Sildenafil citrate on retrobulbar and retinal circulation of rabbits

Detalhes bibliográficos
Autor(a) principal: Amaral,Andréia Vitor Couto do
Data de Publicação: 2014
Outros Autores: Silva,Germana Alegro da, Costa,Ana Paula Araújo, Coelho,Cássia Maria Molinaro, Renzo,Roberta, Laus,José Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000801431
Resumo: The effects of sildenafil on retrobulbar and retinal circulation were studied in 18 adult male, albino, homozygous rabbits, of the New Zealand White breed, randomly divided into 3 groups of 6 animals, for drug treatment at a dose of 3.5mg kg-1 every 24 hours, for 7, 15 and 30 days. Nine animals used for control were treated with saline solution at 0.9%. It was evaluated intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (PPO), B-mode ultrasonography and fluorescein angiography before and at the end of treatments. A slight decrease in results of IOP, MAP and PPO after treatment with sildenafil was evident, however, there was no statistical significance. It was observed significant increased diameter of the ophthalmic artery after 7 and 30 days of treatment and decreased mean arterial pressure after 7, 15 and 30 days of treatment, with no statistical difference. On fluorescein angiography, it was observed that the arterial, arteriovenous and venous stages initiated more rapidly in animals after treatment, with significant difference on the arteriovenous stage at the 7th and 15th days. It was possible to admit that the sildenafil citrate improves blood circulation in the retina of rabbits, by increasing the speed of blood flow and decreasing the perfusion pressure.
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spelling Sildenafil citrate on retrobulbar and retinal circulation of rabbitsrabbitssildenafil citrateretrobulbar circulationretinal circulationultrasonographyfluorescein angiographyThe effects of sildenafil on retrobulbar and retinal circulation were studied in 18 adult male, albino, homozygous rabbits, of the New Zealand White breed, randomly divided into 3 groups of 6 animals, for drug treatment at a dose of 3.5mg kg-1 every 24 hours, for 7, 15 and 30 days. Nine animals used for control were treated with saline solution at 0.9%. It was evaluated intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (PPO), B-mode ultrasonography and fluorescein angiography before and at the end of treatments. A slight decrease in results of IOP, MAP and PPO after treatment with sildenafil was evident, however, there was no statistical significance. It was observed significant increased diameter of the ophthalmic artery after 7 and 30 days of treatment and decreased mean arterial pressure after 7, 15 and 30 days of treatment, with no statistical difference. On fluorescein angiography, it was observed that the arterial, arteriovenous and venous stages initiated more rapidly in animals after treatment, with significant difference on the arteriovenous stage at the 7th and 15th days. It was possible to admit that the sildenafil citrate improves blood circulation in the retina of rabbits, by increasing the speed of blood flow and decreasing the perfusion pressure.Universidade Federal de Santa Maria2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000801431Ciência Rural v.44 n.8 2014reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20130981info:eu-repo/semantics/openAccessAmaral,Andréia Vitor Couto doSilva,Germana Alegro daCosta,Ana Paula AraújoCoelho,Cássia Maria MolinaroRenzo,RobertaLaus,José Luizeng2014-11-24T00:00:00ZRevista
dc.title.none.fl_str_mv Sildenafil citrate on retrobulbar and retinal circulation of rabbits
title Sildenafil citrate on retrobulbar and retinal circulation of rabbits
spellingShingle Sildenafil citrate on retrobulbar and retinal circulation of rabbits
Amaral,Andréia Vitor Couto do
rabbits
sildenafil citrate
retrobulbar circulation
retinal circulation
ultrasonography
fluorescein angiography
title_short Sildenafil citrate on retrobulbar and retinal circulation of rabbits
title_full Sildenafil citrate on retrobulbar and retinal circulation of rabbits
title_fullStr Sildenafil citrate on retrobulbar and retinal circulation of rabbits
title_full_unstemmed Sildenafil citrate on retrobulbar and retinal circulation of rabbits
title_sort Sildenafil citrate on retrobulbar and retinal circulation of rabbits
author Amaral,Andréia Vitor Couto do
author_facet Amaral,Andréia Vitor Couto do
Silva,Germana Alegro da
Costa,Ana Paula Araújo
Coelho,Cássia Maria Molinaro
Renzo,Roberta
Laus,José Luiz
author_role author
author2 Silva,Germana Alegro da
Costa,Ana Paula Araújo
Coelho,Cássia Maria Molinaro
Renzo,Roberta
Laus,José Luiz
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Amaral,Andréia Vitor Couto do
Silva,Germana Alegro da
Costa,Ana Paula Araújo
Coelho,Cássia Maria Molinaro
Renzo,Roberta
Laus,José Luiz
dc.subject.por.fl_str_mv rabbits
sildenafil citrate
retrobulbar circulation
retinal circulation
ultrasonography
fluorescein angiography
topic rabbits
sildenafil citrate
retrobulbar circulation
retinal circulation
ultrasonography
fluorescein angiography
description The effects of sildenafil on retrobulbar and retinal circulation were studied in 18 adult male, albino, homozygous rabbits, of the New Zealand White breed, randomly divided into 3 groups of 6 animals, for drug treatment at a dose of 3.5mg kg-1 every 24 hours, for 7, 15 and 30 days. Nine animals used for control were treated with saline solution at 0.9%. It was evaluated intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (PPO), B-mode ultrasonography and fluorescein angiography before and at the end of treatments. A slight decrease in results of IOP, MAP and PPO after treatment with sildenafil was evident, however, there was no statistical significance. It was observed significant increased diameter of the ophthalmic artery after 7 and 30 days of treatment and decreased mean arterial pressure after 7, 15 and 30 days of treatment, with no statistical difference. On fluorescein angiography, it was observed that the arterial, arteriovenous and venous stages initiated more rapidly in animals after treatment, with significant difference on the arteriovenous stage at the 7th and 15th days. It was possible to admit that the sildenafil citrate improves blood circulation in the retina of rabbits, by increasing the speed of blood flow and decreasing the perfusion pressure.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000801431
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000801431
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20130981
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.44 n.8 2014
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
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