Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil
Main Author: | |
---|---|
Publication Date: | 1992 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UnB |
Download full: | http://repositorio.unb.br/handle/10482/25353 https://dx.doi.org/10.1590/S0074-02761992000200004 |
Summary: | Five patients with asexual and sexual parasites of Plasmodium vivax were treated orally with 600 mg chloroquine diphosphate (hour 0) followed with 300 mg at 8, 24 and 48 h later. Primaquine phospate, 15 mg, was administered concurrently at h 0 and 24 h intervals for 14 days. Anopheles darlingi were fed before the first dose (h-0.5) and 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 36, 48, 60 and 72 h later. Mosquitoes were examined for oocysts on day 8 and for sporozoites on day 15 after infection. Four of the five patients studied were still infective to mosquitoes from 1-5 h after the first dose of chloroquine plus primaquine. One of these and one other patient, who vomited 15 min after the first dose, became inffective again at hours 10 and 12, respectively. Once produced, oocysts in mosquitoes fed on patients before, during and after chloroquine plus primaquine treatment appeared normal and produced sporozoite infected salivary glands. In view of these data , it is concluded that primaquine demonstrated rapid gametocytocidal activity and should be administred concurrently with chloroquine to reduce vivax malaria transmission. |
id |
UNB_cf76003fba1aff053c1b13f779f23de1 |
---|---|
oai_identifier_str |
oai:repositorio2.unb.br:10482/25353 |
network_acronym_str |
UNB |
network_name_str |
Repositório Institucional da UnB |
repository_id_str |
|
spelling |
Klein, Terry A.Tada, Mauro S.Lima, Jose B. P.Tang, Amazonia Toda2017-12-07T04:26:13Z2017-12-07T04:26:13Z1992Mem. Inst. Oswaldo Cruz,v.87,n.2,p.191-195,1992http://repositorio.unb.br/handle/10482/25353https://dx.doi.org/10.1590/S0074-02761992000200004Five patients with asexual and sexual parasites of Plasmodium vivax were treated orally with 600 mg chloroquine diphosphate (hour 0) followed with 300 mg at 8, 24 and 48 h later. Primaquine phospate, 15 mg, was administered concurrently at h 0 and 24 h intervals for 14 days. Anopheles darlingi were fed before the first dose (h-0.5) and 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 36, 48, 60 and 72 h later. Mosquitoes were examined for oocysts on day 8 and for sporozoites on day 15 after infection. Four of the five patients studied were still infective to mosquitoes from 1-5 h after the first dose of chloroquine plus primaquine. One of these and one other patient, who vomited 15 min after the first dose, became inffective again at hours 10 and 12, respectively. Once produced, oocysts in mosquitoes fed on patients before, during and after chloroquine plus primaquine treatment appeared normal and produced sporozoite infected salivary glands. In view of these data , it is concluded that primaquine demonstrated rapid gametocytocidal activity and should be administred concurrently with chloroquine to reduce vivax malaria transmission.Em processamentoInstituto Oswaldo Cruz, Ministério da SaúdeInfection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAnopheles darlingchloroquineprimaquineinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALvol87(f2)_024-028.pdfapplication/pdf254126http://repositorio2.unb.br/jspui/bitstream/10482/25353/1/vol87%28f2%29_024-028.pdf70d0848b10941ebb91e1aa845672508bMD51open access10482/253532023-10-09 12:10:00.224open accessoai:repositorio2.unb.br:10482/25353Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-10-09T15:10Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
title |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
spellingShingle |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil Klein, Terry A. Anopheles darling chloroquine primaquine |
title_short |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
title_full |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
title_fullStr |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
title_full_unstemmed |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
title_sort |
Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil |
author |
Klein, Terry A. |
author_facet |
Klein, Terry A. Tada, Mauro S. Lima, Jose B. P. Tang, Amazonia Toda |
author_role |
author |
author2 |
Tada, Mauro S. Lima, Jose B. P. Tang, Amazonia Toda |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Klein, Terry A. Tada, Mauro S. Lima, Jose B. P. Tang, Amazonia Toda |
dc.subject.keyword.pt_BR.fl_str_mv |
Anopheles darling chloroquine primaquine |
topic |
Anopheles darling chloroquine primaquine |
description |
Five patients with asexual and sexual parasites of Plasmodium vivax were treated orally with 600 mg chloroquine diphosphate (hour 0) followed with 300 mg at 8, 24 and 48 h later. Primaquine phospate, 15 mg, was administered concurrently at h 0 and 24 h intervals for 14 days. Anopheles darlingi were fed before the first dose (h-0.5) and 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 36, 48, 60 and 72 h later. Mosquitoes were examined for oocysts on day 8 and for sporozoites on day 15 after infection. Four of the five patients studied were still infective to mosquitoes from 1-5 h after the first dose of chloroquine plus primaquine. One of these and one other patient, who vomited 15 min after the first dose, became inffective again at hours 10 and 12, respectively. Once produced, oocysts in mosquitoes fed on patients before, during and after chloroquine plus primaquine treatment appeared normal and produced sporozoite infected salivary glands. In view of these data , it is concluded that primaquine demonstrated rapid gametocytocidal activity and should be administred concurrently with chloroquine to reduce vivax malaria transmission. |
publishDate |
1992 |
dc.date.issued.fl_str_mv |
1992 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:26:13Z |
dc.date.available.fl_str_mv |
2017-12-07T04:26:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Mem. Inst. Oswaldo Cruz,v.87,n.2,p.191-195,1992 |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/25353 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://dx.doi.org/10.1590/S0074-02761992000200004 |
identifier_str_mv |
Mem. Inst. Oswaldo Cruz,v.87,n.2,p.191-195,1992 |
url |
http://repositorio.unb.br/handle/10482/25353 https://dx.doi.org/10.1590/S0074-02761992000200004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
bitstream.url.fl_str_mv |
http://repositorio2.unb.br/jspui/bitstream/10482/25353/1/vol87%28f2%29_024-028.pdf |
bitstream.checksum.fl_str_mv |
70d0848b10941ebb91e1aa845672508b |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
|
_version_ |
1797405403110178816 |