, T. Reduction of toxic effects of aflatoxin by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicken diets. Revista Brasileira de Zootecnia, v.32, p.615?619, 2003. CHELULE, P.K.; GQALENI, N.; CHUTURGOON, A.A.; DUTTON, M.F. The determination of fumonisin B1 in faeces: a short term marker for assessment of exposure. Biomarkers, v.5, n.1, p.1-8, 2000. CHULZE, S. N. Strategies to reduce mycotoxin levels in maize during storage: a review. Food Additives and Contaminants, v. 27, n. 5, p. 651?665, 2010. COEURET, V.; GUEGUEN, M.; VERNOUX, J. P. Numbers and strains of Llactobacilli in some probiotic products. International Journal of Food Microbiology, v.97, p.147?156, 2004 COLEMAN, J.; BLAKE-KALFF, M.; DAVIES, E. Detoxification of xenobiotics by plants; chemical modification and vacuolar compartmentation. Trends in Plant Science, v.2, p.144?1251, 1997. CONAB - Companhia Nacional de Abastecimento. Acompanhamento da safra brasileira de gr?os: Safra 2013/14 ? Bras?lia, 2014, 92p. D?MELLO, J.P.F.; PLACINTA, C.M.; MaCDONALD, A.M.C. Fusarium mycotoxins: a review of global implications for animal health, welfare and productivity. Animal Feed Science and Technololy, v. 80, p.183?205, 1999. DALL?ASTA, C.; FALAVIGNA, C.; GALAVERNA, G.; BATTILANI, P. Role of maize hybrids and their chemical composition in Fusarium infection and Fumonisin production. Journal of Agricultural and Food Chemistry, v.60, p.3800?3808, 2012. DALL?ASTA, C.; FALAVIGNA, C.; GALAVERNA, G.; DOSSENA, A.; MARCHELLI, R. In vitro digestion assay for determination of hidden fumonisins in maize. Journal of Agricultural and Food Chemistry, v. 58, p.12042?12047, 2010. DE GROOT, P.W.J.; RAM, A.F.; KLIS, F.M. Features and functions of covalently linked proteins in fungal cell walls. Fungal Genetics and Biology, v. 42, n. 8, p. 657-675, 2005. DEL FAVA, C.; LARA, M.C.C.S.H.; VILLALOBOS, E.M.C.; NASSAR, A.F.C.; CABRAL, A.D.; TORELLI, C.S.; CUNHA, M.S.; CUNHA, E.M.S. Ocorr?ncia de leucoencefalomal?cia (LEME) em equ?deos no estado de S?o Paulo, Brasil: achados anatomopatol?gicos. Brazilian Journal of Veterinary Research and Animal Science, v.47, n.6, p.488-494, 2010. 18 DIAZ, D.E., SMITH, T.K. Mycotoxin sequestering agents: practical tools for the neutralisation of mycotoxins. In: DIAZ, D.E. (Ed.) The Mycotoxin Blue Book. United Kingdom: Nottingham University Press, 2005. p. 323-340. DIAZ, D.E.; HAGLER, W.M.; BLACKWELDER, J.T.; HOPKINS, B.A.; ANDERSEN, K.L. Aflatoxin blinders II: reduction of aflatoxin M1 in milk by sequestering agents of cows consuming aflatoxin in feed. Mycopathologia, v. 157, n. 2, p. 233-241, 2004. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to deoxynivalenol (DON) as undesirable substance in animal feed. The EFSA Journal, v.73, p.1-42, 2004a. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in Food Chain on a request from the Commission related to ochratoxin A 588 (OTA) as undesirable substance in animal feed. The EFSA Journal, v.101, p.1-36, 2004b. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to zearalenone as undesirable substance in animal feed. The EFSA Journal, v.89, p.1-34, 2004c. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to fumonisins as undesirable substances in animal feed. The EFSA Journal, v.235, p.1-32, 2005. EFSA - European Food Safety Authority. Scientific opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxins in food and feed. The EFSA Journal, v.9, n.12, p.1-187, 2011. ELSENHANS, B.; BLUME, R.; LEMBCKE, B.E.; CASPARY, W.F. Polycations: a new class of inhibitors for in vitro small intestinal transport of sugars and aminoacids in the rat. Biochimica et Biophysica Acta, v.727, p.135-143, 1983. FERRANTE, M.C.; MELI, R.; MATTACE, R.G.; ESPOSITO, E.; SEVERINO, L.; DI CARLO, G.; LUCISANO, A. Effetts of fumonisin B1 on structure and function of macrophage plasma membrane. Toxicology Letters, v.129, p.181-187, 2002. FINK-GREMMELS, J.; SPRONK, L. Hygienic quality of feed: implications of feed contamination with moulds and mycotoxins on equine health and performance. In: 6th European Equine Health and Nutrition Congress, 2013, Belgium. Proceedings of 6th European Equine Health and Nutrition Congress, 2013, p. 63-74. FINK-GREMMELS, J. Mycotoxins: Their implications for human and animal health. Veterinary Quarterly, v.21, p.115-120, 1999. FOREMAN, J.H.; CONSTABLE, P.D.; WAGGONER, A.L.; LEVY, M.; EPPLEY, R.M.; SMITH, G.W.; TUMBLESON, M.E.; HASCHEK, W.M. Neurologic abnormalities and cerebrospinal fluid changes in horses administered fumonisin B1 intravenously. Journal of Veterinary Internal Medicine, v.18, p.223?230, 2004. GALTIER, P. Biotransformation and fate of mycotoxins. Journal of Toxicology-Toxin Reviews, v.18, p.295?312, 1999. GELDERBLOM, W.C.A.; JASKIEWICZ, K.; MARASAS, W.F.O.; THIEL, P.G.; HORAK, M.J.; VLEGGAAR, R.; KRIEK, N.P.J. Fumonisins?novel mycotoxins with cancer promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology, v.54, p.1806?1811, 1988. 19 GRATZ, S.; MYKKANEN, H.; OUWEHAND, A. C.; JUVONEN, R.; SALMINEN, S.; EL-NEZAMI, H. Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. Applied and Environmental Microbiology, v.70, p.6306?6308, 2004. GREGORI, R.; MERIGGI, P.; PIETRI, A.; FORMENTI, S.; BACCARINI, G.; BATTILANI, P. Dynamics of fungi and related mycotoxins during cereal storage in silo bags. Food Control, v.30, p.280-287, 2013. GRENIER, B.; OSWALD, I.P. Mycotoxin co-contamination of food and feed: Meta analysis of publications describing toxicological interactions. World Mycotoxin Journal, v.4, p.285?313, 2011. GUSILS, C.; BUJAZHA, M.; GONZ?LEZ, S. Preliminary studies to design a probiotic for use in swine feed. Interciencia, v. 27, n. 8, p. 409-413, 2002. HASKARD, C. A.; EL-NEZAMI, H. S.; KANKAANPAA, P. E.; SALMINEN, S.; AHOKAS, J. T. Surface binding of alfatoxin B1 by lactic acid bacteria. Applied and Environmental Microbiology, 67, 3086?3091, 2001. HASKARD, C.; BINNION, C.; AHOKAS, J. Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chemico-Biological Interactions, v.128, p.39?49, 2000. HE, J.; ZHOU, T.; YOUNG, J. C.; BOLLAND, G. J. Chemical and biological transformations of trichothecene mycotoxins in human and animal food chains: a review. Trends in Food and Science Technology, v.21, p.67?76, 2010. HERNANDEZ-MENDOZA, A.; GARCIA, H.S.; STEELE, J.L. Screening of Lactobacillus casei strains for their ability to bind aflatoxin B1. Food and Chemical Toxicology, v.47, p.1064-1068, 2009. HIROOKA, E. Y.; VIOTTI, N. M. A.; SOARES, L. M. V.; ALFIERI, A. L. Intoxica??o em equinos por micotoxinas produzidas por Fusarium moniliforme no norte do Paran?. Semina, v. 9, p.128-135, 1988. HIROOKA, E.Y.; VIOTTI, N.M.A.; MAROCHI, M.A.; ISHII, K.; UENO, Y. Leucoencefalomal?cia em equinos no norte do Paran?. Revista de Microbiologia, v. 21, p. 223-227, 1990. HOPMANS, H.C.; HAUCK, C.C.; HENDRICH, S.E.; MURPHY, P.A. Excretion of fumonisin B1-fructose adduct in rats. Journal of Agricultural and Food Chemistry, v.45, p.2618-2625, 1997. HUSSEIN, H.S.; BRASEL, J.M. Toxicity, metabolism and impact of mycotoxins on humans and animals. Toxicology, v. 167, n. 2, p. 101-134, 2001. HUWIG, A.; FREIMUND, S.; KAPPELI, O.; DUTLER, H. Mycotoxin detoxication of animal feed by different adsorbents. Toxicology Letters, v. 122, n. 2, p. 179- 188, 2001. JOUANY, J.P.; YIANNINKOURIS, A.; BERTIN, G. How yeast cell wall components can alleviate micotoxicosis in animal production and improve the safety of edible animal products. Journal of Animal and Feed Sciences, v. 14, suppl 1., p. 171- 191, 2005. KELLER, K.M.; QUEIROZ, B.D.; KELLER, L.A.M.; RIBEIRO, J.M.M.; CAVAGLIERI, L.R.; PEREYRA, M.L.G.; DALCERO, A.M.; ROSA, C.A.R. The mycobiota and toxicity of equine feeds. Veterinary Research Communications, v. 31, n. 8, p. 1037- 1045, 2007. 20 KELLERMAN, T. S.; MARASAS, W. F. O.; THIEL, P. G.; GELDERBLOM, W. C. A.; CAWOOD, M.; COETZER, A.W. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort Journal of Veterinary Research, v.57, n.4, p. 269-275, 1999. KIM, E.K.; SCOTT, P.M.; LAU, B.P. Hidden fumonisin in cornflakes. Food Additives and Contaminants, v.20, p.161-169, 2003. K?HLE, A.; SKOVGAARD, K.Y.; JESPERSEN, L. In vitro screening of probiotic properties of Saccharomyces cerevisiae var. boulardii and food borne Saccharomyces cerevisiae strains. International Journal of Food Microbiology, v. 101, n. 1, p. 29-39, 2004. KUIPER-GOODMAN, T. Food safety: mycotoxins and phycotoxins in perspective. In: Miraglia, M.; Van Egmond, H.; Brera, C.; Gilbert, J. (eds.). Mycotoxins and phycotoxins?developments in chemistry, toxicology and food safety. Oxford, United Kingdom, International Union of Pure and Applied Chemistry (IUPAC), 1998, p. 25-48. LAHTINEN, S. J.; HASKARD, C. A.; OUWEHANDZ, A. C.; SALMINENZ, S. J.; AHOKASY, J. T. Binding of aflatoxin B1 to cell wall components of Lactobacillus rhamnosus strain GG. Food Additives and Contaminants, v.21, p.158?164, 2004. LALLES, J.P.; LESSARD, M.; OSWALD, I.P.; DAVID, J.C. Consumption of fumonisin B1 for 9 days induces stress proteins along the gastrointestinal tract of pigs. Toxicon, v.55, p.244?249, 2010. LEE, Y., EL-NEZAMI, H., HASKARD, C., GRATZ, S., PUONG, K., SALMINEN, S. & MYKK?NEN, H. Kinetics of adsorption and desorption of aflatoxin B1 by viable and nonviable bacteria. Journal of Food Protection, v.66, n.3, p.426-430, 2003. LESSARD, M.; BOUDRY, G.; SEVE, B.; OSWALD, I.P.; LALLES, J.P. Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins. Journal of Nutrition, v.139, p.1303?1307, 2009. LIESENER, K.; CURTUI, V.; DIETRICH, R.; M?RTLBAUER, E.; USLEBER, E. Mycotoxins in horse feed. Mycotoxin Research, v. 26, p.23?30, 2010. LIMA, R.A.S.; SHIROTA, R.; BARROS, G.S.C. Estudo do complexo do agroneg?cio cavalo. 1 Ed. Piracicaba: ESALQ/USP, 2006, 250p. LINO, C.M.; SILVA, L.J.G.; PENA, A.S. Evaluation of fumonisins exposure: biomarkers. Revista Portuguesa de Ci?ncias Veterin?rias, v.102, p. 5-15, 2004. LOISEAU, N.; DEBRAUWER, L.; SAMBOU, T.; BOUHET, S.; MILLER, J.D.; MARTIN, P.G.; VIADERE, J.L.; PINTON, P.; PUEL, O.; PINEAU, T.; TULLIEZ, J.; GALTIER, P.; OSWALD, I.P. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage. Biochemical and Pharmacology, v.74, n.1, p.144-152, 2007. MALLMANN, C. A.; SANTURIO, J. M.; DILKIN, P. Leucoencefalomal?cia equina associada ? ingest?o de milho contaminado por fumonisina B1. Revista de Microbiologia, v. 30, n. 3, p. 249-252, 1999. MALLMANN, C.A.; SANTURIO, J.M.; ALMEIDA, C.A.A.; DILKIN, P. Fumonisin B1 levels in cereals and feeds from southern Brazil. Arquivos do Instituto Biol?gico, v.68, n.1, p. 41-45, 2001. MANSFIELD, M.A.; JONES, A.D., KULDAU, G.A. Contamination of fresh and ensiled maize by multiple Penicillium mycotoxins. Phytopathology, v.98, p.330-336, 2008. 21 MAPA - Minist?rio da Agricultura, Pecu?ria e Abastecimento. Proje??es do Agroneg?cio: Brasil 2012/2013 a 2022/2023. Assessoria de Gest?o Estrat?gica. Bras?lia, 2013, 96 p. MAPA - Minist?rio da Agricultura, Pecu?ria e Abastecimento. Instru??o Normativa N? 15, de 26 de maio de 2009. Dispon?vel em: http://extranet.agricultura.gov.br/sislegis/action/detalhaAto.do?method=consultarLegislacaoFederal. Acesso em 15 de abril de 2014. MARASAS, W.F.O.; KELLERMAN, T.S.; GELDERBLOM, W.C.A.; COETZER, J.A.;THIEL, P.G.; VAN DER LUGT, J.J. Leukoencephalomalacia in horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort Journal of Veterinary Research, v. 55, p.197-203, 1988. MARASAS, W.F.O.; RILEY, R.T.; HENDRICKS, K.A.; STEVENS, V.L.; SADLER, T.W.; GELINEAU-VAN WAES, J.; MISSMER, S.A.; CABRERA, J.; TORRES, O.; GELDERBLOM, W.C.A.; ALLEGOOD, J.; MART?NEZ, C.; MADDOX, J.; MILLER, J.D.; STARR, L.; SULLARDS, M.; ROMAN, A.V.; VOSS, K.A.; WANG, E.; MERRILL, A.H. Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin contaminated maize. Journal of Nutrition, v.134, p.711?716, 2004. MARTEAU, P.; MINEKUS, M.; HAVENNAR, R.; HUIS IN?T VELD, J.H.J. Survival of lactic acid bacterias in a dynamic model of the stomach and small intestine: validation and effects of bile. Journal of Dairy Science, v. 80, n. 6, p. 1031-1037, 1997. MAZIERO, M. T.; BERSOT, L.S. Micotoxinas em alimentos produzidos no Brasil. Revista Brasileira de Produtos Agroindustriais, v.12, n.1, p.89-99, 2010. MEIRELES, M. A.; CORR?A, B.; FISCHMAN, O.; GAMBALE, W.; PAULA, C. R.; CHACON-RECHE, N. O.; POZZI, C. R. Mycoflora of the toxic feeds associated with equine leucoencephalomalacia (ELEM) outbreaks in Brazil. Mycopathology, v. 127, p.183-188, 1994. M?NDEZ, M.C.; F. ; RIET-CORREA. Intoxica??es por Plantas e Micotoxinas. In: Riet-Corre,a F.; Schild, A.L.; Lemos, R.A.A.; Borges, J.R.J. (Eds). Doen?as dos Ruminantes e Equinos, v.2, p.99-222, 2007. MEYER, K.; MOHR, K.; BAUER, J.; HORN, P.; KOV?CS, M. Residue formation of fumonisin B1 in porcine tissues. Food Additives and Contaminants, v.20, n.7, p.639-647, 2003. MURPHY, P.A.; HENDRICH, S.; LANDGREN, C.; BRYANT, C.M. Food Mycotoxins: An Update. Journal of Food Science, v.71, n.5, p.51-65, 2006. NRC - NATIONAL RESEARCH COUNCIL. Nutrient requirements of horses. 6.ed. Rev. Washington, D.C.: National Academies Press, 2007, 341p. NEWMAN, K.E.; RAYMOND, S.L. Effects of mycotoxins in horses. In: Diaz, D.E. (Ed.) The Mycotoxin Blue Book. Nottingham University Press. 2005, p.57?76. PARK, J.W.; SCOTT, P.M.; LAU, B.P.; LEWIS, D.A. Analysis of heat-processed corn foods for fumonisins and bound fumonisins. Food Additives and Contaminants, v.21, p.1168-1178, 2004. 22 PATZAK, M.; DOSTALEK, P.; FOGARTY, R.V.; SAFARIK, I.; TOBIN, J.M. Development of magnetic biosorbents for metal uptake. Biotechnology Techniques, v. 11, n. 7, 483-487, 1997. PITT, J. I. Toxigenic fungi and mycotoxins. British Medical Bulletin, v.56, n.1, p.184-92, 2000. PIZZOLITTO R.P.; BUENO D.J.; ARMANDO M.R.; CAVAGLIERI L.; DALCERO A.M.; SALVANO M.A. Binding of aflatoxin B1 to lactic acid bacteria and Saccharomyces cerevisiae in vitro: a useful model to determine the most efficient microorganism. Intech Open Access Publisher, p.1-20, 2011. PIZZOLITTO, R.P.; SALVANO, M.A.; DALCERO, A.M.; Analysis of fumonisin B1 removal by microorganisms in co-ocurrence with aflatoxin B1 and the nature of the binding process. International Journal of Food Microbiology, v.4156, p.214-221, 2012. PRELUSKY, D.B.; MILLER, J.D.; TRENHOLM, H.L. Disposition of 14C-derived residues in tissues of pigs fed radiolabelled fumonisin B1. Food Additives and Contaminants, v.13, n.2, p.155-162, 1996. RAGSDAL, J.M.; B.M., DEBEY. Equine leucoencephalomalacia linked to contamined corn. Kansas University Agricultural Experiment Station and Cooperative Extension Service, v. 6, n. 2, p.1-6, 2003. RAMOS GIRONA, A.J.; ROSA, C.A.R.; CAVAGLIERI, L.R.; GUEDES, C.A. Legislaci?n e impacto econ?mico de las micotoxinas. In: RAMOS, A.J (Ed). Micotoxinas Y Micotoxicoses, 1 ed. AMV Editiones, 2011, Cap.18, -462p. RAYMOND, S.L.; SMITH, T.K.; SWAMY, H.V.L.N. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on feed intake, serum chemistry, and hematology of horses, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. Journal of Animal Science, v.81, p.2123?2130, 2003. REGO CHAVES, L. Doen?a de sintomatologia nervosa causada pela intoxica??o pelo milho. Revista Medicina Veterin?ria, v. 10, p. 199-217, 1950. RIET-CORREA, F.; MEIRELES, M. A.; SOARES, J. M.; MACHADO, J. J.; ZAMBRANO, A. F. Leucoencefalomal?cia associada ? ingest?o de milho mofado. Pesquisa Veterin?ria Brasileira, v. 2, p.27-30, 1982. RIET-CORREA, F.; TABOSA, I. M.; AZEVEDO, E. O.; MEDEIROS, R. M. T.; SIM?ES, S. V. D.; DANTAS, A. A.; ALVES, J. C.; NOBRE, V. M. T.; ATHAYLDE, A. C.; GOMES, A. A.; LIMA, E. F. Doen?as de ruminantes e equinos no semi-?rido da Para?ba. Semi-?rido em Foco, v.1, p.2-86, 2003. RIET-CORREA, G.; DUARTE, M. D.; CERQUEIRA, V. D.; RIET-CORREA, F. Leucoencephalomalacia in mules in Northern Brazil, In: PANTER, K. E.; WIERENGA, T. L.; PFISTER, J. A. Poisonous plants: global research and solutions. CABI Publishing, p. 256-262, 2007. RILEY, R.T.; PESTKA, J.; DIAZ, D.E. Mycotoxins: metabolism, mechanisms and biochemical markers. The mycotoxin blue book, p. 279-294, 2005. RODR?GUEZ-AMAYA, D.B.; SABINO, M. Mycotoxin research in Brazil: the last decade in review. Brazilian Journal of Microbiology, v.33, p.1-11, 2002. ROSS, P.F.; LEDET, A.E.; OWENS, D.L.; RICE, L.G.; NELSON, H.A.; OSWEILER, G.D.; WILSON, T.M. Experimental equine leukoencephalomalacia, toxic hepatosis, and 23 encephalopathy caused by corn naturally contaminated with fumonisins. Journal of Veterinary Diagnostic Investigation, v.5, n.1, p.69-74, 1993. ROSS, P.F.; RICE, L.G.; REAGOR, J.C.; OSWEILER, G.D.; WILSON, T.M.; NELSON, H.A.; OWENS, D.L.; PLATTNER, R.D.; HARLIN, K.A.; RICHARD, J.L.; COLVIN, B.M.; BANTON, M.I. Fumonisin B1 concentrations in feeds from 45 confirmed equine leukoencephalomalacia cases. Journal of Veterinary Diagnostic Investigation, v.3, p.238?241, 1991. SALLES-GOMES, T.L.; ALMEIDA, P.E.; MOREIRA, M.; CANOLA, J.C.; CANOLA, P.A.; SOUZA, H.A. Surto de leucoencefalomal?cia equina provocada por ra??o comercial com concentra??o de fumonisina inferior a 10 ppm. ARS Veterin?ria, v.19, n.3, p.267-271, 2003. SANTOS, C.E.P.; SOUTO, F.S.M.; SANTURIO, J.M.; MARQUES, L.C. Leucoencefalomal?cia em equ?deos da regi?o Leste de Mato Grosso. Acta Scientiae Veterinariae, v.41, p.1119-1124, 2013. SHEPHARD, G.S. Impact of mycotoxins on human health in developing countries. Food Additives & Contaminants, v.25, n.2, p.146?151, 2008. SHEPHARD, G.S.; P.W., SNIJMAN. Elimination and excretion of a single dose of a mycotoxin fumonisin B2 in a non-human primate. Food and Chemical Toxicology, v. 37, p.111-116, 1999. SHETTY, P.H.; HALD, B.Y; JESPERSEN, L. Surface binding of aflatoxin B1 by Saccharomyces cerevisiae strains with potential decontaminating abilities in indigenous fermented foods. International Journal of Food Microbiology, v. 113, n. 1, p. 41-46, 2007. SHETTY, P.H.; JESPERSEN, L. . Saccharomyces cerevisiae and lactic acid bacteria as potential mycotoxin decontaminating agents. Trends in Food Science and Technology, v.17, p.48?55, 2006. SINDIRA??ES - Sindicato Nacional da Ind?stria de Alimenta??o Animal. Boletim informativo do setor de alimenta??o animal/ maio 2014. Consultado em 14/05/2014 em: http://sindiracoes.org.br/wp-content/uploads/2014/05/boletim-informativo-do-setor_vs-portugues_site-08052014.pdf SMITH, G.W.; CONSTABLE, P.D.; FOREMAN, J.H.; EPPLEY, R.M.; WAGGONER, A.L.; TUMBLESON, M.E.; HASCHEK, W.M. Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses. American Journal of Veterinary Research, V.63, p.538?545, 2002. STOCKMANN-JUVALA, H.; SAVOLAINEN, K.,. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & Experimental Toxicology, v.27, p.799?809, 2010. STREIT, E.; SCHATZMAYR, G.; TASSIS, P.; TZIKA, E.; MARIN, D.; TARANU, I.; TABUC, C.; NICOLAU, A.; APRODU, I.; PUEL, O.; OSWALD, I.P. Current situation of mycotoxin contamination and co-occurrence in animal feed ? focus on Europe. Toxins, v.4, p.788-809, 2012. TELLER, R.S.; SCHMIDT, R.J.; WHITLOW, L.W.; KUNG, L.JR. Effect of physical damage to ears of corn before harvest and treatment with various additives on the concentration of mycotoxins, silage fermentation and aerobic stability of corn silage. Journal of Dairy Science, v.95, p.1428-1436, 2012. 24 THEUMER, M.G.; RUBINSTEIN, H.R. Interacciones de las micotoxinas. In: RAMOS, A.J. (ed). Mycotoxinas y micotoxicosis. 1ed. 2011, p.373-394. TRENHOLM, H.L.; FOSTER, B.C.; CHARMLEY, L.L.; THOMPSON, B.K.; HARTIN, K.E.; COPPOCK, R.W.; ALBASSAM, M.A. Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs. Canadian Journal of Animal Science, v.74, p.361?369, 1994. UNI?O EUROP?IA ? UE Directiva 2006/576/CE - Recomenda??o da Comiss?o de 17 de Agosto de 2006 sobre a presen?a de desoxinivalenol, zearalenona, ocratoxina A, toxinas T-2 e HT-2 e fumonisinas em produtos destinados ? alimenta??o animal. Jornal Oficial da Uni?o Europeia, L 229, p.7, 2006. UNI?O EUROP?IA ? UE Directiva 2002/32/CE do parlamento europeu e do Conselho de 7 de Maio de 2002 relativa ?s subst?ncias indesej?veis nos alimentos para animais, Jornal Oficial da Uni?o Europeia, L 140, p. 10, 30/5/2002. UNI?O EUROP?IA ? UE Directiva 2003/100/CE da Comiss?o de 31 de outubro de 2003 que altera o anexo I da Directiva 2002/32/CE do Parlamento Europeu e do Conselho relativa ?s subst?ncias indesej?veis nos alimentos para animais. Jornal Oficial da Uni?o Europeia, L 285, p. 33, 1/11/2003. VACLAVIKOVA, M.; MALACHOVA, A.; VEPRIKOVA, Z.; DZUMAN, Z.; ZACHARIASOVA, M.; HAJSLOVA, J. ?Emerging? mycotoxins in cereals processing chains: changes of enniatins during beer and bread making. Food Chemistry, v.136, p.170-757, 2013. VENDL, O.; BERTHILLER, F.; CREWS, C.; KRSKA, R. Simultaneous determination of deoxynivalenol, zearalenone and their major masked metabolites in cereal-based food by LC675 MS-MS. Analytical and Bioanalytical Chemistry, v.395, p.1347?1354, 2009. VOSS, K.A.; RILEY, R.T.; NORRED, W.P.; BACON, C.W.; MEREDITH, F.I.; HOWARD, P.C.; PLATTNER, R.D.; COLLINS, T.F.X.; HANSEN, D.K.; PORTER, J.K. An overview of rodent toxicities: Liver, and kidney effects of fumonisins and Fusarium moniliforme. Environmental Health Perspectives, v.109, p.259?266, 2001. VOSS, K.A.; SMITH, G.W.; HASCHEK, W.M. Fumonisins: toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology, v.137, p.299?325, 2007. WANG, E.; ROSS, P.; WILSON, T.; RILEY, R.; MERRILI, A. Increases in Serum Shingosine and Shinganine and Decreases in Complex Sphingolipids in Ponies Given Feed Containing Fumonisins, Mycotoxins Produced by Fusarium moniliforme. Journal of Nutrition, v. 122, p.1706 ? 1716, 1992 WEBSTER, J.; WEBER, R. Introduction to Fungi, 3 ed. Cambridge University Press, 2007, 867p. WEESE, J.A. Review of probiotics: Are they really ?Functional Foods??. Proceedings of the American Association of Equine Practitioners (AAEP, v. 47, p. 27-31, 2001. WILSON, T.M.; ROSS, P.F.; OWENS, D.L.; RICE, L.G.; JENKINS, S.J.; NELSON H.A. Experimental production of ELEM, a study to determine the minimum toxic dose in ponies. Mycopathology, v.117, p.115-120, 1992. WOLOSHUK, C.P.; SHIM, W.B. Aflatoxins, fumonisins and trichothecenes: a convergence of knowledge. FEMS Microbiology Letters, v.37, p.94-109, 2013. 25 XAVIER, J.G.; BRUNNER, C.H.M.; SAKAMOTO, M.; CORREA, B.; FERNANDES, W. R.; DIAS, J. L. C. Equine leucoencephalomalacia: report of five cases. Brazilian Journal of Veterinary Research and Animal Science, v. 28, p.185-189, 1991. YIANNIKOURIS, A.; FRAN?OIS, J.; POUGHON, L.; DUSSAP, C.G.; JEMINET, G.; JOUANY, J.P. Influence of pH on complexing of model beta-d-glucans with zearalenone. Journal of Food Protection, v.67, n.12, p.2741-6, 2004a. YIANNIKOURIS, A.; FRAN?OIS, J.; POUGHON, L.; DUSSAP, C.G.; BERTIN, G.; JEMINET, G.; JOUANY, J.P. Alkali extraction of ?-D-glucans from Saccharomyces cerevisiae cell wall and study of their adsorptive properties towards Zearalenone. Journal of Agricultural and Food Chemistry, v. 52, n. 11, p. 3666-3673, 2004b. YIANNIKOURIS, A.; FRANCOIS, J.; POUGHON, L.; DUSSAP, C.G.; JEMINET, G.; JOUANY, J.P. Adsortion of zearalenone by beta-D-glucans in the Saccharomyces cerevisiae cell wall. Journal of Food Protection, v. 67, n. 6, p. 1195-1200, 2004c. YIANNIKOURIS, A.; JOUANY, J.P. Mycotoxins in feeds and their fate in animals: a review. Animal Research, v.51, p.81-99, 2002. YIANNIKOURIS, A.; POUGHON, L.; CAMELEYRE, X.; DUSSAP, C.G.; FRANCOIS, J.; BERTIN, G.; JOUANY, J.P. A novel technique to evaluate interactions between Saccharomyces cerevisiae cell wall and mycotoxins: application to zearalenone. Biotechnology Letters, v. 25, n. 10, p. 783- 789, 2003. YIN, J.J.; SMITH, M.J.; EPPLEY, R.M.; PAGE, S.W.; SPHON, J.A. Effects of fumonisin B1 on lipid peroxidation in membranes. Biochimica et Biophysica Acta, v.1371, p.134-142, 1998. ZACHARIASOVA. M.; DZUMAN, Z.; VEPRIKOVA, Z.; HAJKOVA, K.; JIRU, M.; VACLAVIKOVA, M.; POSPICHALOVA, M.; FLORIAN, M.; HAJSLOVA, J. Occurrence of multiple mycotoxins in European feedingstuffs, assessment of dietary intake by farm animals. Animal Feed Science and Technology, v.193, p. 124-140, 2014. ZINEDINE, A.; SORIANO, J. M.; MOLT?, J. C.; MA?ES, J. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food and Chemical Toxicology, v.45, n.1, p.1-18, 2007. 6 REFER?NCIAS BIBLIOGR?FICAS ARMANDO, M.R.; DOGI, C.A.; PIZZOLITTO, R.P.; ESCOBAR, F. PEIRANO, M.S.; SALVANO, M.A. SABINI, L.I.; COMBINA, M.; DALCERO, A.M.; CAVAGLIERI, L.R. Saccharomyces cerevisiae strains from animal environment with in vitro aflatoxin B1 binding ability and anti-pathogenic bacterial influence. World Mycotoxin Journal, v. 4, n. 1, p. 59-68, 2011. 37 ARMANDO, M.R.; GALVAGNO, M.A.; DOGI, C.A.; CERRUTTI, P.; DALCERO, A.M.; CAVAGLIERI, L.R. Statistical optimization of culture conditions for biomass production of probiotic gut-borne Saccharomyces cerevisiae strain able to reduce fumonisin B1. Journal of Applied Microbiology, v.114, p.1338-1346, 2013. ARMANDO, M.R.; PIZZOLITTO, R.P.; DOGI, C.A.; CRISTOFOLINI, A.; MERKIS, C.; POLONI, V.; DALCERO, A.M.; CAVAGLIERI, L.R. Adsorption of ochratoxin A and zearalenone by potential probiotic Saccharomyces cerevisiae strains and its relation with cell wall thickness. Journal of Applied Microbiology, v.113, p.256-264, 2012. BUENO, D.; CASALE, C.; PIZZOLITTO, R.; SALVANO, M.; OLIVER, G. Physical adsorption of aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: A theoretical model. Journal of Food Protection, v.70, n.9, p.2148-2154, 2007. CALONI, F.; CORTINOVIS, C. Effects of fusariotoxins in the equine species. Veterinary Journal, v.186, n.2, p.157-61, 2010. EL-NEZAMI, H.; KANKAANPAA, P.; SALMINEN, S.; AHOKAS, J. Physicochemical alterations enhance the ability of dairy strains of lactic acid bacteria to remove aflatoxin from contaminated media. Journal of Food Protection, v.61, p.466?468, 1998. EL-NEZAMI, H.; POLYCHRONAKI, N.; SALMINEN, S.; MYKKANEN, H. Binding rather than metabolism may explain the interaction of two food-grade Lactobacillus strains with zearalenone and its derivative ?-zearalenol. Applied and Environmental Microbiology, v.68, p.3545-3549, 2002a. EL-NEZAMI, H.S.; CHREVATIDIS, A.; AURIOLA, S.; SALMINEN, S.; MYKKANEN, H. Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium. Food Additives and Contaminants, v.19, p.680-686, 2002b. FRUHAUF, S.; SCHWARTZ, H.; OTTNER, F.; KRSKA, R.; VEKIRU, E. Yeast cell based feed additives: studies on aflatoxin B1 and zearalenone. Food Additives and Contaminants: Part A, v. 29, n. 2, p. 217-231, 2012. GRATZ, S.; MYKKANEN, H.; OUWEHAND, A.C.; JUVONEN, R.; SALMINEN, S.; EL-NEZAMI, H. Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. Applied and Environmental Microbiology, v.70, p.6306-6308, 2004. GUSILS, C.; BUJAZHA, M.; GONZ?LEZ, S. Preliminary studies to design a probiotic for use in swine feed. Interciencia, v. 27, n. 8, p. 409-413, 2002. HARRISON, L.R.; COLVIN, B.M.; GREENE, J.T.; NEWMAN, L.E.; COLE, J.R. Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. Journal of Veterinary Diagnostic Investigation, v.2, n.3, p.217-221, 1990. HASKARD, C.A.; EL-NEZAMI, H.S.; KANKAANPAA, P.E.; SALMINEN, S.; AHOKAS, J.T. Surface binding of aflatoxin B1 by lactic acid bacteria. Applied and Environmental Microbiology, 67, 3086?3091, 2001. HASKARD, C.; BINNION, C.; AHOKAS, J. Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chemico-Biological Interactions, v.128, p.39-49, 2000. HERNANDEZ-MENDOZA, A., GARCIA, H.S.; STEELE, J.L. Screening of Lactobacillus casei strains for their ability to bind aflatoxin B1. Food and Chemical Toxicology, v.47, p.1064-1068, 2009. 38 HUWIG, A.; FREIMUND, S.; KAPPELI, O.; DUTLER, H. Mycotoxin detoxication of animal feed by different adsorbents. Toxicology Letters, v.122, n.2, p.179-188, 2001. IARC - INTERNATIONAL AGENCY FOR RESEARCH ON CANCER. IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans: Some Traditional Herbal Medicines, some Mycotoxins, Naphthalene and Styrene. International Agency for Research on Cancer, v.82, p.301-366, 2002. JOUANY, J.P.; YIANNINKOURIS, A.; BERTIN, G. How yeast cell wall components can alleviate micotoxicosis in animal production and improve the safety of edible animal products. Journal of Animal and Feed Sciences, v.14, suppl.1, p.171-191, 2005. K?HLE, A.; SKOVGAARD, K.Y.; JESPERSEN, L. In vitro screening of probiotic properties of Saccharomyces cerevisiae var. boulardii and food borne Saccharomyces cerevisiae strains. International Journal of Food Microbiology, v.101, n.1, p.29-39, 2004. LEE, Y., EL-NEZAMI, H., HASKARD, C., GRATZ, S., PUONG, K., SALMINEN, S.; MYKK?NEN, H. Kinetics of adsorption and desorption of aflatoxin B1 by viable and nonviable bacteria. Journal of Food Protection, v.66, n.3, p.426-430, 2003. NIDERKORN, V.; BOUDRA, H.; MORGAVI, D.P. Binding of Fusarium mycotoxins by fermentative bacteria in vitro. Journal of Applied Microbiology, v.101, p.849-856, 2006. NIDERKORN, V.; MORGAVI, D.P.; PUJOS, E.; TISSANDIER, A.; BOUDRA, H. Screening of fermentative bacteria for their ability to bind and biotransform deoxynivalenol, zearalenone and fumonisins in vitro simulated corn silage model. Food Additives and Contaminants, v.24, p.406-415, 2007. PEREYRA, C.M.; CAVAGLIERI, L.R.; CHIACCHIERA, S.M.; DALCERO, A. The corn influence on the adsorption levels of aflatoxin B1 and zearalenone by yeast cell wall. Journal of Applied Microbiology. v.114, p.655-662, 2012. PITT, J.I. Toxigenic fungi and mycotoxins. British Medical Bulletin, v.56, n.1, p.184-92, 2000. PIZZOLITTO R.P.; BUENO D.J.; ARMANDO M.R.; CAVAGLIERI L.; DALCERO A.M.; SALVANO M.A. Binding of aflatoxin B1 to lactic acid bacteria and Saccharomyces cerevisiae in vitro: a useful model to determine the most efficient microorganism. Intech Open Access Publisher, p.1-20, 2011. PIZZOLITTO, R.P.; SALVANO, M.A.; DALCERO, A.M.; Analysis of fumonisin B1 removal by microorganisms in co-occurrence with aflatoxin B1 and the nature of the binding process. International Journal of Food Microbiology, v.4156, p.214-221, 2012. SANCHIS, V.; ABADIAS, M.; ONCINS, L.; SALA, N.; VINAS, I.; CANELA, R. Fumonisins B1 and B2 and Toxigenic Fusarium Strains in Feeds from the Spanish Market. International Journal of Food Microbiology, v.27, p.37-44. 1995. SHETTY, P.H.; JESPERSEN, L. Saccharomyces cerevisiae and lactic acid bacteria as potential mycotoxin decontaminating agents. Trends in Food Science and Technology, v.17, p.48-55, 2006. STOLL, V.; BLANCHARD, J.S. Buffers: principles and practice. In: DEUSTSCHER, M.P. (ed.). Methods in Enzymology. Volume 182. Guide to protein purification, 1990, California. Academic Press, Inc., 1990, p.24-38. VOSS, K.A.; SMITH, G.W.; HASCHEK, W.M. Fumonisins: toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology, v.137, p.299-325, 2007. 39 YIANNIKOURIS, A.; FRAN?OIS, J.; POUGHON, L.; DUSSAP, C.G.; BERTIN, G.; JEMINET, G.; JOUANY, J.P. Alkali extraction of ?-D-glucans from Saccharomyces cerevisiae cell wall and study of their adsorptive properties towards Zearalenone. Journal of Agricultural and Food Chemistry, v.52, n.11, p.3666-3673, 2004b. YIANNIKOURIS, A.; FRAN?OIS, J.; POUGHON, L.; DUSSAP, C.G.; JEMINET, G.; JOUANY, J.P. Influence of pH on complexing of model beta-d-glucans with zearalenone. Journal of Food Protection, v.67, n.12, p.2741-2746, 2004a. YIANNIKOURIS, A.; POUGHON, L.; CAMELEYRE, X.; DUSSAP, C.G.; FRANCOIS, J.; BERTIN, G.; JOUANY, J.P. A novel technique to evaluate interactions between Saccharomyces cerevisiae cell wall and mycotoxins: application to zearalenone. Biotechnology Letters, v.25, n.10, p.783-789, 2003. YIANNIKOURIS, A.; ANDR?, G.; POUGHON, L.; FRAN?OIS, J.; DUSSAP, C.G.; JEMINET, G.; JOUANY, J.P. Chemical and conformational study of the interactions involved in mycotoxin complexation with ?-D-glucans. Biomacromolecules, v. 7, n. 4, p. 1147-1155, 2006. ZACHARIASOVA. M.; DZUMAN, Z.; VEPRIKOVA, Z.; HAJKOVA, K.; JIRU, M.; VACLAVIKOVA, M.; POSPICHALOVA, M.; FLORIAN, M.; HAJSLOVA, J. Occurrence of multiple mycotoxins in European feedingstuffs, assessment of dietary intake by farm animals. Animal Feed Science and Technology, v.193, p. 124-140, 2014. 6. REFER?NCIAS BIBLIOGR?FICAS ABDOULI, H.; BEN ATTIA, S. Evaluation of two-stage in vitro technique for estimating digestibility of equine feeds using horse faeces as the source of microbial inoculum. Animal Feed Science and Technology, v.132, p.155-162, 2007. AOAC - ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS. Official Methods of Analysis, 15th ed. AOAC, Washington, DC, USA, 1990. ARMANDO, M.R.; DOGI, C.A.; PIZZOLITTO, R.P.; ESCOBAR, F. PEIRANO, M.S.; SALVANO, M.A. SABINI, L.I.; COMBINA, M.; DALCERO, A.M.; CAVAGLIERI, L.R. Saccharomyces cerevisiae strains from animal environment with in vitro aflatoxin B1 binding ability and anti-pathogenic bacterial influence. World Mycotoxin Journal, v. 4, n. 1, p. 59-68, 2011. 54 ARMANDO, M.R.; GALVAGNO, M.A.; DOGI, C.A.; CERRUTTI, P.; DALCERO, A.M.; CAVAGLIERI, L.R. Statistical optimization of culture conditions for biomass production of probiotic gut-borne Saccharomyces cerevisiae strain able to reduce fumonisin B1. Journal of Applied Microbiology, v.114, p.1338?1346, 2013. ARMANDO, M.R.; PIZZOLITTO, R.P.; DOGI, C.A.; CRISTOFOLINI, A.; MERKIS, C.; POLONI, V.; DALCERO, A.M.; CAVAGLIERI, L.R. Adsorption of ochratoxin A and zearalenone by potential probiotic Saccharomyces cerevisiae strains and its relation with cell wall thickness. Journal of Applied Microbiology, v.113, p.256?264, 2012. BERTHILLER, F.; CREWS, C.; DALL'ASTA, C.; SAEGER, S.D.; HAESAERT, G.; KARLOVSKY, P.; OSWALD, I.P.; SEEFELDER, W.; SPEIJERS, G.; STROKA, J. Masked mycotoxins: A review. Molecular Nutrition & Food Research, v. 57, p.165-186, 2013. BRERA, C.; DEBEGNACH, F.; GROSSI, S.; MIRAGLIA, M. Effect of industrial processing on the distribution of fumonisin B1 in dry milling corn fractions. Journal of Food Protection, v.67, n6, p.1261?1266, 2004. BUENO, D.; CASALE, C.; PIZZOLITTO, R.; SALVANO, M.; OLIVER, G. Physical adsorption of aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: A theoretical model. Journal of Food Protection, v.70, n.9, p.2148-2154, 2007. BULLERMAN, L.B.; BIANCHINI, A. Stability of mycotoxins during food processing. International Journal of Food Microbiology, v.119, n1, p.140-146, 2007. CALONI, F.; CORTINOVIS, C. Effects of fusariotoxins in the equine species. Veterinary Journal, v.186, n.2, p.157-61, 2010. C?MARA A.C.L.; AFONSO J.A.B.; RIET-CORREA F.; DANTAS A.F.M.; MENDON?A C.L.; COSTA N.A.; DANTAS A.C.; COSTA NETO H.A.; CAMPOS A.N.S.S.; M.I., SOUZA. Leucoencefalomal?cia em equ?deos no Estado de Pernambuco. Ci?ncia Animal Brasileira, v.9, n.2, p.476-479, 2008. DALL?ASTA, C.; FALAVIGNA, C.; GALAVERNA, G.; DOSSENA, A.; MARCHELLI, R. In vitro digestion assay for determination of hidden fumonisins in maize. Journal of Agricultural and Food Chemistry, v. 58, p.12042?12047, 2010. DAWSON, K.A.; EVANS, J.; KUDUPOJE, M. Understanding the adsorption characteristics of yeast cell wall preparations associated with mycotoxin binding. In: LYONS, T.P.; JACQUES, K.A. (eds). Science and technology in the feed industry. Nottingham University Press UK., p.16-181, 2001. DIAZ, D.E.; SMITH, T.K. Mycotoxin sequestering agents: practical tools for the neutralisation of mycotoxins. In: DIAZ, D.E. (Ed.) The Mycotoxin Blue Book. United Kingdom: Nottingham University Press, 2005. p. 323-340. FRUHAUF, S.; SCHWARTZ, H.; OTTNER, F.; KRSKA, R.; VEKIRU, E. Yeast cell based feed additives: studies on aflatoxin B1 and zearalenone. Food Additives & Contaminants: Part A, v.29, n.2, p.217-231, 2012. GRATZ, S.; MYKKANEN, H.; OUWEHAND, A. C.; JUVONEN, R.; SALMINEN, S.; EL-NEZAMI, H. Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. Applied and Environmental Microbiology, v.70, p.6306?6308, 2004. HASKARD, C.; BINNION, C.; AHOKAS, J. Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chemico-Biological Interactions, v.128, p.39?49, 2000. 55 HASKARD, C.A.; EL-NEZAMI, H.S.; KANKAANPAA, P.E.; SALMINEN, S.; AHOKAS, J.T. Surface binding of aflatoxin B1 by lactic acid bacteria. Applied and Environmental Microbiology, 67, 3086?3091, 2001. HERNANDEZ-MENDOZA, A., GARCIA, H.S.; STEELE, J.L. Screening of Lactobacillus casei strains for their ability to bind aflatoxin B1. Food and Chemical Toxicology, v.47, p.1064-1068, 2009. KRUCKEBERG, A.L.; DICKINSON, J.R. Carbon metabolism. In: DICKINSON, J.R.; SCHWEIZER (eds). Metabolism and molecular physiology of Saccharomyces cerevisiae. CRC press, 2004, p.42-103. MALLMANN, C.A.; SANTURIO, J.M.; DILKIN, P. Leucoencefalomal?cia equina associada ? ingest?o de milho contaminado por fumonisina B1. Revista de Microbiologia, v. 30, n. 3, p. 249-252, 1999. PEREYRA, C.M., CAVAGLIERI, L.R., CHIACCHIERA, S.M., DALCERO, A. The corn influence on the adsorption levels of aflatoxin B1 and zearalenone by yeast cel wall. Journal of Applied Microbiology. v.114, p. 655-662, 2012. PIZZOLITTO, R.P.; BUENO, D.J.; ARMANDO, M.R.; CAVAGLIERI, L.; DALCERO, A.M.; SALVANO, M.A. Binding of aflatoxin B1 to lactic acid bacteria and Saccharomyces cerevisiae in vitro: a useful model to determine the most efficient microorganism. Intech online publishers, p.1-20, 2011. PIZZOLITTO, R.P.; SALVANO, M.A.; DALCERO, A.M.; Analysis of fumonisin B1 removal by microorganisms in co-occurrence with aflatoxin B1 and the nature of the binding process. International Journal of Food Microbiology, v.4156, p.214-221, 2012. RAGSDAL, J.M.; DEBEY, B.M. Equine leucoencephalomalacia linked to contaminated corn. Kansas University Agricultural Experiment Station and Cooperative Extension Service, v. 6, n. 2, p.1-6, 2003. ROBERTSON, J.B.; VAN SOEST, P.J. The detergent system of analysis. In: JAMES, W.P.T.; THEANDER, O. (EDS.). The Analysis of Dietary Fibre in Food, p. 123?158. 1981. ROSS, P.F.; RICE, L.G.; REAGOR, J.C.; OSWEILER, G.D.; WILSON, T.M.; NELSON, H.A.; OWENS, D.L.; PLATTNER, R.D.; HARLIN, K.A.; RICHARD, J.L.; COLVIN, B.M.; BANTON, M.I. Fumonisin B1 concentrations in feeds from 45 confirmed equine leukoencephalomalacia cases. Journal of Veterinary Diagnostic Investigation, v.3, p.238?241, 1991. SALLES-GOMES, T.L.; ALMEIDA, P.E.; MOREIRA, M.; CANOLA, J.C.; CANOLA, P.A.; SOUZA, H.A. Surto de leucoencefalomal?cia equina provocada por ra??o comercial com concentra??o de fumonisina inferior a 10 ppm. ARS Veterin?ria, v.19, n.3, p.267-271, 2003. SANCHIS, V.; ABADIAS, M.; ONCINS, L.; SALA, N.; VINAS, I.; CANELA, R. Fumonisins B1 and B2 and Toxigenic Fusarium Strains in Feeds from the Spanish Market. International Journal of Food Microbiology, V.27, p.37-44. 1995. SANTOS, C.E.P.; SOUTO, F.S.M.; SANTURIO, J.M.; MARQUES, L.C. Leucoencefalomal?cia em equ?deos da regi?o Leste de Mato Grosso. Acta Scientiae Veterinariae, v.41, p.1119-1124, 2013. SCOTT, P.M. Recent research on fumonisins: a review. Food Additives & Contaminants: Part A, v.29, n.2, p.242-248, 2012. 56 SHETTY, P.H.; HALD, B.Y; JESPERSEN, L. Surface binding of aflatoxin B1 by Saccharomyces cerevisiae strains with potential decontaminating abilities in indigenous fermented foods. International Journal of Food Microbiology, v. 113, n. 1, p. 41-46, 2007. SHETTY, P.H.; JESPERSEN, L. Saccharomyces cerevisiae and lactic acid bacteria as potential mycotoxin decontaminating agents. Trends in Food Science and Technology, v.17, p.48?55, 2006. STOLL, V.; BLANCHARD, J.S. Buffers: principles and practice. In: Deustscher, M.P. (ed.). Methods in enzymology. Volume 182 Guide to protein purification. 1990. California: Academic Press, Inc. p 24-38. SYDENHAM, E.W.; SHEPHARD, G.S.; THIEL, P.G.; STOCKENSTR?M, S.; SNIJMAN, P.W.; VAN SCHALKWYK, D.J. Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn. Journal of AOAC International v.79, p.688?696, 1996. SYDENHAM, E.W.; SHEPHARD, G.S.; THIEL, P.G.; STOCKENSTR?M, S.; SNIJMAN, P.W.; VAN SCHALKWYK, D.J. Liquid chromatographic determination of fumonisins B1. B2. and B3 in corn. Journal of AOAC International v.79. p.688?696. 1996. SZAB?-FODOR, J.; DALL'ASTA, C.; FALAVIGNA, C.; KACHLEK, M.; SZ?CSI, ?.; SZAB?, A.; KOV?CS, M. Determination of the amount of bioaccessible fumonisin B1 in different matrices after in vitro digestion. World Mycotoxin Journal, v.8, n.3, p.61-267, 2014. THEUMER, M.G.; RUBINSTEIN, H.R. Interacciones de las micotoxinas. In: RAMOS. A.J. (ed). Mycotoxinas y micotoxicosis. 1ed. 2011. p.373-394. VAN SOEST, P.J.; ROBERTSON J.P; LEWIS, B.A. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science, v.74, p.3583-3597, 1991. VAN SOEST, P.J.; ROBERTSON, J.P; LEWIS. B.A. Methods for dietary fiber. neutral detergent fiber. and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science. v.74. p.3583-3597. 1991. VOSS, K.A.; SMITH, G.W.; HASCHEK, W.M. Fumonisins: toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology, v.137, p.299?325, 2007. YIANNIKOURIS, A.; JOUANY, J.P. Mycotoxins in feeds and their fate in animals: a review. Animal Research, v.51, p.81-99, 2002. 6 REFER?NCIAS BIBLIOGR?FICAS BERTHILLER, F.; CREWS, C.; DALL'ASTA, C.; SAEGER, S.D.; HAESAERT, G.; KARLOVSKY, P.; STROKA, J. Masked mycotoxins: A review. Molecular Nutrition & Food Research, v. 57, p.165-186, 2013. BOUHET, S.; HOURCADE, E.; LOISEAU, N.; FIKRY, A.; MARTINEZ, S.; ROSELLI, M.; GALTIER, P.; MENGHERI, E.; OSWALD, I.P. The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicological Science, v.77, p.165?171, 2004. BUENO, D.; CASALE, C.; PIZZOLITTO, R.; SALVANO, M.; OLIVER, G. Physical adsorption of aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: A theoretical model. Journal of Food Protection, v.70, n.9, p.2148-2154, 2007. CALONI, F.; CORTINOVIS, C. Effects of fusariotoxins in the equine species. Veterinary Journal, v.186, n.2, p.157-61, 2010. CALONI, F.; SPOTTI, M..; AUERBACH, H.; DEN CAMP, H.O.; HREMMELS, J.F.; POMPA, G. In Vitro metabolism of fumonisin B1 by ruminal microflora. Veterinary Research Communications, v.24, p.379-387, 2000. COLEMAN, J.; BLAKE-KALFF, M.; DAVIES, E. Detoxification of xenobiotics by plants; chemical modification and vacuolar compartmentation. Trends in Plant Science, v.2, p.144?1251, 1997. CONE, J.W.; VAN GELDER, A.H.; VISSCHER, G.J.W.; OUDSHOORN, L. Influence of rumen fluid and substrate concentration on fermentation kinetics measured with a fully automated time related gas production apparatus. Animal Feed Science and Technology, v.61, p.113?128, 1996. CONWAY, E.J. Microdiffusion. Analysis and volumetric error. 2nd Edition, Crosby Lockwood and Son, London. 1950. CZERKAWSKI, J.W. The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro. British Journal Nutrition, v.36, p.311?315, 1976. DALY, K.; PROUDMAN, C.J.; DUNCAN, S.H.; FLINT, H.J.; DYER, J.; SHIRAZI-BEECHEY, S.P. Alterations in microbiota and fermentation products in equine large intestine 70 in response to dietary variation and intestinal disease. British Journal of Nutrition, v.107, n.07, p.989-995, 2012. de FOMBELLE, A.; VARLOUD, M.; GOACHET, A.G.; JACOTOT, E.; JACOTOT, C.; PHILIPPEAU, C.; JULLIAND, V. Characterization of the microbial and biochemical profile of the different segments of the digestive tract in horses given two distinct diets. Animal Science. v.77, p.293-304, 2003. EL-NEZAMI, H.; KANKAANPAA, P.; SALMINEN, S.; AHOKAS, J. Physicochemical alterations enhance the ability of dairy strains of lactic acid bacteria to remove aflatoxin from contaminated media. Journal of Food Protection, v.61, p.466?468, 1998. FODOR, J.; MEYER, K.; GOTTSCHALK, C.; MAMET, R.; KAMETLER, L.; BAUER, J.; KOVACS, M. In vitro microbial metabolism of fumonisin B1. Food additives and contaminants, v.24, n.4, p.416-420, 2007. GALTIER, P. Biotransformation and fate of mycotoxins. Journal of Toxicology-Toxin Reviews, v.18, p.295?312, 1999. GUSILS, C.; BUJAZHA, M.; GONZ?LEZ, S. Preliminary studies to design a probiotic for use in swine feed. Interciencia, v.27, n.8, p.409-413, 2002. HASKARD, C.A.; EL-NEZAMI, H.S.; KANKAANPAA, P.E.; SALMINEN, S.; AHOKAS, J.T. Surface binding of alfatoxin B1 by lactic acid bacteria. Applied and Environmental Microbiology, v.67, p.3086?3091, 2001. HASKARD, C.; BINNION, C.; AHOKAS, J. Factors affectting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chemico-Biological Interactions, v.128, p.39?49, 2000. HE, J.; ZHOU, T.; YOUNG, J. C.; BOLLAND, G. J. Chemical and biological transformations of trichothecene mycotoxins in human and animal food chains: a review. Trends in Food and Science Technology, v.21, p.67?76, 2010. HERNANDEZ-MENDOZA, A.; GARCIA, H.S.; STEELE, J.L. Screening of Lactobacillus casei strains for their ability to bind aflatoxin B1. Food and Chemical Toxicology, v.47, p.1064-1068, 2009. JOUANY, J.P.; GOBERT, J.; MEDINA, B.; BERTIN, G.; JULLIAND, V. Effect of live yeast culture supplementation on apparent digestibility and rate of passage in horses fed a high-fiber or fight-starch diet. Journal of Animal Science. v.86, p.39-347. 2008. JOUANY, J.P.; MEDINA, B.; BERTIN, G.; JULLIAND, V. Effect of live yeast culture supplementation on hindgut microbial communities and their polysaccharidase and glycoside hydrolase activities in horses fed a high-fiber or high-starch diet. Journal of Animal Science. v.86, p.39-347. 2009. JULLIAND V,; PHILLIPSON, C.; GOACHET, A.G.; RALSTON, S. Physiology of intake and digestion in equine animals. In: Nutrition of the Exercising Horse. European Association for Animal Production 125. Wageningen Academic Publishers, The Netherlands, 2008, p.53-70. JULLIAND, V.; FOMBELLE, A.; DROUGOUL, C.; JACOTOT, E. Feeding and microbial disorders in horses: 3: effects of three hay: grain ratios on microbial profile and activities. Journal of Equine Veterinary Science. v.21, n.11, p. 543-546. 2001. 71 JULLIAND, V.; DE VAUX, A.; MILLET, L.; FONTY, G. Identification of Ruminococcus flavefaciens as the predominant cellulolytic bacterial species of the equine cecum. Applied and environmental microbiology, v.65, n.8, p.3738-3741, 1999. K?HLE, A.; SKOVGAARD, K.Y.; JESPERSEN, L. In vitro screening of probiotic properties of Saccharomyces cerevisiae var. boulardii and food borne Saccharomyces cerevisiae strains. International Journal of Food Microbiology, v.101, n.1, p.29-39, 2004. LEE, Y.; EL-NEZAMI, H.; HASKARD, C.; GRATZ, S.; PUONG, K.; SALMINEN, S.; MYKK?NEN, H. Kinetics of adsorption and desorption of aflatoxin B1 by viable and nonviable bacteria. Journal of Food Protection, v.66, n.3, p.426-430, 2003. LEEDLE, J.A.; HESPELL, R.B. Differential carbohydrate media and anaerobic replica plating techniques in delineating carbohydrate-utilizing subgroups in rumen bacterial populations. Applied and Environmental Microbiology, v.39, n.4, p. 709-719, 1980. LIESENER, K.; CURTUI, V.; DIETRICH, R.; M?RTLBAUER, E.; USLEBER, E. Mycotoxins in horse feed. Mycotoxin Research, v.26, p.23?30, 2010. MACKIE, R.I.; HEATH S. Enumeration and isolation of lactate-utilizing bacteria from the rumen of sheep. Applied and environmental microbiology, v.38, n.3, p. 416-421, 1979. MEDINA, B.; GIRARD, I. D.; JACOTOT, E.; JULLIAND, V. Effect of a preparation of Saccharomyces cerevisae on microbial profiles and fermentation patterns in the large intestine o horses fed a high fiber or a high starch diet. Journal of Animal Science, v. 80, p. 2600-2609, 2002. MENKE, K.; RAAB, L.; SALEWSKI, A.; STEINGASS, H.; FRITZ, D.; SCHNEIDER, W. The estimation of the digestibility and metabolizable energy content of ruminant feedingstuffs from the gas production when they are incubated with rumen liquor in vitro. Journal of Agricultural Science, v.93, p.217?222, 1979. NRC - NATIONAL RESEARCH COUNCIL. Nutrient requirements of horses. 6.ed. Rev. Washington, D.C.: National Academies Press, 2007. 341p. NIDERKORN, V.; BOUDRA, H.; MORGAVI, D. P. Binding of Fusarium mycotoxins by fermentative bacteria in vitro. Journal of Applied Microbiology, v.101, n.4, p.849-856, 2006. PIZZOLITTO R.P.; BUENO D.J.; ARMANDO M.R.; CAVAGLIERI L.; DALCERO A.M.; SALVANO M.A. Binding of aflatoxin B1 to lactic acid bacteria and Saccharomyces cerevisiae in vitro: a useful model to determine the most efficient microorganism. Intech online publishers, p1-20, 2011. PIZZOLITTO, R.P.; SALVANO, M.A.; DALCERO, A.M.; Analysis of fumonisin B1 removal by microorganisms in co-ocurrence with aflatoxin B1 and the nature of the binding process. International Journal of Food Microbiology, v.4156, p.214-221, 2012. PRELUSKY, D.B.; MILLER, J.D.; TRENHOLM, H.L. Disposition of 14C-derived residues in tissues of pigs fed radiolabelled fumonisin B1. Food Additives and Contaminants, v.13, n.2, p.155-162, 1996. RICE, L.G.; ROSS, P.F. Methods for detection and quantitation of fumonisins in corn, cereal products and animal excreta. Journal of Food Protection?, v.57, n.6, p.536-540, 1994. RILEY, R. T.; ENONGENE, E.; VOSS, K. A.; NORRED, W. P.; MEREDITH, F. I.; SHARMA, R. P.; SPITSBERGEN, J.; WILLIAMS, D. E.; CARLSON, D. B.; MERRILL, A. 72 H. JR. Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environmental Health Perspectives, v.109, p.301?308, 2005. ROSS, P.F.; RICE, L.G.; REAGOR, J.C.; OSWEILER, G.D.; WILSON, T.M.; NELSON, H.A.; OWENS, D.L.; PLATTNER, R.D.; HARLIN, K.A.; RICHARD, J.L.; COLVIN, B.M.; BANTON, M.I. Fumonisin B1 concentrations in feeds from 45 confirmed equine leukoencephalomalacia cases. Journal of Veterinary Diagnostic Investigation, v.3, p.238?241, 1991. SALLES-GOMES, T.L.; ALMEIDA, P.E.; MOREIRA, M.; CANOLA, J.C.; CANOLA, P.A.; SOUZA, H.A. Surto de leucoencefalomal?cia equina provocada por ra??o comercial com concentra??o de fumonisina inferior a 10 ppm. ARS Veterin?ria, v.19, n.3, p.267-271, 2003. SANCHIS, V.; ABADIAS, M.; ONCINS, L.; SALA, N.; VINAS, I.; CANELA, R. Fumonisins B1 and B2 and Toxigenic Fusarium Strains in Feeds from the Spanish Market. International Journal of Food Microbiology, v.27, p.37-44. 1995. SANTOS, A.S.; RODRIGUES, M.A.M.; BESSA, R.J.B.; FERREIRA, L.M.; MARTIN-ROSSET, W. Understanding the equine cecum-colon ecosystem: current knowledge and future perspectives. Animal, v.5, n.01, p.48-56, 2011 SHEPHARD, G.S.; P.W., SNIJMAN. Elimination and excretion of a single dose of a mycotoxin fumonisin B2 in a non-human primate. Food and Chemical Toxicology, v.37, p.111-116, 1999. SHEPHARD, G.S.; THIEL, P.G.; SYDENHAM, E.W.; SAVARD, M.E. Fate of a single dose of [14C]-labelled fumonizin B1 in vervet monkeys. Natural Toxins, v.3, p. 145?150, 1995. SHETTY, P.H.; HALD, B.Y; JESPERSEN, L. Surface binding of aflatoxin B1 by Saccharomyces cerevisiae strains with potential decontaminating abilities in indigenous fermented foods. International Journal of Food Microbiology, v.113, n.1, p.41-46, 2007. SHETTY, P.H.; JESPERSEN, L. Saccharomyces cerevisiae and lactic acid bacteria as potential mycotoxin decontaminating agents. Trends in Food Science and Technology, v.17, p.48?55, 2006. SMITH, J.S.; THAKUR, R.A. Occurrence and fate of fumonisins in beef. In: Fumonisins in Food. Springer US, 1996. p.39-55. SRICHANA, D.; ROTTINGHAUS, G.E.; SRICHANA, P.; PORTER, J.H.; KERLEY, M.S.; LEDOUX, D.R.; ELLERSIECK, M.R.. Effect of fumonisin on growth of ruminal bacteria in batch culture. Thammasat International Journal of Science and Technology, v. 14, n. 2, 2009. VOSS, K.A.; RILEY, R.T.; NORRED, W.P.; BACON, C.W.; MEREDITH, F.I.; HOWARD, P.C.; PLATTNER, R.D.; COLLINS, T.F.X.; HANSEN, D.K.; PORTER, J.K. An overview of rodent toxicities: Liver, and kidney effects of fumonisins and Fusarium moniliforme. Environmental Health Perspectives, v.109, p.259?266, 2001. VOSS, K.A.; SMITH, G.W.; HASCHEK, W.M. Fumonisins: toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology, v.137, p.299?325, 2007. WALKER, C.E.; DROUILLARD, J.S. Effects of catecholamines on gut microflora and potential for beta-adrenergic agonists to impact ruminal fermentation. 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dc.title.por.fl_str_mv	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
dc.title.alternative.eng.fl_str_mv	Fumonisin B1 in horse nutrition: digestive interactions in vitro systems and the effect of Saccharomyces cerevisiae as adsorbent
title	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
spellingShingle	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae Taran, Fernanda Melo Pereira adsorbent capacity yeast mycotoxin. capacidade adsorvente levedura micotoxina Ci?ncias Agr?rias
title_short	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
title_full	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
title_fullStr	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
title_full_unstemmed	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
title_sort	Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae
author	Taran, Fernanda Melo Pereira
author_facet	Taran, Fernanda Melo Pereira
author_role	author
dc.contributor.advisor1.fl_str_mv	Almeida, Fernando Queiroz de
dc.contributor.advisor1ID.fl_str_mv	579.744.627-87
dc.contributor.advisor1Lattes.fl_str_mv	http://lattes.cnpq.br/2139243762106923
dc.contributor.advisor-co1.fl_str_mv	Silva, Vinicius Pimentel
dc.contributor.advisor-co1ID.fl_str_mv	297.639.108-46
dc.contributor.advisor-co1Lattes.fl_str_mv	http://lattes.cnpq.br/1899895022524077
dc.contributor.advisor-co2.fl_str_mv	Ven?ncio, Armando Albino Dias
dc.contributor.advisor-co2Lattes.fl_str_mv	http://lattes.cnpq.br/5109407867649093
dc.contributor.referee1.fl_str_mv	keller, Kelly Moura
dc.contributor.referee2.fl_str_mv	Aronovich, Marcos
dc.contributor.referee3.fl_str_mv	Rosa, Carlos Alberto da Rocha
dc.contributor.referee4.fl_str_mv	Santos, Tiago Marques dos
dc.contributor.authorID.fl_str_mv	321.297.618-79
dc.contributor.authorLattes.fl_str_mv	http://lattes.cnpq.br/0566724602947013
dc.contributor.author.fl_str_mv	Taran, Fernanda Melo Pereira
contributor_str_mv	Almeida, Fernando Queiroz de Silva, Vinicius Pimentel Ven?ncio, Armando Albino Dias keller, Kelly Moura Aronovich, Marcos Rosa, Carlos Alberto da Rocha Santos, Tiago Marques dos
dc.subject.eng.fl_str_mv	adsorbent capacity yeast mycotoxin.
topic	adsorbent capacity yeast mycotoxin. capacidade adsorvente levedura micotoxina Ci?ncias Agr?rias
dc.subject.por.fl_str_mv	capacidade adsorvente levedura micotoxina
dc.subject.cnpq.fl_str_mv	Ci?ncias Agr?rias
description	This study aimed to evaluate the in vitro adsorption of fumonisin B1 (FB1) through the use of different strains and concentrations of Saccharomyces cerevisiae in conditions simulating the digestive tract of horses. The experimental design was completely randomized in a factorial 4x5 with four yeast strains (1, 2, 3 and 4) and five concentrations for each strain of 1x107, 5x107, 1x108, 5x108 and 1x109 CFU.mL-1 at pH 2 and 6.8 with three replicates per treatment. In vitro adsorption experiments were carried out in microcentrifuge tubes containing buffered solution mycotoxin and yeast at 39 ? C. The concentration of FB1 was 5 ?g.mL-1. The supernatant of samples containing fumonisin not adsorbed were analyzed and quantified by CLAE. The results of the in vitro adsorption were subjected to a regression analysis based on the S. cerevisiae concentration and yeast strains. It was observed at pH 2 and 6.8 a significant interaction between S. cerevisiae concentration and yeast strain (P <0.001). At pH 2, the the amount of FB1 adsorbed by different yeast strains did not differ with 1x107, 5x107, 1x108 CFU.mL-1, only showed effects for the highest concentrations of 5x108 and 1x109 CFU.mL-1 (P<0.001). At pH 6.8, the differences occurred to concentration of 1x108, 5x108 and 1x109 CFU.mL-1 (P<0.001), but had no effect on lower concentrations (5x107 and 1x107 celulas.mL-1). At the highest concentration of 1x109 CFU.mL-1, strain 4 (SC-47) demonstrated a greater capacity to adsorb FB1, 39.4% and 37.5% at pH 2.0 and 6.8, respectively. In addition, linear responses were observed in the adsorption capacity in all strains evaluated under conditions of acidic and neutral pH. The results demonstrate that the ability of S. cerevisiae to adsorb FB1 is strain-dependent and the pH value may influence the amount of FB1 removed from the solution according to the strain used
publishDate	2016
dc.date.issued.fl_str_mv	2016-01-06
dc.date.accessioned.fl_str_mv	2017-01-10T11:33:17Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/doctoralThesis
format	doctoralThesis
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	Taran, Fernanda Melo Pereira. Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae. 2016. [74 f.]. Tese( PROGRAMA DE P?S-GRADUA??O EM ZOOTECNIA) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica-RJ] .
dc.identifier.uri.fl_str_mv	https://tede.ufrrj.br/jspui/handle/jspui/1363
identifier_str_mv	Taran, Fernanda Melo Pereira. Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae. 2016. [74 f.]. Tese( PROGRAMA DE P?S-GRADUA??O EM ZOOTECNIA) - Universidade Federal Rural do Rio de Janeiro, [Serop?dica-RJ] .
url	https://tede.ufrrj.br/jspui/handle/jspui/1363
dc.language.iso.fl_str_mv	por
language	por
dc.relation.references.por.fl_str_mv	3 REFER?NCIAS BIBLIOGR?FICAS ALMEIDA, F. Q.; SILVA, V. P. Progresso Cient?fico em Equideocultura na 1? D?cada do S?culo XXI. Revista Brasileira de Zootecnia, v. 39, p. 119-129, 2010. 16 ARMANDO, M.R.; DOGI, C.A.; PIZZOLITTO, R.P.; ESCOBAR, F. PEIRANO, M.S.; SALVANO, M.A. SABINI, L.I.; COMBINA, M.; DALCERO, A.M.; CAVAGLIERI, L. R. Saccharomyces cerevisiae strains from animal environment with in vitro aflatoxin B1 binding ability and anti-pathogenic bacterial influence. World Mycotoxin Journal, v. 4, n. 1, p. 59-68, 2011. ARMANDO, M.R.; GALVAGNO, M.A.; DOGI, C.A.; CERRUTTI, P.; DALCERO, A.M.; CAVAGLIERI, L. R. Statistical optimization of culture conditions for biomass production of probiotic gut-borne Saccharomyces cerevisiae strain able to reduce fumonisin B1. Journal of Applied Microbiology, v.114, p.1338-1346, 2013. BARROS, C.S.L.; BARROS, S.S.; SANTOS, M.N.; SOUZA, M.A. Leucoencefalomal?cia em equinos no Rio Grande do Sul. Pesquisa Veterin?ria Brasileira, v. 4, p.101-107, 1994. BATH, R.; RAI, R.V.; KARIM, A.A. Mycotoxins in Food and Feed: Present Status and Future Concerns. Comprehensive Reviews in Food Science and Food Safety, v.9, p.57-81, 2010. BENNETT, J. W.; KLICH, M. Mycotoxins. Clinical Microbiology Reviews, v.16, n.3, p. 497?516, 2003. BERTHILLER, F.; CREWS, C.; DALL'ASTA, C.; SAEGER, S.D.; HAESAERT, G.; KARLOVSKY, P.; STROKA, J. Masked mycotoxins: A review. Molecular Nutrition & Food Research, v. 57, p.165-186, 2013. BEZUIDENHOUT, S.C.; GELDERBLOM, W.C.A.; GORST-ALLMAN, C.P.; HORAK, R.M.; MARASAS, W.F.O.; SPITELLER, G.; VLEGGAAR, R. Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. Journal of the Chemical Society, v.11, p.743?745, 1988. BHATNAGAR, D.; TAKAHASHI, T.; CHANG, P.K.; MATUSIHIMA, K.; YU, J.; ABE, K.;CLEVELAND, T.E.; KOYAMA, Y. Mycotoxins: Current issues in U.S.A. Meeting the Mycotoxin Menace Book, 2003. 603 p. BOUHET, S.; HOURCADE, E.; LOISEAU, N.; FIKRY, A.; MARTINEZ, S.; ROSELLI, M.; GALTIER, P.; MENGHERI, E.; OSWALD, I.P. The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicological Science, v.77, p.165?171, 2004. BRADY, D.; STOLL, A.D.; STARKE, L.E; DUNCAN, J.R. Chemical and enzymatic extraction of heavy-metal binding polymers from isolated cell-walls of Saccharomyces cerevisiae. Biotechnology and Bioengineering, v. 44, n. 3, p. 297-302, 1994. BRASIL. O Minist?rio da Agricultura, Pecu?ria e Abastecimento. Portaria n? 130, 24 de maio de 2006. Grupo de Trabalho sobre Micotoxinas em produtos destinados ? alimenta??o animal. Di?rio Oficial da Uni?o da Rep?blica Federativa do Brasil, Bras?lia, Distrito Federal, 25 de maio de 2006, Se??o 2, p. 5. BRASIL. A Ag?ncia Nacional de Vigil?ncia Sanit?ria. Resolu??o RDC n?7, 18 de fevereiro de 2011. Regulamento t?cnico sobre limites m?ximos tolerados para micotoxinas em alimentos. Di?rio Oficial da Uni?o da Rep?blica Federativa do Brasil, Bras?lia, Distrito Federal, 22 de fevereirode 2011, Se??o 1, p. 72. BRITO, L. A. B.; NOGUEIRA, R. H. G.; PEREIRA, J. J.; CHIQUILOFF, M. A. G.; BIONDINI, J. Leucoencefalomalacia em equino associada ? ingest?o de milho mofado. Arquivo da Escola de Veterin?ria da UFMG, v.34, p.49-53, 1982. 17 BUENO, D.; CASALE, C.; PIZZOLITTO, R.; SALVANO, M.; OLIVER, G. Physical adsorption of aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: A theoretical model. Journal of Food Protection, v.70, n.9, p.2148-2154, 2007. CALONI, F.; CORTINOVIS, C. Effects of fusariotoxins in the equine species. Veterinary Journal, v.186, n.2, p.157-61, 2010. C?MARA A.C.L.; AFONSO J.A.B.; RIET-CORREA F.; DANTAS A.F.M.; MENDON?A C.L.; COSTA N.A.; DANTAS A.C.; COSTA NETO H.A.; CAMPOS A.N.S.S.; M.I., SOUZA. Leucoencefalomal?cia em equ?deos no Estado de Pernambuco. Ci?ncia Animal Brasileira, v.9, n.2, p.476-479, 2008. CAST, 2003. Mycotoxins: Risks in plant, animal, and human systems. Council of Agricultural Science and Technology, Task Force Report No. 139. 2003, 199 p. CELYK, K.; DENLY, M.; SAVAS, T. Reduction of toxic effects of aflatoxin by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicken diets. Revista Brasileira de Zootecnia, v.32, p.615?619, 2003. CHELULE, P.K.; GQALENI, N.; CHUTURGOON, A.A.; DUTTON, M.F. The determination of fumonisin B1 in faeces: a short term marker for assessment of exposure. Biomarkers, v.5, n.1, p.1-8, 2000. CHULZE, S. N. Strategies to reduce mycotoxin levels in maize during storage: a review. Food Additives and Contaminants, v. 27, n. 5, p. 651?665, 2010. COEURET, V.; GUEGUEN, M.; VERNOUX, J. P. Numbers and strains of Llactobacilli in some probiotic products. International Journal of Food Microbiology, v.97, p.147?156, 2004 COLEMAN, J.; BLAKE-KALFF, M.; DAVIES, E. Detoxification of xenobiotics by plants; chemical modification and vacuolar compartmentation. Trends in Plant Science, v.2, p.144?1251, 1997. CONAB - Companhia Nacional de Abastecimento. Acompanhamento da safra brasileira de gr?os: Safra 2013/14 ? Bras?lia, 2014, 92p. D?MELLO, J.P.F.; PLACINTA, C.M.; MaCDONALD, A.M.C. Fusarium mycotoxins: a review of global implications for animal health, welfare and productivity. Animal Feed Science and Technololy, v. 80, p.183?205, 1999. DALL?ASTA, C.; FALAVIGNA, C.; GALAVERNA, G.; BATTILANI, P. Role of maize hybrids and their chemical composition in Fusarium infection and Fumonisin production. Journal of Agricultural and Food Chemistry, v.60, p.3800?3808, 2012. DALL?ASTA, C.; FALAVIGNA, C.; GALAVERNA, G.; DOSSENA, A.; MARCHELLI, R. In vitro digestion assay for determination of hidden fumonisins in maize. Journal of Agricultural and Food Chemistry, v. 58, p.12042?12047, 2010. DE GROOT, P.W.J.; RAM, A.F.; KLIS, F.M. Features and functions of covalently linked proteins in fungal cell walls. Fungal Genetics and Biology, v. 42, n. 8, p. 657-675, 2005. DEL FAVA, C.; LARA, M.C.C.S.H.; VILLALOBOS, E.M.C.; NASSAR, A.F.C.; CABRAL, A.D.; TORELLI, C.S.; CUNHA, M.S.; CUNHA, E.M.S. Ocorr?ncia de leucoencefalomal?cia (LEME) em equ?deos no estado de S?o Paulo, Brasil: achados anatomopatol?gicos. Brazilian Journal of Veterinary Research and Animal Science, v.47, n.6, p.488-494, 2010. 18 DIAZ, D.E., SMITH, T.K. Mycotoxin sequestering agents: practical tools for the neutralisation of mycotoxins. In: DIAZ, D.E. (Ed.) The Mycotoxin Blue Book. United Kingdom: Nottingham University Press, 2005. p. 323-340. DIAZ, D.E.; HAGLER, W.M.; BLACKWELDER, J.T.; HOPKINS, B.A.; ANDERSEN, K.L. Aflatoxin blinders II: reduction of aflatoxin M1 in milk by sequestering agents of cows consuming aflatoxin in feed. Mycopathologia, v. 157, n. 2, p. 233-241, 2004. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to deoxynivalenol (DON) as undesirable substance in animal feed. The EFSA Journal, v.73, p.1-42, 2004a. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in Food Chain on a request from the Commission related to ochratoxin A 588 (OTA) as undesirable substance in animal feed. The EFSA Journal, v.101, p.1-36, 2004b. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to zearalenone as undesirable substance in animal feed. The EFSA Journal, v.89, p.1-34, 2004c. EFSA - European Food Safety Authority. Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to fumonisins as undesirable substances in animal feed. The EFSA Journal, v.235, p.1-32, 2005. EFSA - European Food Safety Authority. Scientific opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxins in food and feed. The EFSA Journal, v.9, n.12, p.1-187, 2011. ELSENHANS, B.; BLUME, R.; LEMBCKE, B.E.; CASPARY, W.F. Polycations: a new class of inhibitors for in vitro small intestinal transport of sugars and aminoacids in the rat. Biochimica et Biophysica Acta, v.727, p.135-143, 1983. FERRANTE, M.C.; MELI, R.; MATTACE, R.G.; ESPOSITO, E.; SEVERINO, L.; DI CARLO, G.; LUCISANO, A. Effetts of fumonisin B1 on structure and function of macrophage plasma membrane. Toxicology Letters, v.129, p.181-187, 2002. FINK-GREMMELS, J.; SPRONK, L. Hygienic quality of feed: implications of feed contamination with moulds and mycotoxins on equine health and performance. In: 6th European Equine Health and Nutrition Congress, 2013, Belgium. Proceedings of 6th European Equine Health and Nutrition Congress, 2013, p. 63-74. FINK-GREMMELS, J. Mycotoxins: Their implications for human and animal health. Veterinary Quarterly, v.21, p.115-120, 1999. FOREMAN, J.H.; CONSTABLE, P.D.; WAGGONER, A.L.; LEVY, M.; EPPLEY, R.M.; SMITH, G.W.; TUMBLESON, M.E.; HASCHEK, W.M. Neurologic abnormalities and cerebrospinal fluid changes in horses administered fumonisin B1 intravenously. Journal of Veterinary Internal Medicine, v.18, p.223?230, 2004. GALTIER, P. Biotransformation and fate of mycotoxins. Journal of Toxicology-Toxin Reviews, v.18, p.295?312, 1999. GELDERBLOM, W.C.A.; JASKIEWICZ, K.; MARASAS, W.F.O.; THIEL, P.G.; HORAK, M.J.; VLEGGAAR, R.; KRIEK, N.P.J. Fumonisins?novel mycotoxins with cancer promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology, v.54, p.1806?1811, 1988. 19 GRATZ, S.; MYKKANEN, H.; OUWEHAND, A. C.; JUVONEN, R.; SALMINEN, S.; EL-NEZAMI, H. Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. Applied and Environmental Microbiology, v.70, p.6306?6308, 2004. GREGORI, R.; MERIGGI, P.; PIETRI, A.; FORMENTI, S.; BACCARINI, G.; BATTILANI, P. Dynamics of fungi and related mycotoxins during cereal storage in silo bags. Food Control, v.30, p.280-287, 2013. GRENIER, B.; OSWALD, I.P. Mycotoxin co-contamination of food and feed: Meta analysis of publications describing toxicological interactions. World Mycotoxin Journal, v.4, p.285?313, 2011. GUSILS, C.; BUJAZHA, M.; GONZ?LEZ, S. Preliminary studies to design a probiotic for use in swine feed. Interciencia, v. 27, n. 8, p. 409-413, 2002. HASKARD, C. A.; EL-NEZAMI, H. S.; KANKAANPAA, P. E.; SALMINEN, S.; AHOKAS, J. T. Surface binding of alfatoxin B1 by lactic acid bacteria. Applied and Environmental Microbiology, 67, 3086?3091, 2001. HASKARD, C.; BINNION, C.; AHOKAS, J. Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chemico-Biological Interactions, v.128, p.39?49, 2000. HE, J.; ZHOU, T.; YOUNG, J. C.; BOLLAND, G. J. Chemical and biological transformations of trichothecene mycotoxins in human and animal food chains: a review. Trends in Food and Science Technology, v.21, p.67?76, 2010. HERNANDEZ-MENDOZA, A.; GARCIA, H.S.; STEELE, J.L. Screening of Lactobacillus casei strains for their ability to bind aflatoxin B1. Food and Chemical Toxicology, v.47, p.1064-1068, 2009. HIROOKA, E. Y.; VIOTTI, N. M. A.; SOARES, L. M. V.; ALFIERI, A. L. Intoxica??o em equinos por micotoxinas produzidas por Fusarium moniliforme no norte do Paran?. Semina, v. 9, p.128-135, 1988. HIROOKA, E.Y.; VIOTTI, N.M.A.; MAROCHI, M.A.; ISHII, K.; UENO, Y. Leucoencefalomal?cia em equinos no norte do Paran?. Revista de Microbiologia, v. 21, p. 223-227, 1990. HOPMANS, H.C.; HAUCK, C.C.; HENDRICH, S.E.; MURPHY, P.A. Excretion of fumonisin B1-fructose adduct in rats. Journal of Agricultural and Food Chemistry, v.45, p.2618-2625, 1997. HUSSEIN, H.S.; BRASEL, J.M. Toxicity, metabolism and impact of mycotoxins on humans and animals. Toxicology, v. 167, n. 2, p. 101-134, 2001. HUWIG, A.; FREIMUND, S.; KAPPELI, O.; DUTLER, H. Mycotoxin detoxication of animal feed by different adsorbents. Toxicology Letters, v. 122, n. 2, p. 179- 188, 2001. JOUANY, J.P.; YIANNINKOURIS, A.; BERTIN, G. How yeast cell wall components can alleviate micotoxicosis in animal production and improve the safety of edible animal products. Journal of Animal and Feed Sciences, v. 14, suppl 1., p. 171- 191, 2005. KELLER, K.M.; QUEIROZ, B.D.; KELLER, L.A.M.; RIBEIRO, J.M.M.; CAVAGLIERI, L.R.; PEREYRA, M.L.G.; DALCERO, A.M.; ROSA, C.A.R. The mycobiota and toxicity of equine feeds. Veterinary Research Communications, v. 31, n. 8, p. 1037- 1045, 2007. 20 KELLERMAN, T. S.; MARASAS, W. F. O.; THIEL, P. G.; GELDERBLOM, W. C. A.; CAWOOD, M.; COETZER, A.W. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort Journal of Veterinary Research, v.57, n.4, p. 269-275, 1999. KIM, E.K.; SCOTT, P.M.; LAU, B.P. Hidden fumonisin in cornflakes. Food Additives and Contaminants, v.20, p.161-169, 2003. K?HLE, A.; SKOVGAARD, K.Y.; JESPERSEN, L. In vitro screening of probiotic properties of Saccharomyces cerevisiae var. boulardii and food borne Saccharomyces cerevisiae strains. International Journal of Food Microbiology, v. 101, n. 1, p. 29-39, 2004. KUIPER-GOODMAN, T. Food safety: mycotoxins and phycotoxins in perspective. In: Miraglia, M.; Van Egmond, H.; Brera, C.; Gilbert, J. (eds.). Mycotoxins and phycotoxins?developments in chemistry, toxicology and food safety. Oxford, United Kingdom, International Union of Pure and Applied Chemistry (IUPAC), 1998, p. 25-48. LAHTINEN, S. J.; HASKARD, C. A.; OUWEHANDZ, A. C.; SALMINENZ, S. J.; AHOKASY, J. T. Binding of aflatoxin B1 to cell wall components of Lactobacillus rhamnosus strain GG. Food Additives and Contaminants, v.21, p.158?164, 2004. LALLES, J.P.; LESSARD, M.; OSWALD, I.P.; DAVID, J.C. Consumption of fumonisin B1 for 9 days induces stress proteins along the gastrointestinal tract of pigs. Toxicon, v.55, p.244?249, 2010. LEE, Y., EL-NEZAMI, H., HASKARD, C., GRATZ, S., PUONG, K., SALMINEN, S. & MYKK?NEN, H. Kinetics of adsorption and desorption of aflatoxin B1 by viable and nonviable bacteria. Journal of Food Protection, v.66, n.3, p.426-430, 2003. LESSARD, M.; BOUDRY, G.; SEVE, B.; OSWALD, I.P.; LALLES, J.P. Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins. Journal of Nutrition, v.139, p.1303?1307, 2009. LIESENER, K.; CURTUI, V.; DIETRICH, R.; M?RTLBAUER, E.; USLEBER, E. Mycotoxins in horse feed. Mycotoxin Research, v. 26, p.23?30, 2010. LIMA, R.A.S.; SHIROTA, R.; BARROS, G.S.C. Estudo do complexo do agroneg?cio cavalo. 1 Ed. Piracicaba: ESALQ/USP, 2006, 250p. LINO, C.M.; SILVA, L.J.G.; PENA, A.S. Evaluation of fumonisins exposure: biomarkers. Revista Portuguesa de Ci?ncias Veterin?rias, v.102, p. 5-15, 2004. LOISEAU, N.; DEBRAUWER, L.; SAMBOU, T.; BOUHET, S.; MILLER, J.D.; MARTIN, P.G.; VIADERE, J.L.; PINTON, P.; PUEL, O.; PINEAU, T.; TULLIEZ, J.; GALTIER, P.; OSWALD, I.P. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage. Biochemical and Pharmacology, v.74, n.1, p.144-152, 2007. MALLMANN, C. A.; SANTURIO, J. M.; DILKIN, P. Leucoencefalomal?cia equina associada ? ingest?o de milho contaminado por fumonisina B1. Revista de Microbiologia, v. 30, n. 3, p. 249-252, 1999. MALLMANN, C.A.; SANTURIO, J.M.; ALMEIDA, C.A.A.; DILKIN, P. Fumonisin B1 levels in cereals and feeds from southern Brazil. Arquivos do Instituto Biol?gico, v.68, n.1, p. 41-45, 2001. MANSFIELD, M.A.; JONES, A.D., KULDAU, G.A. Contamination of fresh and ensiled maize by multiple Penicillium mycotoxins. Phytopathology, v.98, p.330-336, 2008. 21 MAPA - Minist?rio da Agricultura, Pecu?ria e Abastecimento. Proje??es do Agroneg?cio: Brasil 2012/2013 a 2022/2023. Assessoria de Gest?o Estrat?gica. Bras?lia, 2013, 96 p. MAPA - Minist?rio da Agricultura, Pecu?ria e Abastecimento. Instru??o Normativa N? 15, de 26 de maio de 2009. Dispon?vel em: http://extranet.agricultura.gov.br/sislegis/action/detalhaAto.do?method=consultarLegislacaoFederal. Acesso em 15 de abril de 2014. MARASAS, W.F.O.; KELLERMAN, T.S.; GELDERBLOM, W.C.A.; COETZER, J.A.;THIEL, P.G.; VAN DER LUGT, J.J. Leukoencephalomalacia in horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort Journal of Veterinary Research, v. 55, p.197-203, 1988. MARASAS, W.F.O.; RILEY, R.T.; HENDRICKS, K.A.; STEVENS, V.L.; SADLER, T.W.; GELINEAU-VAN WAES, J.; MISSMER, S.A.; CABRERA, J.; TORRES, O.; GELDERBLOM, W.C.A.; ALLEGOOD, J.; MART?NEZ, C.; MADDOX, J.; MILLER, J.D.; STARR, L.; SULLARDS, M.; ROMAN, A.V.; VOSS, K.A.; WANG, E.; MERRILL, A.H. Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin contaminated maize. Journal of Nutrition, v.134, p.711?716, 2004. MARTEAU, P.; MINEKUS, M.; HAVENNAR, R.; HUIS IN?T VELD, J.H.J. Survival of lactic acid bacterias in a dynamic model of the stomach and small intestine: validation and effects of bile. Journal of Dairy Science, v. 80, n. 6, p. 1031-1037, 1997. MAZIERO, M. T.; BERSOT, L.S. Micotoxinas em alimentos produzidos no Brasil. Revista Brasileira de Produtos Agroindustriais, v.12, n.1, p.89-99, 2010. MEIRELES, M. A.; CORR?A, B.; FISCHMAN, O.; GAMBALE, W.; PAULA, C. R.; CHACON-RECHE, N. O.; POZZI, C. R. Mycoflora of the toxic feeds associated with equine leucoencephalomalacia (ELEM) outbreaks in Brazil. Mycopathology, v. 127, p.183-188, 1994. M?NDEZ, M.C.; F. ; RIET-CORREA. Intoxica??es por Plantas e Micotoxinas. In: Riet-Corre,a F.; Schild, A.L.; Lemos, R.A.A.; Borges, J.R.J. (Eds). Doen?as dos Ruminantes e Equinos, v.2, p.99-222, 2007. MEYER, K.; MOHR, K.; BAUER, J.; HORN, P.; KOV?CS, M. Residue formation of fumonisin B1 in porcine tissues. Food Additives and Contaminants, v.20, n.7, p.639-647, 2003. MURPHY, P.A.; HENDRICH, S.; LANDGREN, C.; BRYANT, C.M. Food Mycotoxins: An Update. Journal of Food Science, v.71, n.5, p.51-65, 2006. NRC - NATIONAL RESEARCH COUNCIL. Nutrient requirements of horses. 6.ed. Rev. Washington, D.C.: National Academies Press, 2007, 341p. NEWMAN, K.E.; RAYMOND, S.L. Effects of mycotoxins in horses. In: Diaz, D.E. (Ed.) The Mycotoxin Blue Book. Nottingham University Press. 2005, p.57?76. PARK, J.W.; SCOTT, P.M.; LAU, B.P.; LEWIS, D.A. Analysis of heat-processed corn foods for fumonisins and bound fumonisins. Food Additives and Contaminants, v.21, p.1168-1178, 2004. 22 PATZAK, M.; DOSTALEK, P.; FOGARTY, R.V.; SAFARIK, I.; TOBIN, J.M. Development of magnetic biosorbents for metal uptake. Biotechnology Techniques, v. 11, n. 7, 483-487, 1997. PITT, J. I. Toxigenic fungi and mycotoxins. British Medical Bulletin, v.56, n.1, p.184-92, 2000. PIZZOLITTO R.P.; BUENO D.J.; ARMANDO M.R.; CAVAGLIERI L.; DALCERO A.M.; SALVANO M.A. Binding of aflatoxin B1 to lactic acid bacteria and Saccharomyces cerevisiae in vitro: a useful model to determine the most efficient microorganism. Intech Open Access Publisher, p.1-20, 2011. PIZZOLITTO, R.P.; SALVANO, M.A.; DALCERO, A.M.; Analysis of fumonisin B1 removal by microorganisms in co-ocurrence with aflatoxin B1 and the nature of the binding process. International Journal of Food Microbiology, v.4156, p.214-221, 2012. PRELUSKY, D.B.; MILLER, J.D.; TRENHOLM, H.L. Disposition of 14C-derived residues in tissues of pigs fed radiolabelled fumonisin B1. Food Additives and Contaminants, v.13, n.2, p.155-162, 1996. RAGSDAL, J.M.; B.M., DEBEY. Equine leucoencephalomalacia linked to contamined corn. Kansas University Agricultural Experiment Station and Cooperative Extension Service, v. 6, n. 2, p.1-6, 2003. RAMOS GIRONA, A.J.; ROSA, C.A.R.; CAVAGLIERI, L.R.; GUEDES, C.A. Legislaci?n e impacto econ?mico de las micotoxinas. In: RAMOS, A.J (Ed). Micotoxinas Y Micotoxicoses, 1 ed. AMV Editiones, 2011, Cap.18, -462p. RAYMOND, S.L.; SMITH, T.K.; SWAMY, H.V.L.N. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on feed intake, serum chemistry, and hematology of horses, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. Journal of Animal Science, v.81, p.2123?2130, 2003. REGO CHAVES, L. Doen?a de sintomatologia nervosa causada pela intoxica??o pelo milho. Revista Medicina Veterin?ria, v. 10, p. 199-217, 1950. RIET-CORREA, F.; MEIRELES, M. A.; SOARES, J. M.; MACHADO, J. J.; ZAMBRANO, A. F. Leucoencefalomal?cia associada ? ingest?o de milho mofado. Pesquisa Veterin?ria Brasileira, v. 2, p.27-30, 1982. RIET-CORREA, F.; TABOSA, I. M.; AZEVEDO, E. O.; MEDEIROS, R. M. T.; SIM?ES, S. V. D.; DANTAS, A. A.; ALVES, J. C.; NOBRE, V. M. T.; ATHAYLDE, A. C.; GOMES, A. A.; LIMA, E. F. Doen?as de ruminantes e equinos no semi-?rido da Para?ba. Semi-?rido em Foco, v.1, p.2-86, 2003. RIET-CORREA, G.; DUARTE, M. D.; CERQUEIRA, V. D.; RIET-CORREA, F. Leucoencephalomalacia in mules in Northern Brazil, In: PANTER, K. E.; WIERENGA, T. L.; PFISTER, J. A. Poisonous plants: global research and solutions. CABI Publishing, p. 256-262, 2007. RILEY, R.T.; PESTKA, J.; DIAZ, D.E. Mycotoxins: metabolism, mechanisms and biochemical markers. The mycotoxin blue book, p. 279-294, 2005. RODR?GUEZ-AMAYA, D.B.; SABINO, M. Mycotoxin research in Brazil: the last decade in review. Brazilian Journal of Microbiology, v.33, p.1-11, 2002. ROSS, P.F.; LEDET, A.E.; OWENS, D.L.; RICE, L.G.; NELSON, H.A.; OSWEILER, G.D.; WILSON, T.M. Experimental equine leukoencephalomalacia, toxic hepatosis, and 23 encephalopathy caused by corn naturally contaminated with fumonisins. Journal of Veterinary Diagnostic Investigation, v.5, n.1, p.69-74, 1993. ROSS, P.F.; RICE, L.G.; REAGOR, J.C.; OSWEILER, G.D.; WILSON, T.M.; NELSON, H.A.; OWENS, D.L.; PLATTNER, R.D.; HARLIN, K.A.; RICHARD, J.L.; COLVIN, B.M.; BANTON, M.I. Fumonisin B1 concentrations in feeds from 45 confirmed equine leukoencephalomalacia cases. Journal of Veterinary Diagnostic Investigation, v.3, p.238?241, 1991. SALLES-GOMES, T.L.; ALMEIDA, P.E.; MOREIRA, M.; CANOLA, J.C.; CANOLA, P.A.; SOUZA, H.A. Surto de leucoencefalomal?cia equina provocada por ra??o comercial com concentra??o de fumonisina inferior a 10 ppm. ARS Veterin?ria, v.19, n.3, p.267-271, 2003. SANTOS, C.E.P.; SOUTO, F.S.M.; SANTURIO, J.M.; MARQUES, L.C. Leucoencefalomal?cia em equ?deos da regi?o Leste de Mato Grosso. Acta Scientiae Veterinariae, v.41, p.1119-1124, 2013. SHEPHARD, G.S. Impact of mycotoxins on human health in developing countries. Food Additives & Contaminants, v.25, n.2, p.146?151, 2008. SHEPHARD, G.S.; P.W., SNIJMAN. Elimination and excretion of a single dose of a mycotoxin fumonisin B2 in a non-human primate. Food and Chemical Toxicology, v. 37, p.111-116, 1999. SHETTY, P.H.; HALD, B.Y; JESPERSEN, L. Surface binding of aflatoxin B1 by Saccharomyces cerevisiae strains with potential decontaminating abilities in indigenous fermented foods. International Journal of Food Microbiology, v. 113, n. 1, p. 41-46, 2007. SHETTY, P.H.; JESPERSEN, L. . Saccharomyces cerevisiae and lactic acid bacteria as potential mycotoxin decontaminating agents. Trends in Food Science and Technology, v.17, p.48?55, 2006. SINDIRA??ES - Sindicato Nacional da Ind?stria de Alimenta??o Animal. Boletim informativo do setor de alimenta??o animal/ maio 2014. Consultado em 14/05/2014 em: http://sindiracoes.org.br/wp-content/uploads/2014/05/boletim-informativo-do-setor_vs-portugues_site-08052014.pdf SMITH, G.W.; CONSTABLE, P.D.; FOREMAN, J.H.; EPPLEY, R.M.; WAGGONER, A.L.; TUMBLESON, M.E.; HASCHEK, W.M. Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses. American Journal of Veterinary Research, V.63, p.538?545, 2002. STOCKMANN-JUVALA, H.; SAVOLAINEN, K.,. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & Experimental Toxicology, v.27, p.799?809, 2010. STREIT, E.; SCHATZMAYR, G.; TASSIS, P.; TZIKA, E.; MARIN, D.; TARANU, I.; TABUC, C.; NICOLAU, A.; APRODU, I.; PUEL, O.; OSWALD, I.P. Current situation of mycotoxin contamination and co-occurrence in animal feed ? focus on Europe. Toxins, v.4, p.788-809, 2012. TELLER, R.S.; SCHMIDT, R.J.; WHITLOW, L.W.; KUNG, L.JR. Effect of physical damage to ears of corn before harvest and treatment with various additives on the concentration of mycotoxins, silage fermentation and aerobic stability of corn silage. Journal of Dairy Science, v.95, p.1428-1436, 2012. 24 THEUMER, M.G.; RUBINSTEIN, H.R. Interacciones de las micotoxinas. In: RAMOS, A.J. (ed). Mycotoxinas y micotoxicosis. 1ed. 2011, p.373-394. TRENHOLM, H.L.; FOSTER, B.C.; CHARMLEY, L.L.; THOMPSON, B.K.; HARTIN, K.E.; COPPOCK, R.W.; ALBASSAM, M.A. Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs. Canadian Journal of Animal Science, v.74, p.361?369, 1994. UNI?O EUROP?IA ? UE Directiva 2006/576/CE - Recomenda??o da Comiss?o de 17 de Agosto de 2006 sobre a presen?a de desoxinivalenol, zearalenona, ocratoxina A, toxinas T-2 e HT-2 e fumonisinas em produtos destinados ? alimenta??o animal. Jornal Oficial da Uni?o Europeia, L 229, p.7, 2006. UNI?O EUROP?IA ? UE Directiva 2002/32/CE do parlamento europeu e do Conselho de 7 de Maio de 2002 relativa ?s subst?ncias indesej?veis nos alimentos para animais, Jornal Oficial da Uni?o Europeia, L 140, p. 10, 30/5/2002. UNI?O EUROP?IA ? UE Directiva 2003/100/CE da Comiss?o de 31 de outubro de 2003 que altera o anexo I da Directiva 2002/32/CE do Parlamento Europeu e do Conselho relativa ?s subst?ncias indesej?veis nos alimentos para animais. Jornal Oficial da Uni?o Europeia, L 285, p. 33, 1/11/2003. VACLAVIKOVA, M.; MALACHOVA, A.; VEPRIKOVA, Z.; DZUMAN, Z.; ZACHARIASOVA, M.; HAJSLOVA, J. ?Emerging? mycotoxins in cereals processing chains: changes of enniatins during beer and bread making. Food Chemistry, v.136, p.170-757, 2013. VENDL, O.; BERTHILLER, F.; CREWS, C.; KRSKA, R. Simultaneous determination of deoxynivalenol, zearalenone and their major masked metabolites in cereal-based food by LC675 MS-MS. Analytical and Bioanalytical Chemistry, v.395, p.1347?1354, 2009. VOSS, K.A.; RILEY, R.T.; NORRED, W.P.; BACON, C.W.; MEREDITH, F.I.; HOWARD, P.C.; PLATTNER, R.D.; COLLINS, T.F.X.; HANSEN, D.K.; PORTER, J.K. An overview of rodent toxicities: Liver, and kidney effects of fumonisins and Fusarium moniliforme. Environmental Health Perspectives, v.109, p.259?266, 2001. VOSS, K.A.; SMITH, G.W.; HASCHEK, W.M. Fumonisins: toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology, v.137, p.299?325, 2007. WANG, E.; ROSS, P.; WILSON, T.; RILEY, R.; MERRILI, A. Increases in Serum Shingosine and Shinganine and Decreases in Complex Sphingolipids in Ponies Given Feed Containing Fumonisins, Mycotoxins Produced by Fusarium moniliforme. Journal of Nutrition, v. 122, p.1706 ? 1716, 1992 WEBSTER, J.; WEBER, R. Introduction to Fungi, 3 ed. Cambridge University Press, 2007, 867p. WEESE, J.A. Review of probiotics: Are they really ?Functional Foods??. Proceedings of the American Association of Equine Practitioners (AAEP, v. 47, p. 27-31, 2001. WILSON, T.M.; ROSS, P.F.; OWENS, D.L.; RICE, L.G.; JENKINS, S.J.; NELSON H.A. Experimental production of ELEM, a study to determine the minimum toxic dose in ponies. Mycopathology, v.117, p.115-120, 1992. WOLOSHUK, C.P.; SHIM, W.B. Aflatoxins, fumonisins and trichothecenes: a convergence of knowledge. FEMS Microbiology Letters, v.37, p.94-109, 2013. 25 XAVIER, J.G.; BRUNNER, C.H.M.; SAKAMOTO, M.; CORREA, B.; FERNANDES, W. R.; DIAS, J. L. C. Equine leucoencephalomalacia: report of five cases. Brazilian Journal of Veterinary Research and Animal Science, v. 28, p.185-189, 1991. YIANNIKOURIS, A.; FRAN?OIS, J.; POUGHON, L.; DUSSAP, C.G.; JEMINET, G.; JOUANY, J.P. Influence of pH on complexing of model beta-d-glucans with zearalenone. Journal of Food Protection, v.67, n.12, p.2741-6, 2004a. YIANNIKOURIS, A.; FRAN?OIS, J.; POUGHON, L.; DUSSAP, C.G.; BERTIN, G.; JEMINET, G.; JOUANY, J.P. Alkali extraction of ?-D-glucans from Saccharomyces cerevisiae cell wall and study of their adsorptive properties towards Zearalenone. Journal of Agricultural and Food Chemistry, v. 52, n. 11, p. 3666-3673, 2004b. YIANNIKOURIS, A.; FRANCOIS, J.; POUGHON, L.; DUSSAP, C.G.; JEMINET, G.; JOUANY, J.P. Adsortion of zearalenone by beta-D-glucans in the Saccharomyces cerevisiae cell wall. Journal of Food Protection, v. 67, n. 6, p. 1195-1200, 2004c. YIANNIKOURIS, A.; JOUANY, J.P. Mycotoxins in feeds and their fate in animals: a review. Animal Research, v.51, p.81-99, 2002. YIANNIKOURIS, A.; POUGHON, L.; CAMELEYRE, X.; DUSSAP, C.G.; FRANCOIS, J.; BERTIN, G.; JOUANY, J.P. A novel technique to evaluate interactions between Saccharomyces cerevisiae cell wall and mycotoxins: application to zearalenone. Biotechnology Letters, v. 25, n. 10, p. 783- 789, 2003. YIN, J.J.; SMITH, M.J.; EPPLEY, R.M.; PAGE, S.W.; SPHON, J.A. Effects of fumonisin B1 on lipid peroxidation in membranes. Biochimica et Biophysica Acta, v.1371, p.134-142, 1998. ZACHARIASOVA. M.; DZUMAN, Z.; VEPRIKOVA, Z.; HAJKOVA, K.; JIRU, M.; VACLAVIKOVA, M.; POSPICHALOVA, M.; FLORIAN, M.; HAJSLOVA, J. Occurrence of multiple mycotoxins in European feedingstuffs, assessment of dietary intake by farm animals. Animal Feed Science and Technology, v.193, p. 124-140, 2014. ZINEDINE, A.; SORIANO, J. M.; MOLT?, J. C.; MA?ES, J. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food and Chemical Toxicology, v.45, n.1, p.1-18, 2007. 6 REFER?NCIAS BIBLIOGR?FICAS ARMANDO, M.R.; DOGI, C.A.; PIZZOLITTO, R.P.; ESCOBAR, F. PEIRANO, M.S.; SALVANO, M.A. SABINI, L.I.; COMBINA, M.; DALCERO, A.M.; CAVAGLIERI, L.R. Saccharomyces cerevisiae strains from animal environment with in vitro aflatoxin B1 binding ability and anti-pathogenic bacterial influence. World Mycotoxin Journal, v. 4, n. 1, p. 59-68, 2011. 37 ARMANDO, M.R.; GALVAGNO, M.A.; DOGI, C.A.; CERRUTTI, P.; DALCERO, A.M.; CAVAGLIERI, L.R. Statistical optimization of culture conditions for biomass production of probiotic gut-borne Saccharomyces cerevisiae strain able to reduce fumonisin B1. Journal of Applied Microbiology,
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Fumonisina B1 em alimentos para eq?inos: intera??es em sistemas de digest?o in vitro com Saccharomyces cerevisiae

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