Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy
Main Author: | |
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Publication Date: | 2008 |
Other Authors: | |
Format: | Article |
Language: | eng |
Source: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100012 |
Summary: | From the beginning of the AIDS epidemic, pneumocystis pneumonia (PCP) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality. As from 1996, the advent of the highly active antiretroviral therapy (HAART) has changed the characteristics of such epidemic by reducing its related diseases and, as a result, AIDS-related mortality. With the purpose to estimate PCP occurrence and HAART interference, 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002. Among them, 58 (15.5%) PCP cases were found. There was a higher occurrence of PCP in the group of patients in which HAART was not used, with 40 (69.0%) of the episodes. As regards the studied period, a tendency to a linear reduction in annual PCP incidence was observed. The mean of T CD4+ lymphocytes in the patients with PCP (117 cells/mm³) was significantly lower when compared to that of the other individuals (325 cells/mm³). Therefore, this study suggests a temporal reduction in PCP occurrence related to HAART use with higher T CD4+ lymphocyte counts. Nevertheless, this opportunistic infection still shows significant incidence in AIDS patients. (NCT00516581). |
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Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapyAIDSpneumocystis pneumoniaantiretroviral treatmentT CD4+ lymphocytesFrom the beginning of the AIDS epidemic, pneumocystis pneumonia (PCP) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality. As from 1996, the advent of the highly active antiretroviral therapy (HAART) has changed the characteristics of such epidemic by reducing its related diseases and, as a result, AIDS-related mortality. With the purpose to estimate PCP occurrence and HAART interference, 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002. Among them, 58 (15.5%) PCP cases were found. There was a higher occurrence of PCP in the group of patients in which HAART was not used, with 40 (69.0%) of the episodes. As regards the studied period, a tendency to a linear reduction in annual PCP incidence was observed. The mean of T CD4+ lymphocytes in the patients with PCP (117 cells/mm³) was significantly lower when compared to that of the other individuals (325 cells/mm³). Therefore, this study suggests a temporal reduction in PCP occurrence related to HAART use with higher T CD4+ lymphocyte counts. Nevertheless, this opportunistic infection still shows significant incidence in AIDS patients. (NCT00516581).Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100012Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.1 2008reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992008000100012info:eu-repo/semantics/openAccessBarbosa,A. N.Souza,L. R.eng2009-09-11T00:00:00Zoai:scielo:S1678-91992008000100012Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2009-09-11T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
title |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
spellingShingle |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy Barbosa,A. N. AIDS pneumocystis pneumonia antiretroviral treatment T CD4+ lymphocytes |
title_short |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
title_full |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
title_fullStr |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
title_full_unstemmed |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
title_sort |
Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy |
author |
Barbosa,A. N. |
author_facet |
Barbosa,A. N. Souza,L. R. |
author_role |
author |
author2 |
Souza,L. R. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Barbosa,A. N. Souza,L. R. |
dc.subject.por.fl_str_mv |
AIDS pneumocystis pneumonia antiretroviral treatment T CD4+ lymphocytes |
topic |
AIDS pneumocystis pneumonia antiretroviral treatment T CD4+ lymphocytes |
description |
From the beginning of the AIDS epidemic, pneumocystis pneumonia (PCP) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality. As from 1996, the advent of the highly active antiretroviral therapy (HAART) has changed the characteristics of such epidemic by reducing its related diseases and, as a result, AIDS-related mortality. With the purpose to estimate PCP occurrence and HAART interference, 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002. Among them, 58 (15.5%) PCP cases were found. There was a higher occurrence of PCP in the group of patients in which HAART was not used, with 40 (69.0%) of the episodes. As regards the studied period, a tendency to a linear reduction in annual PCP incidence was observed. The mean of T CD4+ lymphocytes in the patients with PCP (117 cells/mm³) was significantly lower when compared to that of the other individuals (325 cells/mm³). Therefore, this study suggests a temporal reduction in PCP occurrence related to HAART use with higher T CD4+ lymphocyte counts. Nevertheless, this opportunistic infection still shows significant incidence in AIDS patients. (NCT00516581). |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-91992008000100012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.1 2008 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
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1748958538015703040 |