Study of advanced rheumatoid arthritis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Engenharia Biomédica (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-31512014000100008 |
Resumo: | INTRODUCTION: Rheumatic diseases are considered public health problems affecting millions of people worldwide resulting in high and rising health-care costs. In this work, Fourier Transform Infrared spectroscopy associated to Partial Least Square regression (PLS) analysis was used to diagnose rheumatoid arthritis (RA) from human serum. METHODS: The sera of 94 individuals were collected, which included 47 from rheumatic patients and 47 from healthy individuals. The results from PLS analysis were compared to standard clinical trials such as anti-citrullinated peptide antibodies, C- Reactive protein, and Rheumatoid factor. RESULTS: For clinical diagnosis, the anti-citrullinated peptide antibodies of second generation proved to be the most specific to diagnosis rheumatoid arthritis even after long periods of drug therapy. CONCLUSIONS: The qualitative PLS analysis has shown higher values of IgM of RA group, but the difference was very small. The RA patients were under medication, which interfered with the IgM concentration. |
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Study of advanced rheumatoid arthritisFTIR spectroscopyHuman serumRheumatoid arthritisPartial Least SquareINTRODUCTION: Rheumatic diseases are considered public health problems affecting millions of people worldwide resulting in high and rising health-care costs. In this work, Fourier Transform Infrared spectroscopy associated to Partial Least Square regression (PLS) analysis was used to diagnose rheumatoid arthritis (RA) from human serum. METHODS: The sera of 94 individuals were collected, which included 47 from rheumatic patients and 47 from healthy individuals. The results from PLS analysis were compared to standard clinical trials such as anti-citrullinated peptide antibodies, C- Reactive protein, and Rheumatoid factor. RESULTS: For clinical diagnosis, the anti-citrullinated peptide antibodies of second generation proved to be the most specific to diagnosis rheumatoid arthritis even after long periods of drug therapy. CONCLUSIONS: The qualitative PLS analysis has shown higher values of IgM of RA group, but the difference was very small. The RA patients were under medication, which interfered with the IgM concentration.SBEB - Sociedade Brasileira de Engenharia Biomédica2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-31512014000100008Revista Brasileira de Engenharia Biomédica v.30 n.1 2014reponame:Revista Brasileira de Engenharia Biomédica (Online)instname:Sociedade Brasileira de Engenharia Biomédica (SBEB)instacron:SBEB10.4322/rbeb.2014.004info:eu-repo/semantics/openAccessCarvalho,Carolina da SilvaAndrade,Luiz Eduardo CoelhoKeusseyan,Silene PeresRangel,João LucasFerreira-Strixino,JulianaMartin,Airton AbrahãoRaniero,Leandro Joséeng2014-04-23T00:00:00Zoai:scielo:S1517-31512014000100008Revistahttp://www.scielo.br/rbebONGhttps://old.scielo.br/oai/scielo-oai.php||rbeb@rbeb.org.br1984-77421517-3151opendoar:2014-04-23T00:00Revista Brasileira de Engenharia Biomédica (Online) - Sociedade Brasileira de Engenharia Biomédica (SBEB)false |
dc.title.none.fl_str_mv |
Study of advanced rheumatoid arthritis |
title |
Study of advanced rheumatoid arthritis |
spellingShingle |
Study of advanced rheumatoid arthritis Carvalho,Carolina da Silva FTIR spectroscopy Human serum Rheumatoid arthritis Partial Least Square |
title_short |
Study of advanced rheumatoid arthritis |
title_full |
Study of advanced rheumatoid arthritis |
title_fullStr |
Study of advanced rheumatoid arthritis |
title_full_unstemmed |
Study of advanced rheumatoid arthritis |
title_sort |
Study of advanced rheumatoid arthritis |
author |
Carvalho,Carolina da Silva |
author_facet |
Carvalho,Carolina da Silva Andrade,Luiz Eduardo Coelho Keusseyan,Silene Peres Rangel,João Lucas Ferreira-Strixino,Juliana Martin,Airton Abrahão Raniero,Leandro José |
author_role |
author |
author2 |
Andrade,Luiz Eduardo Coelho Keusseyan,Silene Peres Rangel,João Lucas Ferreira-Strixino,Juliana Martin,Airton Abrahão Raniero,Leandro José |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho,Carolina da Silva Andrade,Luiz Eduardo Coelho Keusseyan,Silene Peres Rangel,João Lucas Ferreira-Strixino,Juliana Martin,Airton Abrahão Raniero,Leandro José |
dc.subject.por.fl_str_mv |
FTIR spectroscopy Human serum Rheumatoid arthritis Partial Least Square |
topic |
FTIR spectroscopy Human serum Rheumatoid arthritis Partial Least Square |
description |
INTRODUCTION: Rheumatic diseases are considered public health problems affecting millions of people worldwide resulting in high and rising health-care costs. In this work, Fourier Transform Infrared spectroscopy associated to Partial Least Square regression (PLS) analysis was used to diagnose rheumatoid arthritis (RA) from human serum. METHODS: The sera of 94 individuals were collected, which included 47 from rheumatic patients and 47 from healthy individuals. The results from PLS analysis were compared to standard clinical trials such as anti-citrullinated peptide antibodies, C- Reactive protein, and Rheumatoid factor. RESULTS: For clinical diagnosis, the anti-citrullinated peptide antibodies of second generation proved to be the most specific to diagnosis rheumatoid arthritis even after long periods of drug therapy. CONCLUSIONS: The qualitative PLS analysis has shown higher values of IgM of RA group, but the difference was very small. The RA patients were under medication, which interfered with the IgM concentration. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-31512014000100008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-31512014000100008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.4322/rbeb.2014.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
SBEB - Sociedade Brasileira de Engenharia Biomédica |
publisher.none.fl_str_mv |
SBEB - Sociedade Brasileira de Engenharia Biomédica |
dc.source.none.fl_str_mv |
Revista Brasileira de Engenharia Biomédica v.30 n.1 2014 reponame:Revista Brasileira de Engenharia Biomédica (Online) instname:Sociedade Brasileira de Engenharia Biomédica (SBEB) instacron:SBEB |
instname_str |
Sociedade Brasileira de Engenharia Biomédica (SBEB) |
instacron_str |
SBEB |
institution |
SBEB |
reponame_str |
Revista Brasileira de Engenharia Biomédica (Online) |
collection |
Revista Brasileira de Engenharia Biomédica (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Engenharia Biomédica (Online) - Sociedade Brasileira de Engenharia Biomédica (SBEB) |
repository.mail.fl_str_mv |
||rbeb@rbeb.org.br |
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1754820915099598848 |