Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/28128 http://dx.doi.org/10.1139/V05-003 |
Resumo: | Synthesis, characterization, and biological activity of a new water-soluble Pd(II)-deoxyalliin (S-allyl-L-cysteine) complex are described in this article. Elemental and thermal analysis for the complex are consistent with the formula [Pd(C6H10NO2S)(2)]. C-13 NMR, H-1 NMR, and IR spectroscopy show coordination of the ligand to Pd(II) through S and N atoms in a square planar geometry. Final residue of the thermal treatment was identified as a mixture of PdO and metallic Pd. Antiproliferative assays using aqueous solutions of the complex against HeLa and TM5 tumor cells showed a pronounced activity of the complex even at low concentrations. After incubation for 24 h, the complex induced cytotoxic effect over HeLa cells when used at concentrations higher than 0.40 mmol/L. At lower concentrations, the complex was nontoxic, indicating its action is probably due to cell cycle arrest, rather than cell death. in agreement with these results, the flow cytometric analysis indicated that after incubation for 24 h at low concentrations of the complex cells are arrested in G0/G1. |
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Corbi, P. P.Massabni, A. C.Moreira, A. G.Medrano, F. J.Jasiulionis, M. G. [UNIFESP]Costa-Neto, C. M.UNESPUniversidade de São Paulo (USP)LNLSUniversidade Federal de São Paulo (UNIFESP)2016-01-24T12:37:37Z2016-01-24T12:37:37Z2005-02-01Canadian Journal of Chemistry-revue Canadienne de Chimie. Ottawa: Natl Research Council Canada, v. 83, n. 2, p. 104-109, 2005.0008-4042http://repositorio.unifesp.br/handle/11600/28128http://dx.doi.org/10.1139/V05-00310.1139/V05-003WOS:000228084200003Synthesis, characterization, and biological activity of a new water-soluble Pd(II)-deoxyalliin (S-allyl-L-cysteine) complex are described in this article. Elemental and thermal analysis for the complex are consistent with the formula [Pd(C6H10NO2S)(2)]. C-13 NMR, H-1 NMR, and IR spectroscopy show coordination of the ligand to Pd(II) through S and N atoms in a square planar geometry. Final residue of the thermal treatment was identified as a mixture of PdO and metallic Pd. Antiproliferative assays using aqueous solutions of the complex against HeLa and TM5 tumor cells showed a pronounced activity of the complex even at low concentrations. After incubation for 24 h, the complex induced cytotoxic effect over HeLa cells when used at concentrations higher than 0.40 mmol/L. At lower concentrations, the complex was nontoxic, indicating its action is probably due to cell cycle arrest, rather than cell death. in agreement with these results, the flow cytometric analysis indicated that after incubation for 24 h at low concentrations of the complex cells are arrested in G0/G1.UNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, BrazilUSP, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, BrazilLNLS, BR-13084971 Campinas, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microimunoparasitol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microimunoparasitol, BR-04023062 São Paulo, BrazilWeb of Science104-109engNatl Research Council CanadaCanadian Journal of Chemistry-revue Canadienne de Chimiepalladium( II)deoxyalliinS-allyl-L-cysteinetumor cellscancerSynthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/281282023-02-15 11:04:56.882metadata only accessoai:repositorio.unifesp.br:11600/28128Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:39.175902Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
title |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
spellingShingle |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin Corbi, P. P. palladium( II) deoxyalliin S-allyl-L-cysteine tumor cells cancer |
title_short |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
title_full |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
title_fullStr |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
title_full_unstemmed |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
title_sort |
Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin |
author |
Corbi, P. P. |
author_facet |
Corbi, P. P. Massabni, A. C. Moreira, A. G. Medrano, F. J. Jasiulionis, M. G. [UNIFESP] Costa-Neto, C. M. |
author_role |
author |
author2 |
Massabni, A. C. Moreira, A. G. Medrano, F. J. Jasiulionis, M. G. [UNIFESP] Costa-Neto, C. M. |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
UNESP Universidade de São Paulo (USP) LNLS Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Corbi, P. P. Massabni, A. C. Moreira, A. G. Medrano, F. J. Jasiulionis, M. G. [UNIFESP] Costa-Neto, C. M. |
dc.subject.eng.fl_str_mv |
palladium( II) deoxyalliin S-allyl-L-cysteine tumor cells cancer |
topic |
palladium( II) deoxyalliin S-allyl-L-cysteine tumor cells cancer |
description |
Synthesis, characterization, and biological activity of a new water-soluble Pd(II)-deoxyalliin (S-allyl-L-cysteine) complex are described in this article. Elemental and thermal analysis for the complex are consistent with the formula [Pd(C6H10NO2S)(2)]. C-13 NMR, H-1 NMR, and IR spectroscopy show coordination of the ligand to Pd(II) through S and N atoms in a square planar geometry. Final residue of the thermal treatment was identified as a mixture of PdO and metallic Pd. Antiproliferative assays using aqueous solutions of the complex against HeLa and TM5 tumor cells showed a pronounced activity of the complex even at low concentrations. After incubation for 24 h, the complex induced cytotoxic effect over HeLa cells when used at concentrations higher than 0.40 mmol/L. At lower concentrations, the complex was nontoxic, indicating its action is probably due to cell cycle arrest, rather than cell death. in agreement with these results, the flow cytometric analysis indicated that after incubation for 24 h at low concentrations of the complex cells are arrested in G0/G1. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-02-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:37:37Z |
dc.date.available.fl_str_mv |
2016-01-24T12:37:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Canadian Journal of Chemistry-revue Canadienne de Chimie. Ottawa: Natl Research Council Canada, v. 83, n. 2, p. 104-109, 2005. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/28128 http://dx.doi.org/10.1139/V05-003 |
dc.identifier.issn.none.fl_str_mv |
0008-4042 |
dc.identifier.doi.none.fl_str_mv |
10.1139/V05-003 |
dc.identifier.wos.none.fl_str_mv |
WOS:000228084200003 |
identifier_str_mv |
Canadian Journal of Chemistry-revue Canadienne de Chimie. Ottawa: Natl Research Council Canada, v. 83, n. 2, p. 104-109, 2005. 0008-4042 10.1139/V05-003 WOS:000228084200003 |
url |
http://repositorio.unifesp.br/handle/11600/28128 http://dx.doi.org/10.1139/V05-003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Canadian Journal of Chemistry-revue Canadienne de Chimie |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
104-109 |
dc.publisher.none.fl_str_mv |
Natl Research Council Canada |
publisher.none.fl_str_mv |
Natl Research Council Canada |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460229951782912 |