Bone mineral density of Brazilian girls with juvenile dermatomyositis
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/2391 http://dx.doi.org/10.1590/S0100-879X2005000200020 |
Resumo: | We measured bone mineral density (BMD) in girls with juvenile dermatomyositis (JDM) considering multiple factors in order to determine if it could be used as a predictor of reduction in bone mass. A cross-sectional study of lumbar spine BMD (L2-L4) was conducted on 10 girls aged 7-16 years with JDM. A group of 20 age-matched healthy girls was used as control. Lumbar spine BMD was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in all patients and controls. Duration of disease and mean daily and cumulative steroid doses were calculated for all patients on the basis of their medical charts. JDM activity was determined on the basis of the presence of muscle weakness, cutaneous vasculitis and/or elevation of serum concentration of one or more skeletal muscle enzymes. Seven patients demonstrated osteopenia or osteoporosis. Lumbar BMD was significantly lower in the JDM patients than the age-matched healthy control girls (0.712 vs 0.878, respectively; Student t-test, P = 0.041). No significant correlation between BMD and age, height, Tanner stage, disease duration, corticosteroid use, or disease activity was observed in JDM girls, but a correlation was observed between BMD and weight (Pearson's correlation coefficient, r = 0.802). Patients with JDM may be at risk for a significant reduction in BMD that might contribute to further skeletal fragility. Our results suggest that reduced bone mass in JDM may be related to other intrinsic mechanisms in addition to steroid treatment and some aspects of the disease itself may contribute to this condition. |
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Castro, Tania Caroline Monteiro de [UNIFESP]Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Szejnfeld, Vera Lucia [UNIFESP]Len, Claudio Arnaldo [UNIFESP]Fonseca, A.s.m. daHilário, Maria Odete Esteves [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade Federal do Rio Grande do Norte Departamento de Pediatria2015-06-14T13:31:26Z2015-06-14T13:31:26Z2005-02-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 2, p. 309-313, 2005.0100-879Xhttp://repositorio.unifesp.br/handle/11600/2391http://dx.doi.org/10.1590/S0100-879X2005000200020S0100-879X2005000200020.pdfS0100-879X200500020002010.1590/S0100-879X2005000200020WOS:000227480900020We measured bone mineral density (BMD) in girls with juvenile dermatomyositis (JDM) considering multiple factors in order to determine if it could be used as a predictor of reduction in bone mass. A cross-sectional study of lumbar spine BMD (L2-L4) was conducted on 10 girls aged 7-16 years with JDM. A group of 20 age-matched healthy girls was used as control. Lumbar spine BMD was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in all patients and controls. Duration of disease and mean daily and cumulative steroid doses were calculated for all patients on the basis of their medical charts. JDM activity was determined on the basis of the presence of muscle weakness, cutaneous vasculitis and/or elevation of serum concentration of one or more skeletal muscle enzymes. Seven patients demonstrated osteopenia or osteoporosis. Lumbar BMD was significantly lower in the JDM patients than the age-matched healthy control girls (0.712 vs 0.878, respectively; Student t-test, P = 0.041). No significant correlation between BMD and age, height, Tanner stage, disease duration, corticosteroid use, or disease activity was observed in JDM girls, but a correlation was observed between BMD and weight (Pearson's correlation coefficient, r = 0.802). Patients with JDM may be at risk for a significant reduction in BMD that might contribute to further skeletal fragility. Our results suggest that reduced bone mass in JDM may be related to other intrinsic mechanisms in addition to steroid treatment and some aspects of the disease itself may contribute to this condition.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PediatriaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina InternaUniversidade Federal do Rio Grande do Norte Departamento de PediatriaUNIFESP, EPM, Depto. de PediatriaUNIFESP, EPM, Depto. de Medicina InternaSciELO309-313engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchDermatomyositisAdolescent girlsBone mineral densityOsteoporosisCorticosteroidsBone mineral density of Brazilian girls with juvenile dermatomyositisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2005000200020.pdfapplication/pdf449373${dspace.ui.url}/bitstream/11600/2391/1/S0100-879X2005000200020.pdf0b2fd26651d93b7866cff5bf03d17114MD51open accessTEXTS0100-879X2005000200020.pdf.txtS0100-879X2005000200020.pdf.txtExtracted texttext/plain19704${dspace.ui.url}/bitstream/11600/2391/21/S0100-879X2005000200020.pdf.txt6b20a43544f0c89de07be9524f1b04a0MD521open accessTHUMBNAILS0100-879X2005000200020.pdf.jpgS0100-879X2005000200020.pdf.jpgIM Thumbnailimage/jpeg5334${dspace.ui.url}/bitstream/11600/2391/23/S0100-879X2005000200020.pdf.jpg848f0d2e44b89fadd2ecd0e097c19b27MD523open access11600/23912023-06-05 19:57:15.665open accessoai:repositorio.unifesp.br:11600/2391Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:57:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
title |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
spellingShingle |
Bone mineral density of Brazilian girls with juvenile dermatomyositis Castro, Tania Caroline Monteiro de [UNIFESP] Dermatomyositis Adolescent girls Bone mineral density Osteoporosis Corticosteroids |
title_short |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
title_full |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
title_fullStr |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
title_full_unstemmed |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
title_sort |
Bone mineral density of Brazilian girls with juvenile dermatomyositis |
author |
Castro, Tania Caroline Monteiro de [UNIFESP] |
author_facet |
Castro, Tania Caroline Monteiro de [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Szejnfeld, Vera Lucia [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Fonseca, A.s.m. da Hilário, Maria Odete Esteves [UNIFESP] |
author_role |
author |
author2 |
Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Szejnfeld, Vera Lucia [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Fonseca, A.s.m. da Hilário, Maria Odete Esteves [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Rio Grande do Norte Departamento de Pediatria |
dc.contributor.author.fl_str_mv |
Castro, Tania Caroline Monteiro de [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Szejnfeld, Vera Lucia [UNIFESP] Len, Claudio Arnaldo [UNIFESP] Fonseca, A.s.m. da Hilário, Maria Odete Esteves [UNIFESP] |
dc.subject.eng.fl_str_mv |
Dermatomyositis Adolescent girls Bone mineral density Osteoporosis Corticosteroids |
topic |
Dermatomyositis Adolescent girls Bone mineral density Osteoporosis Corticosteroids |
description |
We measured bone mineral density (BMD) in girls with juvenile dermatomyositis (JDM) considering multiple factors in order to determine if it could be used as a predictor of reduction in bone mass. A cross-sectional study of lumbar spine BMD (L2-L4) was conducted on 10 girls aged 7-16 years with JDM. A group of 20 age-matched healthy girls was used as control. Lumbar spine BMD was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in all patients and controls. Duration of disease and mean daily and cumulative steroid doses were calculated for all patients on the basis of their medical charts. JDM activity was determined on the basis of the presence of muscle weakness, cutaneous vasculitis and/or elevation of serum concentration of one or more skeletal muscle enzymes. Seven patients demonstrated osteopenia or osteoporosis. Lumbar BMD was significantly lower in the JDM patients than the age-matched healthy control girls (0.712 vs 0.878, respectively; Student t-test, P = 0.041). No significant correlation between BMD and age, height, Tanner stage, disease duration, corticosteroid use, or disease activity was observed in JDM girls, but a correlation was observed between BMD and weight (Pearson's correlation coefficient, r = 0.802). Patients with JDM may be at risk for a significant reduction in BMD that might contribute to further skeletal fragility. Our results suggest that reduced bone mass in JDM may be related to other intrinsic mechanisms in addition to steroid treatment and some aspects of the disease itself may contribute to this condition. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-02-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:31:26Z |
dc.date.available.fl_str_mv |
2015-06-14T13:31:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 2, p. 309-313, 2005. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/2391 http://dx.doi.org/10.1590/S0100-879X2005000200020 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2005000200020.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2005000200020 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2005000200020 |
dc.identifier.wos.none.fl_str_mv |
WOS:000227480900020 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 2, p. 309-313, 2005. 0100-879X S0100-879X2005000200020.pdf S0100-879X2005000200020 10.1590/S0100-879X2005000200020 WOS:000227480900020 |
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http://repositorio.unifesp.br/handle/11600/2391 http://dx.doi.org/10.1590/S0100-879X2005000200020 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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309-313 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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