Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ana Flávia Costa da Silveira
Data de Publicação: 2017
Outros Autores: Teixeira, Róbson Ricardo, Oliveira, André Silva de, Souza, Ana Paula Martins de, Silva, Milene Lopes da, Paula, Sérgio Oliveira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.3390/molecules22030505
http://www.locus.ufv.br/handle/123456789/12391
Resumo: Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses. View Full-Text
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spelling Oliveira, Ana Flávia Costa da SilveiraTeixeira, Róbson RicardoOliveira, André Silva deSouza, Ana Paula Martins deSilva, Milene Lopes daPaula, Sérgio Oliveira de2017-10-25T14:04:28Z2017-10-25T14:04:28Z2017-03-221420-3049http://dx.doi.org/10.3390/molecules22030505http://www.locus.ufv.br/handle/123456789/12391Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses. View Full-TextengMolecules22(3), Mar. 2017DengueChikungunyaVirus enzymesAntiviralNatural productsPotential antivirals: Natural products targeting replication enzymes of dengue and chikungunya virusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALmolecules-22-00505-v2.pdfmolecules-22-00505-v2.pdftexto completoapplication/pdf2785462https://locus.ufv.br//bitstream/123456789/12391/1/molecules-22-00505-v2.pdf0f76009a3981055e74e80d0e1ae36929MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/12391/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILmolecules-22-00505-v2.pdf.jpgmolecules-22-00505-v2.pdf.jpgIM Thumbnailimage/jpeg2601https://locus.ufv.br//bitstream/123456789/12391/3/molecules-22-00505-v2.pdf.jpg35bcdc3065c2126284fa24e4544273fdMD53123456789/123912017-10-25 22:00:33.363oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452017-10-26T01:00:33LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
title Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
spellingShingle Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
Oliveira, Ana Flávia Costa da Silveira
Dengue
Chikungunya
Virus enzymes
Antiviral
Natural products
title_short Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
title_full Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
title_fullStr Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
title_full_unstemmed Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
title_sort Potential antivirals: Natural products targeting replication enzymes of dengue and chikungunya viruses
author Oliveira, Ana Flávia Costa da Silveira
author_facet Oliveira, Ana Flávia Costa da Silveira
Teixeira, Róbson Ricardo
Oliveira, André Silva de
Souza, Ana Paula Martins de
Silva, Milene Lopes da
Paula, Sérgio Oliveira de
author_role author
author2 Teixeira, Róbson Ricardo
Oliveira, André Silva de
Souza, Ana Paula Martins de
Silva, Milene Lopes da
Paula, Sérgio Oliveira de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Ana Flávia Costa da Silveira
Teixeira, Róbson Ricardo
Oliveira, André Silva de
Souza, Ana Paula Martins de
Silva, Milene Lopes da
Paula, Sérgio Oliveira de
dc.subject.pt-BR.fl_str_mv Dengue
Chikungunya
Virus enzymes
Antiviral
Natural products
topic Dengue
Chikungunya
Virus enzymes
Antiviral
Natural products
description Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses. View Full-Text
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-10-25T14:04:28Z
dc.date.available.fl_str_mv 2017-10-25T14:04:28Z
dc.date.issued.fl_str_mv 2017-03-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/molecules22030505
http://www.locus.ufv.br/handle/123456789/12391
dc.identifier.issn.none.fl_str_mv 1420-3049
identifier_str_mv 1420-3049
url http://dx.doi.org/10.3390/molecules22030505
http://www.locus.ufv.br/handle/123456789/12391
dc.language.iso.fl_str_mv eng
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dc.relation.ispartofseries.pt-BR.fl_str_mv 22(3), Mar. 2017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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publisher.none.fl_str_mv Molecules
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