Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy
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Publication Date: | 2016 |
Other Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Source: | Ciência Rural |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000901642 |
Summary: | ABSTRACT: Cardiotoxicity induced by doroxubicin generates systolic disfunction and myocardial remodeling with presence of myofibroblasts. These cells are thought to be attracted to the injured heart to avoid the development of congestive heart failure. The objective of this study was to evaluate the systolic dysfunction generated by doxorubicin through Doppler echocardiography, and its correlation with the presence of myofibroblasts in the myocardium. Twenty-five New Zealand White rabbits were divided into two groups (control, and treated with doxorubicin). The drug was administered for six weeks; Doppler echocardiography was performed before the first, and after the last administration of doxorubicin. Immuno detection of myofibroblasts was performed by immunohistochemistry. The treated group exhibited significant reduction in systolic function as assessed by Doppler echocardiography, and increased frequency of myofibroblasts, which were present in similar amounts in the left ventricle, interventricular septum, and right ventricle. There was a significant negative correlation between number of myofibroblasts in the interventricular septum and in the left ventricle with systolic function indices, which reveals that the higher the number of fibroblasts, the worst systolic function is in rabbits treated with doxorubicin. Increase in myofibroblast numbers was not sufficient to preserve systolic function. |
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Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathyα-SMAdoxorubicinDoppler echocardiographyrabbitsABSTRACT: Cardiotoxicity induced by doroxubicin generates systolic disfunction and myocardial remodeling with presence of myofibroblasts. These cells are thought to be attracted to the injured heart to avoid the development of congestive heart failure. The objective of this study was to evaluate the systolic dysfunction generated by doxorubicin through Doppler echocardiography, and its correlation with the presence of myofibroblasts in the myocardium. Twenty-five New Zealand White rabbits were divided into two groups (control, and treated with doxorubicin). The drug was administered for six weeks; Doppler echocardiography was performed before the first, and after the last administration of doxorubicin. Immuno detection of myofibroblasts was performed by immunohistochemistry. The treated group exhibited significant reduction in systolic function as assessed by Doppler echocardiography, and increased frequency of myofibroblasts, which were present in similar amounts in the left ventricle, interventricular septum, and right ventricle. There was a significant negative correlation between number of myofibroblasts in the interventricular septum and in the left ventricle with systolic function indices, which reveals that the higher the number of fibroblasts, the worst systolic function is in rabbits treated with doxorubicin. Increase in myofibroblast numbers was not sufficient to preserve systolic function.Universidade Federal de Santa Maria2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000901642Ciência Rural v.46 n.9 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20151062info:eu-repo/semantics/openAccessGava,Fábio NelsonSilva,Sheila Nogueira Saraiva daRosa,Fernando AzadinhoOrtiz,Edna Mireya GómezRodrigues,Bruno CristianBandarra,Márcio de BarrosVasconcelos,Rosemeri de OliveiraCamacho,Aparecido Antonioeng2016-08-12T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
title |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
spellingShingle |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy Gava,Fábio Nelson α-SMA doxorubicin Doppler echocardiography rabbits |
title_short |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
title_full |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
title_fullStr |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
title_full_unstemmed |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
title_sort |
Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy |
author |
Gava,Fábio Nelson |
author_facet |
Gava,Fábio Nelson Silva,Sheila Nogueira Saraiva da Rosa,Fernando Azadinho Ortiz,Edna Mireya Gómez Rodrigues,Bruno Cristian Bandarra,Márcio de Barros Vasconcelos,Rosemeri de Oliveira Camacho,Aparecido Antonio |
author_role |
author |
author2 |
Silva,Sheila Nogueira Saraiva da Rosa,Fernando Azadinho Ortiz,Edna Mireya Gómez Rodrigues,Bruno Cristian Bandarra,Márcio de Barros Vasconcelos,Rosemeri de Oliveira Camacho,Aparecido Antonio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Gava,Fábio Nelson Silva,Sheila Nogueira Saraiva da Rosa,Fernando Azadinho Ortiz,Edna Mireya Gómez Rodrigues,Bruno Cristian Bandarra,Márcio de Barros Vasconcelos,Rosemeri de Oliveira Camacho,Aparecido Antonio |
dc.subject.por.fl_str_mv |
α-SMA doxorubicin Doppler echocardiography rabbits |
topic |
α-SMA doxorubicin Doppler echocardiography rabbits |
description |
ABSTRACT: Cardiotoxicity induced by doroxubicin generates systolic disfunction and myocardial remodeling with presence of myofibroblasts. These cells are thought to be attracted to the injured heart to avoid the development of congestive heart failure. The objective of this study was to evaluate the systolic dysfunction generated by doxorubicin through Doppler echocardiography, and its correlation with the presence of myofibroblasts in the myocardium. Twenty-five New Zealand White rabbits were divided into two groups (control, and treated with doxorubicin). The drug was administered for six weeks; Doppler echocardiography was performed before the first, and after the last administration of doxorubicin. Immuno detection of myofibroblasts was performed by immunohistochemistry. The treated group exhibited significant reduction in systolic function as assessed by Doppler echocardiography, and increased frequency of myofibroblasts, which were present in similar amounts in the left ventricle, interventricular septum, and right ventricle. There was a significant negative correlation between number of myofibroblasts in the interventricular septum and in the left ventricle with systolic function indices, which reveals that the higher the number of fibroblasts, the worst systolic function is in rabbits treated with doxorubicin. Increase in myofibroblast numbers was not sufficient to preserve systolic function. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000901642 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000901642 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20151062 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.46 n.9 2016 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140549800034304 |