Abarema cochliacarpos extract decreases the inflammatory process and skeletal muscle injury induced by bothrops leucurus venom

Snakebites are a public health problem, especially in tropical countries.However, treatment with antivenomhas limited effectiveness against venoms’ local effects. Here, we investigated the ability of Abarema cochliacarpos hydroethanolic extract (EAc) to protect mice against injection of Bothrops leu...

Full description

Access type:openAccess
Publication Date:2014
Main Author: Dias, Antônio Santos
Other Authors: Oliveira, Jeison Saturnino de, Santos, Daiana do Carmo, Guimarães, Adriana Gibara, Tomaz, Marcelo Amorim, Machado, Marcos Monteiro, Estevam, Charles dos Santos, Lucca Júnior, Waldecy de, Maria, Durvanei Augusto, Melo, Paulo de Assis, Araújo, Adriano Antunes de Souza, Santos, Márcio Roberto Viana dos, Almeida, Jackson Roberto Guedes da Silva, Oliveira, Rita de Cássia Meneses, Oliveira, Aldeidia Pereira de, Quintans-Júnior, Lucindo José
Document type: Article
Language:eng
Published: Hindawi Publishing Corporation
Portuguese subjects:
Online Access:https://ri.ufs.br/handle/riufs/1414
Citation:OLIVEIRA, J. S. et. al. Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom. BioMed Research International, v. 2014, 2014. Disponível em: <http://dx.doi.org/10.1155/2014/820761>. Acesso em: 29 jan. 2015.
Portuguese abstract:Snakebites are a public health problem, especially in tropical countries.However, treatment with antivenomhas limited effectiveness against venoms’ local effects. Here, we investigated the ability of Abarema cochliacarpos hydroethanolic extract (EAc) to protect mice against injection of Bothrops leucurus venom. Swiss mice received perimuscular venom injection and were subsequently treated orally with EAc in different doses. Treatment with EAc 100, 200, and 400mg/kg reduced the edema induced by B. leucurus in 1%, 13%, and 39%, respectively. Although lower doses showed no antihypernociceptive effect in the Von Frey test, the higher dose significantly reduced hyperalgesia induced by the venom. Antimyotoxic activity of EAc was also observed by microscopy assessment, with treated muscles presenting preserved structures, decreased edema, and inflammatory infiltrate as compared to untreated ones. Finally, on the rotarod test, the treated mice showed better motor function, once muscle fibers were preserved and there were less edema and pain. Treated mice could stand four times more time on the rotating rod than untreated ones. Our results have shown that EAc presented relevant activities against injection of B. leucurus venom in mice, suggesting that it can be considered as an adjuvant in the treatment of envenomation.