Investigation of protective effects of erythrina velutina extract against MMS induced damages in the root meristem cells of allium cepa

Erythrina velutina Willd., Fabaceae, is a medicinal plant that can be found in the tropics and subtropics, including in the semi-arid northeastern Brazil. It is commonly used in folk medicine to treat anxiety, agitation and insomnia. E. velutina has been known to present analgesic, anti-infl ammator...

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Access type:openAccess
Publication Date:2013
Main Author: Dias, Antônio Santos
Other Authors: Silva, Déborah Soares Bispo Santos, Barboza, Benhur, Garcia, Anuska Conde Fagundes Soares, Oliveira, Betejane de, Estevam, Charles dos Santos, Araújo Neto, Vitor, Santos, André Luiz Lima Menezes dos, Scher, Ricardo, Pantaleao, Silmara de Moraes
Document type: Article
Language:eng
Published: Sociedade Brasileira de Farmacognosia
Portuguese subjects:
Online Access:https://ri.ufs.br/handle/riufs/1415
Citation:SILVA, D. S. B. S. et. al. Investigation of protective effects of erythrina velutina extract against MMS induced damages in the root meristem cells of allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 2, mar./abr. 2013. Disponível em: <http://www.scielo.br/scielo.php?pid=S0102-695X2013000200011&script=sci_arttext>. Acesso em: 29 jan. 2015.
Portuguese abstract:Erythrina velutina Willd., Fabaceae, is a medicinal plant that can be found in the tropics and subtropics, including in the semi-arid northeastern Brazil. It is commonly used in folk medicine to treat anxiety, agitation and insomnia. E. velutina has been known to present analgesic, anti-infl ammatory and antibacterial activities, however, it is unknown if this plant present a protective effect on DNA. We assessed the antigenotoxic effect of E. velutina against the genotoxic effects induced by MMS in the root meristem cells of Allium cepa. Three concentrations of the aqueous extract (100, 200 and 400 mg/L) of this medicinal plant were used in three different types of treatment (pre-, post- and simultaneous). The effects of the extracts on the root meristem cells of A. cepa were analyzed at both macroscopic and microscopic levels. Protective effects were observed at higher concentrations in pre-treatment and in simultaneous treatment. The results suggest that E. velutina may present antigenotoxic properties and demonstrate its chemopreventive potential.