Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus

Detalhes bibliográficos
Autor(a) principal: Peracchi, Octávio Augusto Bedin [UNIFESP]
Data de Publicação: 2014
Outros Autores: Terreri, Maria Teresa Ramos Ascensão [UNIFESP], Munekata, Regina Viviane [UNIFESP], Len, Claudio Arnaldo [UNIFESP], Sarni, Roseli Oselka Saccardo [UNIFESP], Lazaretti-Castro, Marise [UNIFESP], Hilário, Maria Odete Esteves [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/8526
http://dx.doi.org/10.1590/1414-431X20143948
Resumo: We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations.
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spelling Peracchi, Octávio Augusto Bedin [UNIFESP]Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Munekata, Regina Viviane [UNIFESP]Len, Claudio Arnaldo [UNIFESP]Sarni, Roseli Oselka Saccardo [UNIFESP]Lazaretti-Castro, Marise [UNIFESP]Hilário, Maria Odete Esteves [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:47:14Z2015-06-14T13:47:14Z2014-08-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 721-726, 2014.0100-879Xhttp://repositorio.unifesp.br/handle/11600/8526http://dx.doi.org/10.1590/1414-431X20143948S0100-879X2014000800721.pdfS0100-879X201400080072110.1590/1414-431X20143948We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations.Universidade Federal de São Paulo (UNIFESP) Departamento de PediatriaUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Unidade de Reumatologia PediátricaUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de EndocrinologiaUNIFESP, Depto. de PediatriaUNIFESP, Depto. de Pediatria Unidade de Reumatologia PediátricaUNIFESP, Depto. de Medicina Divisão de EndocrinologiaSciELO721-726engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchJuvenile systemic lupus erythematosusVitamin DCalciumBone metabolismParathormoneLow serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2014000800721.pdfapplication/pdf80695${dspace.ui.url}/bitstream/11600/8526/1/S0100-879X2014000800721.pdf9422f25357ba9a2e84e24fd6bc42d731MD51open accessTEXTS0100-879X2014000800721.pdf.txtS0100-879X2014000800721.pdf.txtExtracted texttext/plain27648${dspace.ui.url}/bitstream/11600/8526/21/S0100-879X2014000800721.pdf.txt83aa43738938f12b79ff74a3a8ff02b2MD521open accessTHUMBNAILS0100-879X2014000800721.pdf.jpgS0100-879X2014000800721.pdf.jpgIM Thumbnailimage/jpeg6570${dspace.ui.url}/bitstream/11600/8526/23/S0100-879X2014000800721.pdf.jpg7b10d741b5c25dddf444de3e4339559cMD523open access11600/85262023-06-05 19:54:06.367open accessoai:repositorio.unifesp.br:11600/8526Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:54:06Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
title Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
spellingShingle Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
Peracchi, Octávio Augusto Bedin [UNIFESP]
Juvenile systemic lupus erythematosus
Vitamin D
Calcium
Bone metabolism
Parathormone
title_short Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
title_full Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
title_fullStr Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
title_full_unstemmed Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
title_sort Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus
author Peracchi, Octávio Augusto Bedin [UNIFESP]
author_facet Peracchi, Octávio Augusto Bedin [UNIFESP]
Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Munekata, Regina Viviane [UNIFESP]
Len, Claudio Arnaldo [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
Hilário, Maria Odete Esteves [UNIFESP]
author_role author
author2 Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Munekata, Regina Viviane [UNIFESP]
Len, Claudio Arnaldo [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
Hilário, Maria Odete Esteves [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Peracchi, Octávio Augusto Bedin [UNIFESP]
Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Munekata, Regina Viviane [UNIFESP]
Len, Claudio Arnaldo [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
Hilário, Maria Odete Esteves [UNIFESP]
dc.subject.eng.fl_str_mv Juvenile systemic lupus erythematosus
Vitamin D
Calcium
Bone metabolism
Parathormone
topic Juvenile systemic lupus erythematosus
Vitamin D
Calcium
Bone metabolism
Parathormone
description We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations.
publishDate 2014
dc.date.issued.fl_str_mv 2014-08-01
dc.date.accessioned.fl_str_mv 2015-06-14T13:47:14Z
dc.date.available.fl_str_mv 2015-06-14T13:47:14Z
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dc.identifier.citation.fl_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 721-726, 2014.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/8526
http://dx.doi.org/10.1590/1414-431X20143948
dc.identifier.issn.none.fl_str_mv 0100-879X
dc.identifier.file.none.fl_str_mv S0100-879X2014000800721.pdf
dc.identifier.scielo.none.fl_str_mv S0100-879X2014000800721
dc.identifier.doi.none.fl_str_mv 10.1590/1414-431X20143948
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 721-726, 2014.
0100-879X
S0100-879X2014000800721.pdf
S0100-879X2014000800721
10.1590/1414-431X20143948
url http://repositorio.unifesp.br/handle/11600/8526
http://dx.doi.org/10.1590/1414-431X20143948
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publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
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