Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
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Publication Date: | 2023 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1371/journal.pone.0266985 http://hdl.handle.net/11449/248141 |
Summary: | Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor. |
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Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortiumPurpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.U.S. National Library of MedicineNational Human Genome Research InstituteNational Institutes of HealthNational Institute of Neurological Disorders and StrokeCanadian Thoracic SocietyNational Center for Advancing Translational SciencesMedical Intensive Care Unit Bordeaux University HospitalInserm Bordeaux Population Health Research Center UMR 1219 Inria BSO Team SISTM University of BordeauxDepartment of Biomedical Informatics University of KentuckyDepartment of Legal Economic and Social Sciences University Magna Graecia of CatanzaroHealth Catalyst INC.Department of Electrical Computer and Biomedical Engineering University of PaviaDepartment of Surgery ASST Pavia Lombardia Region Health SystemBIOMERIS (BIOMedical Research Informatics Solutions)Clinical Research Unit of Botucatu Medical School São Paulo State UniversityPediatric emergency Department Hôpital Necker-Enfants Malades Assistance Public-Hôpitaux de ParisNational Center for Infectious Diseases Tan Tock Seng HospitalDepartments of Biomedical Informatics Pediatrics Cincinnati Children’s Hospital Medical Center University of CincinnatiBIG-ARC The University of Texas Health Science Center at Houston School of Biomedical InformaticsDepartment of Pediatrics Medical University of South CarolinaDepartment of Biomedical Informatics Harvard Medical SchoolInter-nal Medicine Department Botucatu Medical School São Paulo State UniversityDepartment of Surgery St. Luke’s University Health NetworkInstitute for Biomedical Informatics University of Pennsylvania Perelman School of MedicineDepartment of Medicine David Geffen School of Medicine at UCLADepartment of Medicine Division of Nephrology Ente Ospedaliero CantonaleIT Department-Innovation & Data APHP Greater Paris University HospitalIT Department ASST PaviaHealth Informatics Hospital Universitario 12 de OctubreStrategy and Transformation Department APHP Greater Paris University HospitalDepartment of Biomedical Informatics Cincinnati Children’s Hospital Medical CenterTechnical University of MunichDigital Research Informatics and Virtual Environments (DRIVE) Great Ormond Street Hospital for ChildrenScientific Direction IRCCS Ca’ Granda Ospedale Maggiore Policlinico di MilanoDepartment of Pediatrics Harvard Medical SchoolNorth Carolina Translational and Clinical Sciences (NC TraCS) Institute UNC Chapel HillIT department Innovation & Data APHP Greater Paris University HospitalDivision of Infectious Diseases I Fondazione I.R.C.C.S. Policlinico San MatteoDepartment of Cardiology Boston Children’s Hospital Harvard Medical SchoolDepartment of Biomedical Informatics HEGP APHP Greater Paris-University HospitalDepartment of Medical and Surgical Sciences Data Analytics Research Center University Magna Graecia of CatanzaroDepartment of Anesthesia St. Luke’s University Health NetworkDipar-timento di Medicina dei Sistemi Infectious and Tropical Disease Unit Padua University HospitalUniversité Paris-Saclay Inria CEAINRIA Sophia-Antipolis–ZENITH team LIRMMComputational Health Informatics Program Boston-Children’s HospitalDepartment of Internal Medicine University of KentuckyUnit of Internal Medicine and Endocrinology Istituti Clinici Scientifici Maugeri SpA SB IRCCSUOC Ricerca Innovazione e Brand reputation ASST Papa Giovanni XXIIIPopulation Health and Data Science MAVERIC VA Boston Healthcare SystemInformatics Institute University of Alabama at BirminghamIAM unit INSERM Bordeaux Population Health ERIAS TEAM Bordeaux University Hospital ERIAS—Inserm U1219 BPHBiomedical Informatics Center Medical University of South CarolinaDepartment of Electrical Computer and Biomedical-Engineering University of PaviaClinical Research Informatics Boston Children’s HospitalIT department Innovation & Data (APHP) UMRS1142 (INSERM) APHP Greater Paris University Hospital INSERMDepartment of Biomedical and Health Informatics Children’s Hospital of PhiladelphiaDepartment of Biostatistics Harvard T.H. Chan School of Public HealthVA Informatics and Computing Infrastructure VA Salt Lake City Health Care SystemSED/SIERRA Inria Centre de ParisDepartment of Medicine Massachusetts General HospitalHealth Information Technology & Services University of MichiganHeinrich-Lanz-Center for Digital Health University Medicine Mannheim Heidelberg UniversityDepartment of Computational Biology and Bioinformatics University of MichiganBiostatistics Perelman School of Medicine The University of PennsylvaniaDepartment of Anesthesiology Critical Care and Pain Medicine Computational Health Informatics Program Boston Children’s HospitalDepartment of Surgical Medical Sciences University of CatanzaroDepartment of Learning Health Sciences University of Michigan Medical SchoolInstitute of Digitalization in Medicine Faculty of Medicine and Medical Center University of FreiburgInstitute of Medical Biometry and Statistics Faculty of Medicine and Medical Center University of FreiburgMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare SystemDepartment of Biostatistics-Epidemiology and Informatices University of Pennsylvania Perelman School of MedicineDepartment of Biostatistics and Bioinformatics Duke UniversityDepartment of Preventive Medicine Northwestern UniversityDepartment of Biomedical Informatics HEGP APHP Greater Paris University HospitalDivision of Biomedical Informatics Department of Internal Medicine University of KentuckyCenter for Precision Psychiatry Massachusetts General HospitalDepartment of Critical Care Medicine Children’s Hospital of PIttsburghMedical University of South CarolinaDepartment of Pediatrics Division of Human Genetics The Children’s Hospital of Philadelphia The Perelman School of Medicine The University of PennsylvaniaCenter for Medical Information and Communication Technology University Hospital ErlangenRenaissance Computing Institute Department of Computer Science University of North Carolina Chapel HillClinical Research Unit Saint Antoine Hospital APHP Greater Paris University HospitalClevy.ioDepartment of Biostatistics Harvard T. H. Chan School of Public HealthDepartment of Anaesthesia National University Health SystemDepartment of Biostatistics Epidemiology and Informatics University of Pennsylvania Perelman School of MedicineMichigan Institute for Clinical and Health Research (MICHR) Informatics University of MichiganLaboratory of Informatics and Systems Engineering for Clinical Research Istituti Clinici Scientifici Maugeri SpA SB IRCCSComputational Health Informatics Program Boston Children’s HospitalHarvard Catalyst Harvard Medical SchoolClin-ical Research Unit Paris Saclay APHP Greater Paris University HospitalMedical Informatics Center Hospital das Clínicas Faculty of Medicine of Botucatu Clinics hospital of the Botucatu Medical School São Paulo State UniversityDepartment of Surgery Beth Israel Deaconess Medical CenterDepartment of Anesthesiology and Critical Care Children’s Hospital of PhiladelphiaDepartment of Internal Medicine Division of Medical Informatics University of Kansas-Medical CenterENS PSL UniversityDepartment of Medical and Surgical Sciences University Magna Graecia of CatanzaroInternal Medicine Department of Botucatu Medical School São Paulo State UniversityIAM unit Bordeaux University HospitalDepartment of Biomedical Health Informatics Children’s Hospital of PhiladelphiaDepartment of Computational Biomedicine Cedars-Sinai Medical CenterPediatric Infectious Disease Department Hospital Universitario 12 de OctubreDepartment of Biostatistics Epidemiology and Informatics Institute for Biomedical Informatics University of Pennsylvania Perelman School of MedicineDepartment of Biomedical Informatics University of PittsburghDepartment of Infectious Diseases Great Ormond Street Hospital for ChildrenDepartment of Neurology Massachusetts General HospitalHarvard Catalyst The Harvard Clinical and Translational Science Center Harvard Medical SchoolDepartment of biomedical informatics Hôpital Necker-Enfants Malade Assistance Publique Hôpitaux de Paris (APHP) University of ParisDepartment of Biomedical informatics WiSDM National University Health System SingaporeDepartment of Psychiatry University of Pennsylvania Perelman School of MedicineComputational Health Informatics Program Department of Pediatrics Boston Children’s Hospital Harvard Medical SchoolDept of Computational Medicine & Bioinformatics Internal Medicine Human Genetics School of Public Health University of MichiganCTSI WFBMI Wake Forest School of MedicineDepartment of Internal Medicine Division of Medical Informatics University Of Kansas Medical CenterDepartment of Surgery Beth Israel Deaconess Medical Center Harvard Medical SchoolNC TraCS Institute UNC Chapel HillDepartment of Preventive Medicine Northwestern University Feinberg School of MedicineDepartment of Medical Informatics University of Erlangen-NürnbergClinical Research Unit São Paulo State UniversityOffice of Research and Development Department of Veterans Affairs Department of Veterans AffairsDivi-sion of Infectious Diseases Department of Medicine II Medical Center–University of Freiburg Faculty of MedicineBiomedical Data Science Lab ITACA Institute Universitat Politècnica de ValènciaDepartment of Pediatrics (Critical Care) Northwestern University Feinberg School of MedicineNurse departament of FMB—medicine school of Botucatu Clinical Research Unit of Botucatu Medical School São Paulo State UniversityASST Pavia Lombardia Region Health System Management Engineer DirectionData Analytics Center University of Pennsylvania Health SystemDepartment of Anesthesiology University Hospital Erlangen FAU Erlangen-NürnbergDigital Research Informatics and Virtual Environments (DRIVE) Great Ormond Street Hospital for Children NIHR BRCDepartment of Biostatistics and Biomedical Informatics Hôpital Saint-Louis APHP Greater Paris University Hospital Paris UniversityDalla Lana School of Public Health University of TorontoMICHR Informatics University of MichiganCHIP Boston Children’s HospitalDepartment of Neurology University of Pittsburgh Medical CenterCritical Care Medicine Department of Medicine St. Luke’s University Health NetworkDepartment of Pediatrics-Section of Nephrology Brenner Children’s Wake Forest University School of MedicineDepartment of Medicine National University HospitalDepartment of Biomedical Health Informatics The Department of Pediatrics The Children’s Hospital of Philadelphia The University of Pennsylvania Perelman Medical SchoolInstitute of Medical Biometry and Statistics Institute of Medical Biometry and Statistics Medical Center University of FreiburgYong Loo Lin School of Medicine National University of SingaporeDepartment of Medical and Surgical Sciences Infectious and Tropical Disease Unit University Magna Graecia of CatanzaroClinical & Translational Science Institute Medical College of WisconsinUniversité Paris-Saclay Inria CEA Montréal Neurological Institute McGill UniversitySequeL Inria Lille Villeneuved’AscqRespiratory Department ICS S. Maugeri IRCCS Pavia ItalyDepartment of Health Management and Informatics University of MissouriDepartment of Neurology University of PittsburghDepartment of Veterans Affairs, 1100 First Street, NWUniversity of PittsburghDepartment of Anesthesiology and Critical Care Medicine Children’s Hospital of Philadelphia University of PennsylvaniaDepartments of Information Services Biomedical Informatics Pediatrics Cincinnati Children’s Hospital Medical Center University of CincinnatiDepartment of Oncology ASST Papa Giovanni XXIIIClinical Research Unit of Botucatu Medical School São Paulo State UniversityInter-nal Medicine Department Botucatu Medical School São Paulo State UniversityMedical Informatics Center Hospital das Clínicas Faculty of Medicine of Botucatu Clinics hospital of the Botucatu Medical School São Paulo State UniversityInternal Medicine Department of Botucatu Medical School São Paulo State UniversityClinical Research Unit São Paulo State UniversityNurse departament of FMB—medicine school of Botucatu Clinical Research Unit of Botucatu Medical School São Paulo State UniversityU.S. National Library of Medicine: 1R01LM013337National Human Genome Research Institute: 3U01HG008685-05S2National Institutes of Health: R01LM012095National Institutes of Health: R01LM013345National Institute of Neurological Disorders and Stroke: R01NS098023National Institutes of Health: U01TR003528Canadian Thoracic Society: UL1 TR001857National Institutes of Health: UL1-TR001878National Institutes of Health: UL1TR000005National Institutes of Health: UL1TR001857National Center for Advancing Translational Sciences: UL1TR002240Canadian Thoracic Society: UL1TR002366National Institutes of Health: UL1TR002541Bordeaux University HospitalUniversity of BordeauxUniversity of KentuckyUniversity Magna Graecia of CatanzaroINC.University of PaviaLombardia Region Health SystemBIOMERIS (BIOMedical Research Informatics Solutions)Universidade Estadual Paulista (UNESP)Assistance Public-Hôpitaux de ParisTan Tock Seng HospitalUniversity of CincinnatiSchool of Biomedical InformaticsMedical University of South CarolinaHarvard Medical SchoolSt. Luke’s University Health NetworkPerelman School of MedicineDavid Geffen School of Medicine at UCLAEnte Ospedaliero CantonaleAPHP Greater Paris University HospitalASST PaviaHospital Universitario 12 de OctubreCincinnati Children’s Hospital Medical CenterTechnical University of MunichGreat Ormond Street Hospital for ChildrenIRCCS Ca’ Granda Ospedale Maggiore Policlinico di MilanoUNC Chapel HillFondazione I.R.C.C.S. Policlinico San MatteoAPHP Greater Paris-University HospitalPadua University HospitalCEALIRMMBoston-Children’s HospitalIstituti Clinici Scientifici Maugeri SpA SB IRCCSASST Papa Giovanni XXIIIVA Boston Healthcare SystemUniversity of Alabama at BirminghamERIAS—Inserm U1219 BPHBoston Children’s HospitalINSERMChildren’s Hospital of PhiladelphiaHarvard T.H. Chan School of Public HealthVA Salt Lake City Health Care SystemInria Centre de ParisMassachusetts General HospitalUniversity of MichiganHeidelberg UniversityThe University of PennsylvaniaUniversity of CatanzaroUniversity of Michigan Medical SchoolUniversity of FreiburgDuke UniversityNorthwestern UniversityChildren’s Hospital of PIttsburghUniversity Hospital ErlangenChapel HillClevy.ioHarvard T. H. Chan School of Public HealthNational University Health SystemBeth Israel Deaconess Medical CenterUniversity of Kansas-Medical CenterPSL UniversityCedars-Sinai Medical CenterUniversity of PittsburghUniversity of ParisNational University Health System SingaporeWake Forest School of MedicineUniversity Of Kansas Medical CenterNorthwestern University Feinberg School of MedicineUniversity of Erlangen-NürnbergDepartment of Veterans AffairsFaculty of MedicineUniversitat Politècnica de ValènciaDirectionUniversity of Pennsylvania Health SystemFAU Erlangen-NürnbergGreat Ormond Street Hospital for Children NIHR BRCParis UniversityUniversity of TorontoUniversity of Pittsburgh Medical CenterWake Forest University School of MedicineNational University HospitalThe University of Pennsylvania Perelman Medical SchoolNational University of SingaporeMedical College of WisconsinMcGill UniversityVilleneuved’AscqICS S. Maugeri IRCCS Pavia ItalyUniversity of MissouriUniversity of PennsylvaniaOrieux, ArthurFerté, ThomasJouhet, VianneyAaron, James R.Agapito, GiuseppeAlbayrak, AdemAlbi, GiuseppeAlessiani, MarioAlloni, AnnaAmendola, Danilo F. [UNESP]Angoulvant, FrançoisAnthony, Li L.L.J.Aronow, Bruce J.Ashraf, FatimaAtz, AndrewAvillach, PaulPanickan, Vidul AyakulangaraAzevedo, Paula S. 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[UNESP]Marwaha, Jayson S.Masino, Aaron J.Mazzitelli, MariaMazzotti, Diego R.Mensch, ArthurMilano, MariannaMinicucci, Marcos F. [UNESP]Moal, BertrandAhooyi, Taha MohseniMoore, Jason H.Moraleda, CintaMorris, Jeffrey S.Morris, MicheleMoshal, Karyn L.Mousavi, SajadMowery, Danielle L.Murad, Douglas A.Murphy, Shawn N.Naughton, Thomas P.Neto, Carlos Tadeu Breda [UNESP]Neuraz, AntoineNewburger, JaneNgiam, Kee YuanNjoroge, Wanjiku F.M.Norman, James B.Obeid, JihadOkoshi, Marina P. [UNESP]Olson, Karen L.Omenn, Gilbert S.Orlova, NinaOstasiewski, Brian D.Palmer, Nathan P.Paris, NicolasPatel, Lav P.Pedrera-Jiménez, MiguelPfaff, Ashley C.Pfaff, Emily R.Pillion, DaniellePizzimenti, SaraPriya, TanuProkosch, Hans U.Prudente, Robson A. [UNESP]Prunotto, AndreaQuirós-González, VíctorRamoni, Rachel B.Raskin, MarynaRieg, SiegbertRoig-Domínguez, GustavoRojo, PabloRubio-Mayo, PaulaSacchi, PaoloSáez, CarlosSalamanca, ElisaSamayamuthu, Malarkodi JebathilagamSanchez-Pinto, L. NelsonSandrin, ArnaudSanthanam, NandhiniSantos, Janaina C.C. [UNESP]Sanz Vidorreta, Fernando J.Savino, MariaSchriver, Emily R.Schubert, PetraSchuettler, JuergenScudeller, LuigiaSebire, Neil J.Serrano-Balazote, PabloSerre, PatriciaSerret-Larmande, ArnaudShah, MohsinAbad, Zahra Shakeri HosseinSilvio, DomenickSliz, PiotrSon, JiyeonSonday, CharlesSouth, Andrew M.Sperotto, FrancescaSpiridou, AnastasiaStrasser, Zachary H.Tan, Amelia L.M.Tan, Bryce W.Q.Tan, Byorn W.L.Tanni, Suzana E. [UNESP]Taylor, Deanne M.Terriza-Torres, Ana I.Tibollo, ValentinaTippmann, PatricToh, Emma M.S.Torti, CarloTrecarichi, Enrico M.Vallejos, Andrew K.Varoquaux, GaelVella, Margaret E.Verdy, GuillaumeVie, Jill-JênnVisweswaran, ShyamVitacca, MicheleWagholikar, Kavishwar B.Waitman, Lemuel R.Wang, XuanWassermann, DemianWeber, Griffin M.Wolkewitz, MartinWong, ScottXia, ZongqiXiong, XinYe, YeYehya, NadirYuan, WilliamZachariasse, Joany M.Zahner, Janet J.Zambelli, AlbertoZhang, Harrison G.Zöller, DanielaZuccaro, ValentinaZucco, Chiara2023-07-29T13:35:35Z2023-07-29T13:35:35Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0266985PLoS ONE, v. 18, n. 1 January, 2023.1932-6203http://hdl.handle.net/11449/24814110.1371/journal.pone.02669852-s2.0-85145641542Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONEinfo:eu-repo/semantics/openAccess2023-07-29T13:35:39Zoai:repositorio.unesp.br:11449/248141Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:35:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
title |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
spellingShingle |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium Orieux, Arthur |
title_short |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
title_full |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
title_fullStr |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
title_full_unstemmed |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
title_sort |
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
author |
Orieux, Arthur |
author_facet |
Orieux, Arthur Ferté, Thomas Jouhet, Vianney Aaron, James R. Agapito, Giuseppe Albayrak, Adem Albi, Giuseppe Alessiani, Mario Alloni, Anna Amendola, Danilo F. [UNESP] Angoulvant, François Anthony, Li L.L.J. Aronow, Bruce J. Ashraf, Fatima Atz, Andrew Avillach, Paul Panickan, Vidul Ayakulangara Azevedo, Paula S. [UNESP] Balshi, James Batugo, Ashley Beaulieu-Jones, Brett K. Beau-Lieu-Jones, Brendin R. Bell, Douglas S. Bellasi, Antonio Bellazzi, Riccardo Benoit, Vincent Beraghi, Michele Bernal-Sobrino, José Luis Bernaux, Mélodie Bey, Romain Bhatnagar, Surbhi Blanco-Martínez, Alvar Boeker, Martin Bonzel, Clara-Lea Booth, John Bosari, Silvano Bourgeois, Florence T. Bradford, Robert L. Brat, Gabriel A. Bréant, Stéphane Brown, Nicholas W. Bruno, Raffaele Bryant, William A. Bucalo, Mauro Bucholz, Emily Burgun, Anita Cai, Tianxi Cannataro, Mario Carmona, Aldo Cattelan, Anna Maria Caucheteux, Charlotte Champ, Julien Chen, Krista Y. Chen, Jin Chiovato, Luca Chiudinelli, Lorenzo Cho, Kelly Cimino, James J. Colicchio, Tiago K. Cormont, Sylvie Cossin, Sébastien Craig, Jean B. Cruz-Bermúdez, Juan Luis Cruz-Rojo, Jaime Dagliati, Arianna Daniar, Mohamad Daniel, Christel Das, Priyam Devkota, Batsal Dionne, Audrey Duan, Rui Dubiel, Julien DuVall, Scott L. Esteve, Loic Estiri, Hossein Fan, Shirley Follett, Robert W. Ganslandt, Thomas García-Barrio, Noelia Garmire, Lana X. Gehlenborg, Nils Getzen, Emily J. Geva, Alon González, Tomás González Gradinger, Tobias Gramfort, Alexandre Griffier, Romain Griffon, Nicolas Grisel, Olivier Gutiérrez-Sacristán, Alba Guzzi, Pietro H. Han, Larry Hanauer, David A. Haverkamp, Christian Hazard, Derek Y. He, Bing Henderson, Darren W. Hilka, Martin Ho, Yuk-Lam Holmes, John H. Honerlaw, Jacqueline P. Hong, Chuan Huling, Kenneth M. Hutch, Meghan R. Issitt, Richard W. Jannot, Anne Sophie Kavuluru, Ramakanth Keller, Mark S. Kennedy, Chris J. Kernan, Kate F. Key, Daniel A. Kirchoff, Katie Klann, Jeffrey G. Kohane, Isaac S. Krantz, Ian D. Dr, Detlef Kraska Krishnamurthy, Ashok K. L’Yi, Sehi Le, Trang T. Leblanc, Judith Lemaitre, Guillaume Lenert, Leslie Leprovost, Damien Liu, Molei Loh, Ne Hooi Will Long, Qi Lozano-Zahonero, Sara Luo, Yuan Lynch, Kristine E. Mahmood, Sadiqa Maidlow, Sarah E. Makoudjou, Adeline Makwana, Simran Malovini, Alberto Mandl, Kenneth D. Mao, Chengsheng Maram, Anupama Maripuri, Monika Martel, Patricia Martins, Marcelo R. [UNESP] Marwaha, Jayson S. Masino, Aaron J. Mazzitelli, Maria Mazzotti, Diego R. Mensch, Arthur Milano, Marianna Minicucci, Marcos F. [UNESP] Moal, Bertrand Ahooyi, Taha Mohseni Moore, Jason H. Moraleda, Cinta Morris, Jeffrey S. Morris, Michele Moshal, Karyn L. Mousavi, Sajad Mowery, Danielle L. Murad, Douglas A. Murphy, Shawn N. Naughton, Thomas P. Neto, Carlos Tadeu Breda [UNESP] Neuraz, Antoine Newburger, Jane Ngiam, Kee Yuan Njoroge, Wanjiku F.M. Norman, James B. Obeid, Jihad Okoshi, Marina P. [UNESP] Olson, Karen L. Omenn, Gilbert S. Orlova, Nina Ostasiewski, Brian D. Palmer, Nathan P. Paris, Nicolas Patel, Lav P. Pedrera-Jiménez, Miguel Pfaff, Ashley C. Pfaff, Emily R. Pillion, Danielle Pizzimenti, Sara Priya, Tanu Prokosch, Hans U. Prudente, Robson A. [UNESP] Prunotto, Andrea Quirós-González, Víctor Ramoni, Rachel B. Raskin, Maryna Rieg, Siegbert Roig-Domínguez, Gustavo Rojo, Pablo Rubio-Mayo, Paula Sacchi, Paolo Sáez, Carlos Salamanca, Elisa Samayamuthu, Malarkodi Jebathilagam Sanchez-Pinto, L. Nelson Sandrin, Arnaud Santhanam, Nandhini Santos, Janaina C.C. [UNESP] Sanz Vidorreta, Fernando J. Savino, Maria Schriver, Emily R. Schubert, Petra Schuettler, Juergen Scudeller, Luigia Sebire, Neil J. Serrano-Balazote, Pablo Serre, Patricia Serret-Larmande, Arnaud Shah, Mohsin Abad, Zahra Shakeri Hossein Silvio, Domenick Sliz, Piotr Son, Jiyeon Sonday, Charles South, Andrew M. Sperotto, Francesca Spiridou, Anastasia Strasser, Zachary H. Tan, Amelia L.M. Tan, Bryce W.Q. Tan, Byorn W.L. Tanni, Suzana E. [UNESP] Taylor, Deanne M. Terriza-Torres, Ana I. Tibollo, Valentina Tippmann, Patric Toh, Emma M.S. Torti, Carlo Trecarichi, Enrico M. Vallejos, Andrew K. Varoquaux, Gael Vella, Margaret E. Verdy, Guillaume Vie, Jill-Jênn Visweswaran, Shyam Vitacca, Michele Wagholikar, Kavishwar B. Waitman, Lemuel R. Wang, Xuan Wassermann, Demian Weber, Griffin M. Wolkewitz, Martin Wong, Scott Xia, Zongqi Xiong, Xin Ye, Ye Yehya, Nadir Yuan, William Zachariasse, Joany M. Zahner, Janet J. Zambelli, Alberto Zhang, Harrison G. Zöller, Daniela Zuccaro, Valentina Zucco, Chiara |
author_role |
author |
author2 |
Ferté, Thomas Jouhet, Vianney Aaron, James R. Agapito, Giuseppe Albayrak, Adem Albi, Giuseppe Alessiani, Mario Alloni, Anna Amendola, Danilo F. [UNESP] Angoulvant, François Anthony, Li L.L.J. Aronow, Bruce J. Ashraf, Fatima Atz, Andrew Avillach, Paul Panickan, Vidul Ayakulangara Azevedo, Paula S. [UNESP] Balshi, James Batugo, Ashley Beaulieu-Jones, Brett K. Beau-Lieu-Jones, Brendin R. Bell, Douglas S. Bellasi, Antonio Bellazzi, Riccardo Benoit, Vincent Beraghi, Michele Bernal-Sobrino, José Luis Bernaux, Mélodie Bey, Romain Bhatnagar, Surbhi Blanco-Martínez, Alvar Boeker, Martin Bonzel, Clara-Lea Booth, John Bosari, Silvano Bourgeois, Florence T. Bradford, Robert L. Brat, Gabriel A. Bréant, Stéphane Brown, Nicholas W. Bruno, Raffaele Bryant, William A. Bucalo, Mauro Bucholz, Emily Burgun, Anita Cai, Tianxi Cannataro, Mario Carmona, Aldo Cattelan, Anna Maria Caucheteux, Charlotte Champ, Julien Chen, Krista Y. Chen, Jin Chiovato, Luca Chiudinelli, Lorenzo Cho, Kelly Cimino, James J. Colicchio, Tiago K. Cormont, Sylvie Cossin, Sébastien Craig, Jean B. Cruz-Bermúdez, Juan Luis Cruz-Rojo, Jaime Dagliati, Arianna Daniar, Mohamad Daniel, Christel Das, Priyam Devkota, Batsal Dionne, Audrey Duan, Rui Dubiel, Julien DuVall, Scott L. Esteve, Loic Estiri, Hossein Fan, Shirley Follett, Robert W. Ganslandt, Thomas García-Barrio, Noelia Garmire, Lana X. Gehlenborg, Nils Getzen, Emily J. Geva, Alon González, Tomás González Gradinger, Tobias Gramfort, Alexandre Griffier, Romain Griffon, Nicolas Grisel, Olivier Gutiérrez-Sacristán, Alba Guzzi, Pietro H. Han, Larry Hanauer, David A. Haverkamp, Christian Hazard, Derek Y. He, Bing Henderson, Darren W. Hilka, Martin Ho, Yuk-Lam Holmes, John H. Honerlaw, Jacqueline P. Hong, Chuan Huling, Kenneth M. Hutch, Meghan R. Issitt, Richard W. Jannot, Anne Sophie Kavuluru, Ramakanth Keller, Mark S. Kennedy, Chris J. Kernan, Kate F. Key, Daniel A. Kirchoff, Katie Klann, Jeffrey G. Kohane, Isaac S. Krantz, Ian D. Dr, Detlef Kraska Krishnamurthy, Ashok K. L’Yi, Sehi Le, Trang T. Leblanc, Judith Lemaitre, Guillaume Lenert, Leslie Leprovost, Damien Liu, Molei Loh, Ne Hooi Will Long, Qi Lozano-Zahonero, Sara Luo, Yuan Lynch, Kristine E. Mahmood, Sadiqa Maidlow, Sarah E. Makoudjou, Adeline Makwana, Simran Malovini, Alberto Mandl, Kenneth D. Mao, Chengsheng Maram, Anupama Maripuri, Monika Martel, Patricia Martins, Marcelo R. [UNESP] Marwaha, Jayson S. Masino, Aaron J. Mazzitelli, Maria Mazzotti, Diego R. Mensch, Arthur Milano, Marianna Minicucci, Marcos F. [UNESP] Moal, Bertrand Ahooyi, Taha Mohseni Moore, Jason H. Moraleda, Cinta Morris, Jeffrey S. Morris, Michele Moshal, Karyn L. Mousavi, Sajad Mowery, Danielle L. Murad, Douglas A. Murphy, Shawn N. Naughton, Thomas P. Neto, Carlos Tadeu Breda [UNESP] Neuraz, Antoine Newburger, Jane Ngiam, Kee Yuan Njoroge, Wanjiku F.M. Norman, James B. Obeid, Jihad Okoshi, Marina P. [UNESP] Olson, Karen L. Omenn, Gilbert S. Orlova, Nina Ostasiewski, Brian D. Palmer, Nathan P. Paris, Nicolas Patel, Lav P. Pedrera-Jiménez, Miguel Pfaff, Ashley C. Pfaff, Emily R. Pillion, Danielle Pizzimenti, Sara Priya, Tanu Prokosch, Hans U. Prudente, Robson A. [UNESP] Prunotto, Andrea Quirós-González, Víctor Ramoni, Rachel B. Raskin, Maryna Rieg, Siegbert Roig-Domínguez, Gustavo Rojo, Pablo Rubio-Mayo, Paula Sacchi, Paolo Sáez, Carlos Salamanca, Elisa Samayamuthu, Malarkodi Jebathilagam Sanchez-Pinto, L. Nelson Sandrin, Arnaud Santhanam, Nandhini Santos, Janaina C.C. [UNESP] Sanz Vidorreta, Fernando J. Savino, Maria Schriver, Emily R. Schubert, Petra Schuettler, Juergen Scudeller, Luigia Sebire, Neil J. Serrano-Balazote, Pablo Serre, Patricia Serret-Larmande, Arnaud Shah, Mohsin Abad, Zahra Shakeri Hossein Silvio, Domenick Sliz, Piotr Son, Jiyeon Sonday, Charles South, Andrew M. Sperotto, Francesca Spiridou, Anastasia Strasser, Zachary H. Tan, Amelia L.M. Tan, Bryce W.Q. Tan, Byorn W.L. Tanni, Suzana E. [UNESP] Taylor, Deanne M. Terriza-Torres, Ana I. Tibollo, Valentina Tippmann, Patric Toh, Emma M.S. Torti, Carlo Trecarichi, Enrico M. Vallejos, Andrew K. Varoquaux, Gael Vella, Margaret E. Verdy, Guillaume Vie, Jill-Jênn Visweswaran, Shyam Vitacca, Michele Wagholikar, Kavishwar B. Waitman, Lemuel R. Wang, Xuan Wassermann, Demian Weber, Griffin M. Wolkewitz, Martin Wong, Scott Xia, Zongqi Xiong, Xin Ye, Ye Yehya, Nadir Yuan, William Zachariasse, Joany M. Zahner, Janet J. Zambelli, Alberto Zhang, Harrison G. Zöller, Daniela Zuccaro, Valentina Zucco, Chiara |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Bordeaux University Hospital University of Bordeaux University of Kentucky University Magna Graecia of Catanzaro INC. University of Pavia Lombardia Region Health System BIOMERIS (BIOMedical Research Informatics Solutions) Universidade Estadual Paulista (UNESP) Assistance Public-Hôpitaux de Paris Tan Tock Seng Hospital University of Cincinnati School of Biomedical Informatics Medical University of South Carolina Harvard Medical School St. Luke’s University Health Network Perelman School of Medicine David Geffen School of Medicine at UCLA Ente Ospedaliero Cantonale APHP Greater Paris University Hospital ASST Pavia Hospital Universitario 12 de Octubre Cincinnati Children’s Hospital Medical Center Technical University of Munich Great Ormond Street Hospital for Children IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano UNC Chapel Hill Fondazione I.R.C.C.S. Policlinico San Matteo APHP Greater Paris-University Hospital Padua University Hospital CEA LIRMM Boston-Children’s Hospital Istituti Clinici Scientifici Maugeri SpA SB IRCCS ASST Papa Giovanni XXIII VA Boston Healthcare System University of Alabama at Birmingham ERIAS—Inserm U1219 BPH Boston Children’s Hospital INSERM Children’s Hospital of Philadelphia Harvard T.H. Chan School of Public Health VA Salt Lake City Health Care System Inria Centre de Paris Massachusetts General Hospital University of Michigan Heidelberg University The University of Pennsylvania University of Catanzaro University of Michigan Medical School University of Freiburg Duke University Northwestern University Children’s Hospital of PIttsburgh University Hospital Erlangen Chapel Hill Clevy.io Harvard T. H. Chan School of Public Health National University Health System Beth Israel Deaconess Medical Center University of Kansas-Medical Center PSL University Cedars-Sinai Medical Center University of Pittsburgh University of Paris National University Health System Singapore Wake Forest School of Medicine University Of Kansas Medical Center Northwestern University Feinberg School of Medicine University of Erlangen-Nürnberg Department of Veterans Affairs Faculty of Medicine Universitat Politècnica de València Direction University of Pennsylvania Health System FAU Erlangen-Nürnberg Great Ormond Street Hospital for Children NIHR BRC Paris University University of Toronto University of Pittsburgh Medical Center Wake Forest University School of Medicine National University Hospital The University of Pennsylvania Perelman Medical School National University of Singapore Medical College of Wisconsin McGill University Villeneuved’Ascq ICS S. Maugeri IRCCS Pavia Italy University of Missouri University of Pennsylvania |
dc.contributor.author.fl_str_mv |
Orieux, Arthur Ferté, Thomas Jouhet, Vianney Aaron, James R. Agapito, Giuseppe Albayrak, Adem Albi, Giuseppe Alessiani, Mario Alloni, Anna Amendola, Danilo F. [UNESP] Angoulvant, François Anthony, Li L.L.J. Aronow, Bruce J. Ashraf, Fatima Atz, Andrew Avillach, Paul Panickan, Vidul Ayakulangara Azevedo, Paula S. [UNESP] Balshi, James Batugo, Ashley Beaulieu-Jones, Brett K. Beau-Lieu-Jones, Brendin R. Bell, Douglas S. Bellasi, Antonio Bellazzi, Riccardo Benoit, Vincent Beraghi, Michele Bernal-Sobrino, José Luis Bernaux, Mélodie Bey, Romain Bhatnagar, Surbhi Blanco-Martínez, Alvar Boeker, Martin Bonzel, Clara-Lea Booth, John Bosari, Silvano Bourgeois, Florence T. Bradford, Robert L. Brat, Gabriel A. Bréant, Stéphane Brown, Nicholas W. Bruno, Raffaele Bryant, William A. Bucalo, Mauro Bucholz, Emily Burgun, Anita Cai, Tianxi Cannataro, Mario Carmona, Aldo Cattelan, Anna Maria Caucheteux, Charlotte Champ, Julien Chen, Krista Y. Chen, Jin Chiovato, Luca Chiudinelli, Lorenzo Cho, Kelly Cimino, James J. Colicchio, Tiago K. Cormont, Sylvie Cossin, Sébastien Craig, Jean B. Cruz-Bermúdez, Juan Luis Cruz-Rojo, Jaime Dagliati, Arianna Daniar, Mohamad Daniel, Christel Das, Priyam Devkota, Batsal Dionne, Audrey Duan, Rui Dubiel, Julien DuVall, Scott L. Esteve, Loic Estiri, Hossein Fan, Shirley Follett, Robert W. Ganslandt, Thomas García-Barrio, Noelia Garmire, Lana X. Gehlenborg, Nils Getzen, Emily J. Geva, Alon González, Tomás González Gradinger, Tobias Gramfort, Alexandre Griffier, Romain Griffon, Nicolas Grisel, Olivier Gutiérrez-Sacristán, Alba Guzzi, Pietro H. Han, Larry Hanauer, David A. Haverkamp, Christian Hazard, Derek Y. He, Bing Henderson, Darren W. Hilka, Martin Ho, Yuk-Lam Holmes, John H. Honerlaw, Jacqueline P. Hong, Chuan Huling, Kenneth M. Hutch, Meghan R. Issitt, Richard W. Jannot, Anne Sophie Kavuluru, Ramakanth Keller, Mark S. Kennedy, Chris J. Kernan, Kate F. Key, Daniel A. Kirchoff, Katie Klann, Jeffrey G. Kohane, Isaac S. Krantz, Ian D. Dr, Detlef Kraska Krishnamurthy, Ashok K. L’Yi, Sehi Le, Trang T. Leblanc, Judith Lemaitre, Guillaume Lenert, Leslie Leprovost, Damien Liu, Molei Loh, Ne Hooi Will Long, Qi Lozano-Zahonero, Sara Luo, Yuan Lynch, Kristine E. Mahmood, Sadiqa Maidlow, Sarah E. Makoudjou, Adeline Makwana, Simran Malovini, Alberto Mandl, Kenneth D. Mao, Chengsheng Maram, Anupama Maripuri, Monika Martel, Patricia Martins, Marcelo R. [UNESP] Marwaha, Jayson S. Masino, Aaron J. Mazzitelli, Maria Mazzotti, Diego R. Mensch, Arthur Milano, Marianna Minicucci, Marcos F. [UNESP] Moal, Bertrand Ahooyi, Taha Mohseni Moore, Jason H. Moraleda, Cinta Morris, Jeffrey S. Morris, Michele Moshal, Karyn L. Mousavi, Sajad Mowery, Danielle L. Murad, Douglas A. Murphy, Shawn N. Naughton, Thomas P. Neto, Carlos Tadeu Breda [UNESP] Neuraz, Antoine Newburger, Jane Ngiam, Kee Yuan Njoroge, Wanjiku F.M. Norman, James B. Obeid, Jihad Okoshi, Marina P. [UNESP] Olson, Karen L. Omenn, Gilbert S. Orlova, Nina Ostasiewski, Brian D. Palmer, Nathan P. Paris, Nicolas Patel, Lav P. Pedrera-Jiménez, Miguel Pfaff, Ashley C. Pfaff, Emily R. Pillion, Danielle Pizzimenti, Sara Priya, Tanu Prokosch, Hans U. Prudente, Robson A. [UNESP] Prunotto, Andrea Quirós-González, Víctor Ramoni, Rachel B. Raskin, Maryna Rieg, Siegbert Roig-Domínguez, Gustavo Rojo, Pablo Rubio-Mayo, Paula Sacchi, Paolo Sáez, Carlos Salamanca, Elisa Samayamuthu, Malarkodi Jebathilagam Sanchez-Pinto, L. Nelson Sandrin, Arnaud Santhanam, Nandhini Santos, Janaina C.C. [UNESP] Sanz Vidorreta, Fernando J. Savino, Maria Schriver, Emily R. Schubert, Petra Schuettler, Juergen Scudeller, Luigia Sebire, Neil J. Serrano-Balazote, Pablo Serre, Patricia Serret-Larmande, Arnaud Shah, Mohsin Abad, Zahra Shakeri Hossein Silvio, Domenick Sliz, Piotr Son, Jiyeon Sonday, Charles South, Andrew M. Sperotto, Francesca Spiridou, Anastasia Strasser, Zachary H. Tan, Amelia L.M. Tan, Bryce W.Q. Tan, Byorn W.L. Tanni, Suzana E. [UNESP] Taylor, Deanne M. Terriza-Torres, Ana I. Tibollo, Valentina Tippmann, Patric Toh, Emma M.S. Torti, Carlo Trecarichi, Enrico M. Vallejos, Andrew K. Varoquaux, Gael Vella, Margaret E. Verdy, Guillaume Vie, Jill-Jênn Visweswaran, Shyam Vitacca, Michele Wagholikar, Kavishwar B. Waitman, Lemuel R. Wang, Xuan Wassermann, Demian Weber, Griffin M. Wolkewitz, Martin Wong, Scott Xia, Zongqi Xiong, Xin Ye, Ye Yehya, Nadir Yuan, William Zachariasse, Joany M. Zahner, Janet J. Zambelli, Alberto Zhang, Harrison G. Zöller, Daniela Zuccaro, Valentina Zucco, Chiara |
description |
Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:35:35Z 2023-07-29T13:35:35Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0266985 PLoS ONE, v. 18, n. 1 January, 2023. 1932-6203 http://hdl.handle.net/11449/248141 10.1371/journal.pone.0266985 2-s2.0-85145641542 |
url |
http://dx.doi.org/10.1371/journal.pone.0266985 http://hdl.handle.net/11449/248141 |
identifier_str_mv |
PLoS ONE, v. 18, n. 1 January, 2023. 1932-6203 10.1371/journal.pone.0266985 2-s2.0-85145641542 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS ONE |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965575846297600 |