Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/31337 https://dx.doi.org/10.1177/1470320309102317 |
Resumo: | Introduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I (AT(1))-receptor A1166C polymorphisms.Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer.Results. the frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2) ); and for AT(1)-receptor were: AA, AC and CC (in %; cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi(2)). the results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls.Conclusions. the ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. the ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible targer for developing genetic markers for breast cancer. |
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Corrêa, Silvana Aparecida Alves [UNIFESP]Noronha, Samuel Marcos Ribeiro de [UNIFESP]Nogueira-de-Souza, Naiara Corrêa [UNIFESP]Carvalho, Cristina Valletta de [UNIFESP]Costa, Ana Maria Massad [UNIFESP]Linhares, Jose Juvenal [UNIFESP]Gomes, Mariano Tamura Vieira [UNIFESP]Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T13:52:18Z2016-01-24T13:52:18Z2009-03-01Journal of the Renin-angiotensin-aldosterone System. London: Sage Publications Ltd, v. 10, n. 1, p. 51-58, 2009.1470-3203https://repositorio.unifesp.br/handle/11600/31337https://dx.doi.org/10.1177/147032030910231710.1177/1470320309102317WOS:000265789800008Introduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I (AT(1))-receptor A1166C polymorphisms.Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer.Results. the frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2) ); and for AT(1)-receptor were: AA, AC and CC (in %; cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi(2)). the results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls.Conclusions. the ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. the ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible targer for developing genetic markers for breast cancer.Universidade Federal de São Paulo, Mol Gynaecol Lab, Dept Gynaecol, BR-04039032 São Paulo, BrazilUniversidade Federal de São Paulo, Mol Gynaecol Lab, Dept Gynaecol, BR-04039032 São Paulo, BrazilWeb of Science51-58engSage Publications LtdJournal of the Renin-angiotensin-aldosterone Systemhttp://www.uk.sagepub.com/aboutus/openaccess.htminfo:eu-repo/semantics/openAccessAngiotensin-converting enzymeAngiotensin II type 1 receptorBreast cancerGenotypingPolymorphismsAssociation between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/313372022-12-13 17:46:15.412metadata only accessoai:repositorio.unifesp.br:11600/31337Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:42:58.451406Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
title |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
spellingShingle |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women Corrêa, Silvana Aparecida Alves [UNIFESP] Angiotensin-converting enzyme Angiotensin II type 1 receptor Breast cancer Genotyping Polymorphisms |
title_short |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
title_full |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
title_fullStr |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
title_full_unstemmed |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
title_sort |
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women |
author |
Corrêa, Silvana Aparecida Alves [UNIFESP] |
author_facet |
Corrêa, Silvana Aparecida Alves [UNIFESP] Noronha, Samuel Marcos Ribeiro de [UNIFESP] Nogueira-de-Souza, Naiara Corrêa [UNIFESP] Carvalho, Cristina Valletta de [UNIFESP] Costa, Ana Maria Massad [UNIFESP] Linhares, Jose Juvenal [UNIFESP] Gomes, Mariano Tamura Vieira [UNIFESP] Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] |
author_role |
author |
author2 |
Noronha, Samuel Marcos Ribeiro de [UNIFESP] Nogueira-de-Souza, Naiara Corrêa [UNIFESP] Carvalho, Cristina Valletta de [UNIFESP] Costa, Ana Maria Massad [UNIFESP] Linhares, Jose Juvenal [UNIFESP] Gomes, Mariano Tamura Vieira [UNIFESP] Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Corrêa, Silvana Aparecida Alves [UNIFESP] Noronha, Samuel Marcos Ribeiro de [UNIFESP] Nogueira-de-Souza, Naiara Corrêa [UNIFESP] Carvalho, Cristina Valletta de [UNIFESP] Costa, Ana Maria Massad [UNIFESP] Linhares, Jose Juvenal [UNIFESP] Gomes, Mariano Tamura Vieira [UNIFESP] Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] |
dc.subject.eng.fl_str_mv |
Angiotensin-converting enzyme Angiotensin II type 1 receptor Breast cancer Genotyping Polymorphisms |
topic |
Angiotensin-converting enzyme Angiotensin II type 1 receptor Breast cancer Genotyping Polymorphisms |
description |
Introduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I (AT(1))-receptor A1166C polymorphisms.Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer.Results. the frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2) ); and for AT(1)-receptor were: AA, AC and CC (in %; cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi(2)). the results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls.Conclusions. the ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. the ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible targer for developing genetic markers for breast cancer. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:52:18Z |
dc.date.available.fl_str_mv |
2016-01-24T13:52:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of the Renin-angiotensin-aldosterone System. London: Sage Publications Ltd, v. 10, n. 1, p. 51-58, 2009. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/31337 https://dx.doi.org/10.1177/1470320309102317 |
dc.identifier.issn.none.fl_str_mv |
1470-3203 |
dc.identifier.doi.none.fl_str_mv |
10.1177/1470320309102317 |
dc.identifier.wos.none.fl_str_mv |
WOS:000265789800008 |
identifier_str_mv |
Journal of the Renin-angiotensin-aldosterone System. London: Sage Publications Ltd, v. 10, n. 1, p. 51-58, 2009. 1470-3203 10.1177/1470320309102317 WOS:000265789800008 |
url |
https://repositorio.unifesp.br/handle/11600/31337 https://dx.doi.org/10.1177/1470320309102317 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of the Renin-angiotensin-aldosterone System |
dc.rights.driver.fl_str_mv |
http://www.uk.sagepub.com/aboutus/openaccess.htm info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.uk.sagepub.com/aboutus/openaccess.htm |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
51-58 |
dc.publisher.none.fl_str_mv |
Sage Publications Ltd |
publisher.none.fl_str_mv |
Sage Publications Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460241285840896 |