Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats

Detalhes bibliográficos
Autor(a) principal: Estevão,Lígia Reis Moura
Data de Publicação: 2013
Outros Autores: Mendonça,Fábio de Souza, Baratella-Evêncio,Liriane, Simões,Ricardo Santos, Barros,Maria Edna Gomes de, Arantes,Rosa Maria Esteves, Rachid,Milene Alvarenga, Evêncio-Neto,Joaquim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000300008
Resumo: PURPOSE: To evaluate the effects of aroeira (Schinus terebinthifolius) ointment on skin wound healing in rats. METHODS: Adult male rats (n=20) were divided into four groups of five animals each, as follows: G4, G7, G14 and G21, which corresponds to 4th, 7th, 14th and 21th days postoperatively. Each animal were made two incisions on the skin, including the subcutaneous tissue, in the right and left sides of thoracic region, separated by a distance of two inches. The right lesion was treated with base ointment (vaseline, lanolin); the left one was treated with base ointment containing 5% of aroeira oil. At the end of each experimental period the lesions were evaluated for the contraction degree. Then held the collection of fragments that were fixed in 10% formalin and processed for paraffin embedding. In the histological sections (5μm) was evaluated the morphology and quantified the collagen and blood vessels. The data obtained were submitted to ANOVA test complemented by Tukey-Kramer test (p<0.05). RESULTS: The contraction of the lesions was higher in wounds treated with aroeira oil than in controls at 7th and 14th days (p<0.01), whereas in the 21st day all lesions were already completely healed. The morphology showed granulation tissue more developed, with fibroblasts more bulky and collagen fibers more arranged in the experimental group at 4th, 7th and 14th days. The morphometry showed a significant increase in the quantification of collagen fibers in the experimental group at 7th and 14th days (p<0.05). CONCLUSION: The aroeira oil accelerates the healing process of wounds as a macroscopic, morphological and morphometrical analysis.
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spelling Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in ratsWound HealingAngiogenesis Inducing AgentsSkinPhytotherapyAnacardiaceaeRatsPURPOSE: To evaluate the effects of aroeira (Schinus terebinthifolius) ointment on skin wound healing in rats. METHODS: Adult male rats (n=20) were divided into four groups of five animals each, as follows: G4, G7, G14 and G21, which corresponds to 4th, 7th, 14th and 21th days postoperatively. Each animal were made two incisions on the skin, including the subcutaneous tissue, in the right and left sides of thoracic region, separated by a distance of two inches. The right lesion was treated with base ointment (vaseline, lanolin); the left one was treated with base ointment containing 5% of aroeira oil. At the end of each experimental period the lesions were evaluated for the contraction degree. Then held the collection of fragments that were fixed in 10% formalin and processed for paraffin embedding. In the histological sections (5μm) was evaluated the morphology and quantified the collagen and blood vessels. The data obtained were submitted to ANOVA test complemented by Tukey-Kramer test (p<0.05). RESULTS: The contraction of the lesions was higher in wounds treated with aroeira oil than in controls at 7th and 14th days (p<0.01), whereas in the 21st day all lesions were already completely healed. The morphology showed granulation tissue more developed, with fibroblasts more bulky and collagen fibers more arranged in the experimental group at 4th, 7th and 14th days. The morphometry showed a significant increase in the quantification of collagen fibers in the experimental group at 7th and 14th days (p<0.05). CONCLUSION: The aroeira oil accelerates the healing process of wounds as a macroscopic, morphological and morphometrical analysis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000300008Acta Cirúrgica Brasileira v.28 n.3 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013000300008info:eu-repo/semantics/openAccessEstevão,Lígia Reis MouraMendonça,Fábio de SouzaBaratella-Evêncio,LirianeSimões,Ricardo SantosBarros,Maria Edna Gomes deArantes,Rosa Maria EstevesRachid,Milene AlvarengaEvêncio-Neto,Joaquimeng2013-03-06T00:00:00Zoai:scielo:S0102-86502013000300008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-03-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
title Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
spellingShingle Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
Estevão,Lígia Reis Moura
Wound Healing
Angiogenesis Inducing Agents
Skin
Phytotherapy
Anacardiaceae
Rats
title_short Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
title_full Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
title_fullStr Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
title_full_unstemmed Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
title_sort Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats
author Estevão,Lígia Reis Moura
author_facet Estevão,Lígia Reis Moura
Mendonça,Fábio de Souza
Baratella-Evêncio,Liriane
Simões,Ricardo Santos
Barros,Maria Edna Gomes de
Arantes,Rosa Maria Esteves
Rachid,Milene Alvarenga
Evêncio-Neto,Joaquim
author_role author
author2 Mendonça,Fábio de Souza
Baratella-Evêncio,Liriane
Simões,Ricardo Santos
Barros,Maria Edna Gomes de
Arantes,Rosa Maria Esteves
Rachid,Milene Alvarenga
Evêncio-Neto,Joaquim
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Estevão,Lígia Reis Moura
Mendonça,Fábio de Souza
Baratella-Evêncio,Liriane
Simões,Ricardo Santos
Barros,Maria Edna Gomes de
Arantes,Rosa Maria Esteves
Rachid,Milene Alvarenga
Evêncio-Neto,Joaquim
dc.subject.por.fl_str_mv Wound Healing
Angiogenesis Inducing Agents
Skin
Phytotherapy
Anacardiaceae
Rats
topic Wound Healing
Angiogenesis Inducing Agents
Skin
Phytotherapy
Anacardiaceae
Rats
description PURPOSE: To evaluate the effects of aroeira (Schinus terebinthifolius) ointment on skin wound healing in rats. METHODS: Adult male rats (n=20) were divided into four groups of five animals each, as follows: G4, G7, G14 and G21, which corresponds to 4th, 7th, 14th and 21th days postoperatively. Each animal were made two incisions on the skin, including the subcutaneous tissue, in the right and left sides of thoracic region, separated by a distance of two inches. The right lesion was treated with base ointment (vaseline, lanolin); the left one was treated with base ointment containing 5% of aroeira oil. At the end of each experimental period the lesions were evaluated for the contraction degree. Then held the collection of fragments that were fixed in 10% formalin and processed for paraffin embedding. In the histological sections (5μm) was evaluated the morphology and quantified the collagen and blood vessels. The data obtained were submitted to ANOVA test complemented by Tukey-Kramer test (p<0.05). RESULTS: The contraction of the lesions was higher in wounds treated with aroeira oil than in controls at 7th and 14th days (p<0.01), whereas in the 21st day all lesions were already completely healed. The morphology showed granulation tissue more developed, with fibroblasts more bulky and collagen fibers more arranged in the experimental group at 4th, 7th and 14th days. The morphometry showed a significant increase in the quantification of collagen fibers in the experimental group at 7th and 14th days (p<0.05). CONCLUSION: The aroeira oil accelerates the healing process of wounds as a macroscopic, morphological and morphometrical analysis.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000300008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502013000300008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.28 n.3 2013
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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