Lifetime psychopathology among the offspring of Bipolar I parents
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/6263 http://dx.doi.org/10.1590/S1807-59322011000500003 |
Resumo: | BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
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Zappitelli, Marcelo Cardoso [UNIFESP]Bordin, Isabel Altenfelder Santos [UNIFESP]Hatch, John P.Caetano, Sheila Cavalcante [UNIFESP]Zunta-Soares, GiovanaOlvera, Rene L.Soares, Jair C.Universidade Federal de São Paulo (UNIFESP)The University of Texas Health Science Center Departments of Psychiatry and OrthodonticsUniversidade de São Paulo (USP)University of Texas Health Science CenterThe University of Texas Health Science Center Department of Psychiatry2015-06-14T13:42:52Z2015-06-14T13:42:52Z2011-01-01Clinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 725-730, 2011.1807-5932http://repositorio.unifesp.br/handle/11600/6263http://dx.doi.org/10.1590/S1807-59322011000500003S1807-59322011000500003.pdfS1807-5932201100050000310.1590/S1807-59322011000500003WOS:000293122900003BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)NARSADKrus Endowed Chair in Psychiatry UTHSCSAFederal University of São Paulo Department of PsychiatryThe University of Texas Health Science Center Departments of Psychiatry and OrthodonticsUniversidade de São Paulo Faculdade de Medicina Department of PsychiatryUniversity of Texas Health Science CenterThe University of Texas Health Science Center Department of PsychiatryUNIFESP, Department of PsychiatryNARSAD: MH 69774NARSAD: RR 20571NARSAD: MH068280SciELO725-730engFaculdade de Medicina / USPClinicsBipolar DisorderOffspringPsychopathologyChildAdolescentLifetime psychopathology among the offspring of Bipolar I parentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1807-59322011000500003.pdfapplication/pdf172466${dspace.ui.url}/bitstream/11600/6263/1/S1807-59322011000500003.pdf27c08bb44fe0f4ef93349d13d73fb506MD51open accessTEXTS1807-59322011000500003.pdf.txtS1807-59322011000500003.pdf.txtExtracted texttext/plain35907${dspace.ui.url}/bitstream/11600/6263/2/S1807-59322011000500003.pdf.txt919a7065bcfc322faacf2d16bdc9f7bbMD52open access11600/62632021-10-05 11:34:38.052open accessoai:repositorio.unifesp.br:11600/6263Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:15:26.736341Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Lifetime psychopathology among the offspring of Bipolar I parents |
title |
Lifetime psychopathology among the offspring of Bipolar I parents |
spellingShingle |
Lifetime psychopathology among the offspring of Bipolar I parents Zappitelli, Marcelo Cardoso [UNIFESP] Bipolar Disorder Offspring Psychopathology Child Adolescent |
title_short |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_full |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_fullStr |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_full_unstemmed |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_sort |
Lifetime psychopathology among the offspring of Bipolar I parents |
author |
Zappitelli, Marcelo Cardoso [UNIFESP] |
author_facet |
Zappitelli, Marcelo Cardoso [UNIFESP] Bordin, Isabel Altenfelder Santos [UNIFESP] Hatch, John P. Caetano, Sheila Cavalcante [UNIFESP] Zunta-Soares, Giovana Olvera, Rene L. Soares, Jair C. |
author_role |
author |
author2 |
Bordin, Isabel Altenfelder Santos [UNIFESP] Hatch, John P. Caetano, Sheila Cavalcante [UNIFESP] Zunta-Soares, Giovana Olvera, Rene L. Soares, Jair C. |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) The University of Texas Health Science Center Departments of Psychiatry and Orthodontics Universidade de São Paulo (USP) University of Texas Health Science Center The University of Texas Health Science Center Department of Psychiatry |
dc.contributor.author.fl_str_mv |
Zappitelli, Marcelo Cardoso [UNIFESP] Bordin, Isabel Altenfelder Santos [UNIFESP] Hatch, John P. Caetano, Sheila Cavalcante [UNIFESP] Zunta-Soares, Giovana Olvera, Rene L. Soares, Jair C. |
dc.subject.eng.fl_str_mv |
Bipolar Disorder Offspring Psychopathology Child Adolescent |
topic |
Bipolar Disorder Offspring Psychopathology Child Adolescent |
description |
BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
publishDate |
2011 |
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2011-01-01 |
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2015-06-14T13:42:52Z |
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2015-06-14T13:42:52Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 725-730, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/6263 http://dx.doi.org/10.1590/S1807-59322011000500003 |
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1807-5932 |
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S1807-59322011000500003.pdf |
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S1807-59322011000500003 |
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10.1590/S1807-59322011000500003 |
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WOS:000293122900003 |
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Clinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 725-730, 2011. 1807-5932 S1807-59322011000500003.pdf S1807-59322011000500003 10.1590/S1807-59322011000500003 WOS:000293122900003 |
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http://repositorio.unifesp.br/handle/11600/6263 http://dx.doi.org/10.1590/S1807-59322011000500003 |
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Faculdade de Medicina / USP |
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Faculdade de Medicina / USP |
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