Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma
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Publication Date: | 2015 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1590/1678-7328 http://hdl.handle.net/11449/141865 |
Summary: | With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B origin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas by immunohistochemistry. Of 11 animals presenting immunohistochemical diagnosis of lymphoma, five had been diagnosed as Lymphoma by HE staining of histopathological slides and six had been classified as unspecific round cell neoplasia. All cases submitted to immunohistochemical examination were T-cell lymphomas. There was a positive correlation between cell proliferation and apoptosis. The comparison among histopathological and immunohistochemical results obtained in the cases examined in the present study suggested that immunohistochemistry is essential for the differentiation of round cell neoplasia. |
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Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphomaEstudo comparativo de histopatologia e imuno-histoquímica de tumores indefinidos de células redondas e caracterização de linfoma caninoDogHistopathologyImmunohistochemistryRound cell neoplasiaLymphomaCãoHistopatologiaImuno-histoquímicaNeoplasias de células redondasLinfomaWith the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B origin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas by immunohistochemistry. Of 11 animals presenting immunohistochemical diagnosis of lymphoma, five had been diagnosed as Lymphoma by HE staining of histopathological slides and six had been classified as unspecific round cell neoplasia. All cases submitted to immunohistochemical examination were T-cell lymphomas. There was a positive correlation between cell proliferation and apoptosis. The comparison among histopathological and immunohistochemical results obtained in the cases examined in the present study suggested that immunohistochemistry is essential for the differentiation of round cell neoplasia.Com o objetivo de sanar algumas dúvidas na área da oncologia veterinária, o presente artigo pretende comparar os resultados dos exames histopatológicos e imuno-histoquímicos de neoplasias de células redondas inespecíficas, realizar imunofenotipagem dos casos de linfoma canino e determinar o grau de proliferação e apoptose de linfomas. Dos 11 animais que apresentaram diagnóstico imuno-histoquímico de linfoma, cinco foram diagnosticados como linfoma por coloração HE das lâminas histopatológicas e seis foram classificados como neoplasia de células redondas inespecíficas. Todos os casos submetidos ao exame imuno-histoquímico foram de linfomas de células-T. Houve uma correlação positiva entre a proliferação celular e apoptose. A comparação entre os resultados histopatológicos e imuno-histoquímicos obtidos nos casos analisados sugeriu que a imuno-histoquímica é essencial para a diferenciação das neoplasias de células redondas.Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, BrasilPontifícia Universidade Católica do Paraná (PUC-PR), Curitiba, PR, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, BrasilUniversidade Estadual Paulista (Unesp)Pontifícia Universidade Católica do Paraná (PUC-PR)Machado, Luiz Henrique de Araújo [UNESP]Palumbo, Mariana Isa Poci [UNESP]Zahn, Fabíola Soares [UNESP]Amorim, Renée Laufer [UNESP]Farias, Marconi Rodrigues deWerner, JulianaTorres Neto, Rafael [UNESP]Rodrigues, Jéssica Correa [UNESP]Oliveira, Fernanda Cristina [UNESP]2016-07-19T13:51:12Z2016-07-19T13:51:12Z2015-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article32-36application/pdfhttp://dx.doi.org/10.1590/1678-7328Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Escola de Veterinária, v. 67, n. 1, p. 32-36, 2015.0959-4493http://hdl.handle.net/11449/14186510.1590/1678-7328S0102-09352015000100032S0102-09352015000100032.pdf97958290221081051694600251341732Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinária e Zootecnia1.2700,629info:eu-repo/semantics/openAccess2023-10-19T06:06:25Zoai:repositorio.unesp.br:11449/141865Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:20:26.606786Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma Estudo comparativo de histopatologia e imuno-histoquímica de tumores indefinidos de células redondas e caracterização de linfoma canino |
title |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma |
spellingShingle |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma Machado, Luiz Henrique de Araújo [UNESP] Dog Histopathology Immunohistochemistry Round cell neoplasia Lymphoma Cão Histopatologia Imuno-histoquímica Neoplasias de células redondas Linfoma |
title_short |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma |
title_full |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma |
title_fullStr |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma |
title_full_unstemmed |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma |
title_sort |
Comparative study of histopathology and immunohistochemistry of indefinite round cell cutaneous tumors and characterization of canine lymphoma |
author |
Machado, Luiz Henrique de Araújo [UNESP] |
author_facet |
Machado, Luiz Henrique de Araújo [UNESP] Palumbo, Mariana Isa Poci [UNESP] Zahn, Fabíola Soares [UNESP] Amorim, Renée Laufer [UNESP] Farias, Marconi Rodrigues de Werner, Juliana Torres Neto, Rafael [UNESP] Rodrigues, Jéssica Correa [UNESP] Oliveira, Fernanda Cristina [UNESP] |
author_role |
author |
author2 |
Palumbo, Mariana Isa Poci [UNESP] Zahn, Fabíola Soares [UNESP] Amorim, Renée Laufer [UNESP] Farias, Marconi Rodrigues de Werner, Juliana Torres Neto, Rafael [UNESP] Rodrigues, Jéssica Correa [UNESP] Oliveira, Fernanda Cristina [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Pontifícia Universidade Católica do Paraná (PUC-PR) |
dc.contributor.author.fl_str_mv |
Machado, Luiz Henrique de Araújo [UNESP] Palumbo, Mariana Isa Poci [UNESP] Zahn, Fabíola Soares [UNESP] Amorim, Renée Laufer [UNESP] Farias, Marconi Rodrigues de Werner, Juliana Torres Neto, Rafael [UNESP] Rodrigues, Jéssica Correa [UNESP] Oliveira, Fernanda Cristina [UNESP] |
dc.subject.por.fl_str_mv |
Dog Histopathology Immunohistochemistry Round cell neoplasia Lymphoma Cão Histopatologia Imuno-histoquímica Neoplasias de células redondas Linfoma |
topic |
Dog Histopathology Immunohistochemistry Round cell neoplasia Lymphoma Cão Histopatologia Imuno-histoquímica Neoplasias de células redondas Linfoma |
description |
With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B origin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas by immunohistochemistry. Of 11 animals presenting immunohistochemical diagnosis of lymphoma, five had been diagnosed as Lymphoma by HE staining of histopathological slides and six had been classified as unspecific round cell neoplasia. All cases submitted to immunohistochemical examination were T-cell lymphomas. There was a positive correlation between cell proliferation and apoptosis. The comparison among histopathological and immunohistochemical results obtained in the cases examined in the present study suggested that immunohistochemistry is essential for the differentiation of round cell neoplasia. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 2016-07-19T13:51:12Z 2016-07-19T13:51:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-7328 Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Escola de Veterinária, v. 67, n. 1, p. 32-36, 2015. 0959-4493 http://hdl.handle.net/11449/141865 10.1590/1678-7328 S0102-09352015000100032 S0102-09352015000100032.pdf 9795829022108105 1694600251341732 |
url |
http://dx.doi.org/10.1590/1678-7328 http://hdl.handle.net/11449/141865 |
identifier_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Escola de Veterinária, v. 67, n. 1, p. 32-36, 2015. 0959-4493 10.1590/1678-7328 S0102-09352015000100032 S0102-09352015000100032.pdf 9795829022108105 1694600251341732 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia 1.270 0,629 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
32-36 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128498633539584 |