Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment
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Publication Date: | 2007 |
Other Authors: | , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1111/j.1742-7843.2007.00070.x http://hdl.handle.net/11449/12774 |
Summary: | Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg/kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or Plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin. |
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Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessmentDoxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg/kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or Plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin.Univ Estadual Paulista, Botucatu Fac Med, Dept Internal Med, Botucatu, SP, BrazilUniv Estadual Paulista, Botucatu Fac Med, Dept Pathol, Botucatu, SP, BrazilTufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USAUniv Estadual Paulista, Botucatu Fac Med, Dept Internal Med, Botucatu, SP, BrazilUniv Estadual Paulista, Botucatu Fac Med, Dept Pathol, Botucatu, SP, BrazilBlackwell PublishingUniversidade Estadual Paulista (Unesp)Tufts UnivFerreira, Ana Lúcia dos Anjos [UNESP]Russell, Robert MitchellRocha, Noeme Sousa [UNESP]Placido Ladeira, Marcelo SadySalvadori, Daisy Maria Favero [UNESP]Munhoz Oliveira Nascimento, Maria CarolinaMatsui, MirnaCarvalho, Flavio AugustoTang, GuangwenMatsubara, Luiz Shiguero [UNESP]Matsubara, Beatriz Bojikian [UNESP]2014-05-20T13:37:02Z2014-05-20T13:37:02Z2007-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-24application/pdfhttp://dx.doi.org/10.1111/j.1742-7843.2007.00070.xBasic & Clinical Pharmacology & Toxicology. Oxford: Blackwell Publishing, v. 101, n. 1, p. 16-24, 2007.1742-7835http://hdl.handle.net/11449/1277410.1111/j.1742-7843.2007.00070.xWOS:000247681900003WOS000247681900003.pdf294005165084654150511187529809036309835137998766699097712234079560777359184692840000-0002-8188-8149Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBasic & Clinical Pharmacology & Toxicology2.6590,655info:eu-repo/semantics/openAccess2023-12-19T06:24:09Zoai:repositorio.unesp.br:11449/12774Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-19T06:24:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
title |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
spellingShingle |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment Ferreira, Ana Lúcia dos Anjos [UNESP] |
title_short |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
title_full |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
title_fullStr |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
title_full_unstemmed |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
title_sort |
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment |
author |
Ferreira, Ana Lúcia dos Anjos [UNESP] |
author_facet |
Ferreira, Ana Lúcia dos Anjos [UNESP] Russell, Robert Mitchell Rocha, Noeme Sousa [UNESP] Placido Ladeira, Marcelo Sady Salvadori, Daisy Maria Favero [UNESP] Munhoz Oliveira Nascimento, Maria Carolina Matsui, Mirna Carvalho, Flavio Augusto Tang, Guangwen Matsubara, Luiz Shiguero [UNESP] Matsubara, Beatriz Bojikian [UNESP] |
author_role |
author |
author2 |
Russell, Robert Mitchell Rocha, Noeme Sousa [UNESP] Placido Ladeira, Marcelo Sady Salvadori, Daisy Maria Favero [UNESP] Munhoz Oliveira Nascimento, Maria Carolina Matsui, Mirna Carvalho, Flavio Augusto Tang, Guangwen Matsubara, Luiz Shiguero [UNESP] Matsubara, Beatriz Bojikian [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Tufts Univ |
dc.contributor.author.fl_str_mv |
Ferreira, Ana Lúcia dos Anjos [UNESP] Russell, Robert Mitchell Rocha, Noeme Sousa [UNESP] Placido Ladeira, Marcelo Sady Salvadori, Daisy Maria Favero [UNESP] Munhoz Oliveira Nascimento, Maria Carolina Matsui, Mirna Carvalho, Flavio Augusto Tang, Guangwen Matsubara, Luiz Shiguero [UNESP] Matsubara, Beatriz Bojikian [UNESP] |
description |
Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg/kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or Plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-07-01 2014-05-20T13:37:02Z 2014-05-20T13:37:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1742-7843.2007.00070.x Basic & Clinical Pharmacology & Toxicology. Oxford: Blackwell Publishing, v. 101, n. 1, p. 16-24, 2007. 1742-7835 http://hdl.handle.net/11449/12774 10.1111/j.1742-7843.2007.00070.x WOS:000247681900003 WOS000247681900003.pdf 2940051650846541 5051118752980903 6309835137998766 6990977122340795 6077735918469284 0000-0002-8188-8149 |
url |
http://dx.doi.org/10.1111/j.1742-7843.2007.00070.x http://hdl.handle.net/11449/12774 |
identifier_str_mv |
Basic & Clinical Pharmacology & Toxicology. Oxford: Blackwell Publishing, v. 101, n. 1, p. 16-24, 2007. 1742-7835 10.1111/j.1742-7843.2007.00070.x WOS:000247681900003 WOS000247681900003.pdf 2940051650846541 5051118752980903 6309835137998766 6990977122340795 6077735918469284 0000-0002-8188-8149 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Basic & Clinical Pharmacology & Toxicology 2.659 0,655 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16-24 application/pdf |
dc.publisher.none.fl_str_mv |
Blackwell Publishing |
publisher.none.fl_str_mv |
Blackwell Publishing |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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