Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma

Detalhes bibliográficos
Autor(a) principal: Marback, E. Ferrari
Data de Publicação: 2003
Outros Autores: Arias, V. E. A., Paranhos Junior, Augusto, Soares, F. A., Murphree, A. L., Erwenne, C. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8537
Resumo: Texto completo: acesso restrito. p. 1224-1228
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spelling Marback, E. FerrariArias, V. E. A.Paranhos Junior, AugustoSoares, F. A.Murphree, A. L.Erwenne, C. M.Marback, E. FerrariArias, V. E. A.Paranhos Junior, AugustoSoares, F. A.Murphree, A. L.Erwenne, C. M.2013-02-19T16:24:19Z20030007-1161http://www.repositorio.ufba.br/ri/handle/ri/8537v. 87, n. 10Texto completo: acesso restrito. p. 1224-1228Methods: This was a retrospective, non-randomised comparative clinicopathological study. The histopathology from 24 cases of Reese-Ellsworth (RE) group V unilateral retinoblastoma treated by enucleation alone was reviewed. Group I consisted of five patients (four RE group Vb and one group Va) who developed disseminated disease at a mean of 10.4 months after enucleation. The remaining 19 patients constitute group II (18 RE group Vb and 1 group Va), none of whom had developed metastatic disease with a mean follow up of 54 months. None of the 24 patients had evidence of extraocular disease at enucleation. The surgical specimens from patients with unilateral retinoblastoma treated by enucleation at Hospital do Cancer AC Camargo between January 1992 and December 1995 were identified, reviewed and the clinical data recorded. Two subsequent histological sections were prepared. One stained with haematoxylin and eosin for assessment of choroidal and optic nerve invasion, and the other for immunoreaction with an endothelium specific marker (antibody anti-CD 34).The main outcome measures were choroidal and/or optic nerve invasion and quantification of the tumour’s relative vascular area (TRVA) obtained by Chalkley countingResults: Choroidal invasion was present in three eyes of group I (all massive) and six eyes of group II (two focal and four massive). Optic nerve invasion was found in two eyes of group I (all post-laminar) and four eyes of group II (three prelaminar and one post-laminar). There was no statistical difference regarding choroidal or optic nerve between the two groups. The TRVA was the only independent variable found to predict disease dissemination (p = 0.008 by Cox analysis). A TRVA equal to or greater than 3.9% had 100% sensitivity and 79% specificity in predicting disease dissemination. Conclusions: Quantification of angiogenesis, through measurement of the TRVA, can help to identify patients with retinoblastoma at high risk for disease dissemination after enucleation.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2013-02-15T13:48:25Z No. of bitstreams: 1 1224.full.pdf: 200825 bytes, checksum: 8f75a0cb57b38e2ca933a4b9cf425acf (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-19T16:24:19Z (GMT) No. of bitstreams: 1 1224.full.pdf: 200825 bytes, checksum: 8f75a0cb57b38e2ca933a4b9cf425acf (MD5)Made available in DSpace on 2013-02-19T16:24:19Z (GMT). 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dc.title.pt_BR.fl_str_mv Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
dc.title.alternative.pt_BR.fl_str_mv British Journal of Ophthalmology
title Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
spellingShingle Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
Marback, E. Ferrari
title_short Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
title_full Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
title_fullStr Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
title_full_unstemmed Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
title_sort Tumour angiogenesis as a prognostic factor for disease dissemination in retinoblastoma
author Marback, E. Ferrari
author_facet Marback, E. Ferrari
Arias, V. E. A.
Paranhos Junior, Augusto
Soares, F. A.
Murphree, A. L.
Erwenne, C. M.
author_role author
author2 Arias, V. E. A.
Paranhos Junior, Augusto
Soares, F. A.
Murphree, A. L.
Erwenne, C. M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marback, E. Ferrari
Arias, V. E. A.
Paranhos Junior, Augusto
Soares, F. A.
Murphree, A. L.
Erwenne, C. M.
Marback, E. Ferrari
Arias, V. E. A.
Paranhos Junior, Augusto
Soares, F. A.
Murphree, A. L.
Erwenne, C. M.
description Texto completo: acesso restrito. p. 1224-1228
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2013-02-19T16:24:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8537
dc.identifier.issn.none.fl_str_mv 0007-1161
dc.identifier.number.pt_BR.fl_str_mv v. 87, n. 10
identifier_str_mv 0007-1161
v. 87, n. 10
url http://www.repositorio.ufba.br/ri/handle/ri/8537
dc.language.iso.fl_str_mv eng
language eng
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