Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation

Detalhes bibliográficos
Autor(a) principal: Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Data de Publicação: 2008
Outros Autores: Sarni, Roseli Oselka Saccardo [UNIFESP], Prado, Rogerio do [UNIFESP], Nascif, Ana Karina Soares [UNIFESP], D'Almeida, Vania, Hilário, Maria Odete Esteves [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/11600/42092
http://www.actareumatologica.pt/article_download.php?id=317
Resumo: Introduction: One of the mechanisms implicated in the pathogenesis of coronary heart disease in patients with juvenile systemic lupus erythematosus (SLE) is the hyperhomocysteinemia. Our aim was to follow patients with juvenile SLE and to identify the presence and the persistence of hyperhomocysteinemia.Methods: We studied 18 patients with juvenile SLE (median age 13.5 y). A survey of demographic and clinic data was performed based on patients records. The plasma homocysteine concentration was performed twice with a median interval of 1.5 years (1.3-2.5), and association with nutritional status, disease activity, renal involvement and use of methotrexate was sought. The plasma homocysteine concentration was also evaluated in 59 healthy controls, sex and age-matched to the patients.Results: Of the 18 patients with juvenile SLE, 16 (88.9%) were female and 13 (72.2%) had renal involvement. Five out of 18 patients (27.8%) persisted with increased concentration of plasma homocysteine (above the 90(th) percentile of the healthy group). The elevated concentration of homocysteine did not show statistically significant association neither with renal involvement (in the first dosage, p=0.676 and in the second, p=0.500), disease activity (in the first dosage, p=0.630 and in the second, p=0.182), overweight/obesity (in the first dosage, p=0.485 and in the second, p=0.288) nor with short stature (in the first dosage, p=0.202 and in the second, P=0.500).Conclusion: This study emphasizes the persistence of elevated concentration of homocysteine in some patients with juvenile SLE and the need for evaluations of therapeutic strategies and nutritional education aiming to reduce risk factors of cardiovascular disease.
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spelling Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Sarni, Roseli Oselka Saccardo [UNIFESP]Prado, Rogerio do [UNIFESP]Nascif, Ana Karina Soares [UNIFESP]D'Almeida, VaniaHilário, Maria Odete Esteves [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-15T12:47:31Z2018-06-15T12:47:31Z2008-01-01Acta Reumatologica Portuguesa. Alges: Publisaude-edicoes Medicas Lda, v. 33, n. 1, p. 57-62, 2008.0303-464Xhttp://repositorio.unifesp.br/11600/42092http://www.actareumatologica.pt/article_download.php?id=317WOS000254555700006.pdfWOS:000254555700006Introduction: One of the mechanisms implicated in the pathogenesis of coronary heart disease in patients with juvenile systemic lupus erythematosus (SLE) is the hyperhomocysteinemia. Our aim was to follow patients with juvenile SLE and to identify the presence and the persistence of hyperhomocysteinemia.Methods: We studied 18 patients with juvenile SLE (median age 13.5 y). A survey of demographic and clinic data was performed based on patients records. The plasma homocysteine concentration was performed twice with a median interval of 1.5 years (1.3-2.5), and association with nutritional status, disease activity, renal involvement and use of methotrexate was sought. The plasma homocysteine concentration was also evaluated in 59 healthy controls, sex and age-matched to the patients.Results: Of the 18 patients with juvenile SLE, 16 (88.9%) were female and 13 (72.2%) had renal involvement. Five out of 18 patients (27.8%) persisted with increased concentration of plasma homocysteine (above the 90(th) percentile of the healthy group). The elevated concentration of homocysteine did not show statistically significant association neither with renal involvement (in the first dosage, p=0.676 and in the second, p=0.500), disease activity (in the first dosage, p=0.630 and in the second, p=0.182), overweight/obesity (in the first dosage, p=0.485 and in the second, p=0.288) nor with short stature (in the first dosage, p=0.202 and in the second, P=0.500).Conclusion: This study emphasizes the persistence of elevated concentration of homocysteine in some patients with juvenile SLE and the need for evaluations of therapeutic strategies and nutritional education aiming to reduce risk factors of cardiovascular disease.Univ Fed Sao Paulo, Dept Pediat, Disciplina Alergia Imunol Clin & Reumatol, Unifesp EPM, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Pediat, Disciplina Alergia Imunol Clin & Reumatol, Unifesp EPM, Sao Paulo, BrazilWeb of Science57-62porPublisaude-edicoes Medicas LdaActa Reumatologica Portuguesajuvenile systemic lupus erythematosushomocysteinecardiovascular diseaseChildrenadolescentsHyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluationHiperhomocisteinemia em crianças e adolescentes com Lúpus Eritematoso Sistémico: avaliação evolutivainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000254555700006.pdfapplication/pdf78570${dspace.ui.url}/bitstream/11600/42092/1/WOS000254555700006.pdf75ac46783926b40a2d275281ee096ad5MD51open access11600/420922022-09-19 22:29:26.101open accessoai:repositorio.unifesp.br:11600/42092Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:21:10.374540Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
dc.title.alternative.pt.fl_str_mv Hiperhomocisteinemia em crianças e adolescentes com Lúpus Eritematoso Sistémico: avaliação evolutiva
title Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
spellingShingle Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
juvenile systemic lupus erythematosus
homocysteine
cardiovascular disease
Children
adolescents
title_short Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
title_full Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
title_fullStr Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
title_full_unstemmed Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
title_sort Hyperhomocysteinemia in children and adolescents with systemic lupus erythematosus: evolutive evaluation
author Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
author_facet Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
Prado, Rogerio do [UNIFESP]
Nascif, Ana Karina Soares [UNIFESP]
D'Almeida, Vania
Hilário, Maria Odete Esteves [UNIFESP]
author_role author
author2 Sarni, Roseli Oselka Saccardo [UNIFESP]
Prado, Rogerio do [UNIFESP]
Nascif, Ana Karina Soares [UNIFESP]
D'Almeida, Vania
Hilário, Maria Odete Esteves [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
Prado, Rogerio do [UNIFESP]
Nascif, Ana Karina Soares [UNIFESP]
D'Almeida, Vania
Hilário, Maria Odete Esteves [UNIFESP]
dc.subject.eng.fl_str_mv juvenile systemic lupus erythematosus
homocysteine
cardiovascular disease
Children
adolescents
topic juvenile systemic lupus erythematosus
homocysteine
cardiovascular disease
Children
adolescents
description Introduction: One of the mechanisms implicated in the pathogenesis of coronary heart disease in patients with juvenile systemic lupus erythematosus (SLE) is the hyperhomocysteinemia. Our aim was to follow patients with juvenile SLE and to identify the presence and the persistence of hyperhomocysteinemia.Methods: We studied 18 patients with juvenile SLE (median age 13.5 y). A survey of demographic and clinic data was performed based on patients records. The plasma homocysteine concentration was performed twice with a median interval of 1.5 years (1.3-2.5), and association with nutritional status, disease activity, renal involvement and use of methotrexate was sought. The plasma homocysteine concentration was also evaluated in 59 healthy controls, sex and age-matched to the patients.Results: Of the 18 patients with juvenile SLE, 16 (88.9%) were female and 13 (72.2%) had renal involvement. Five out of 18 patients (27.8%) persisted with increased concentration of plasma homocysteine (above the 90(th) percentile of the healthy group). The elevated concentration of homocysteine did not show statistically significant association neither with renal involvement (in the first dosage, p=0.676 and in the second, p=0.500), disease activity (in the first dosage, p=0.630 and in the second, p=0.182), overweight/obesity (in the first dosage, p=0.485 and in the second, p=0.288) nor with short stature (in the first dosage, p=0.202 and in the second, P=0.500).Conclusion: This study emphasizes the persistence of elevated concentration of homocysteine in some patients with juvenile SLE and the need for evaluations of therapeutic strategies and nutritional education aiming to reduce risk factors of cardiovascular disease.
publishDate 2008
dc.date.issued.fl_str_mv 2008-01-01
dc.date.accessioned.fl_str_mv 2018-06-15T12:47:31Z
dc.date.available.fl_str_mv 2018-06-15T12:47:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.citation.fl_str_mv Acta Reumatologica Portuguesa. Alges: Publisaude-edicoes Medicas Lda, v. 33, n. 1, p. 57-62, 2008.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/11600/42092
http://www.actareumatologica.pt/article_download.php?id=317
dc.identifier.issn.none.fl_str_mv 0303-464X
dc.identifier.file.none.fl_str_mv WOS000254555700006.pdf
dc.identifier.wos.none.fl_str_mv WOS:000254555700006
identifier_str_mv Acta Reumatologica Portuguesa. Alges: Publisaude-edicoes Medicas Lda, v. 33, n. 1, p. 57-62, 2008.
0303-464X
WOS000254555700006.pdf
WOS:000254555700006
url http://repositorio.unifesp.br/11600/42092
http://www.actareumatologica.pt/article_download.php?id=317
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