Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/3796 |
Resumo: | Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL AND METHODS: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. RESULTS: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). CONCLUSIONS: These results demonstrate that the COB cement induces less inflammatory response within long periods. |
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Journal of applied oral science (Online) |
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Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats Calcium hydroxideCastor oilPulp cappingRats Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL AND METHODS: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. RESULTS: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). CONCLUSIONS: These results demonstrate that the COB cement induces less inflammatory response within long periods. Universidade de São Paulo. Faculdade de Odontologia de Bauru2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/379610.1590/S1678-77572010000300014Journal of Applied Oral Science; Vol. 18 No. 3 (2010); 273-278 Journal of Applied Oral Science; Vol. 18 Núm. 3 (2010); 273-278 Journal of Applied Oral Science; v. 18 n. 3 (2010); 273-278 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3796/4486Copyright (c) 2010 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCamargo, Samira Esteves AfonsoRode, Sigmar de MelloPrado, Renata Falchete doCarvalho, Yasmin RodarteCamargo, Carlos Henrique Ribeiro2012-04-27T12:09:26Zoai:revistas.usp.br:article/3796Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:09:26Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
spellingShingle |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats Camargo, Samira Esteves Afonso Calcium hydroxide Castor oil Pulp capping Rats |
title_short |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_full |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_fullStr |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_full_unstemmed |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_sort |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
author |
Camargo, Samira Esteves Afonso |
author_facet |
Camargo, Samira Esteves Afonso Rode, Sigmar de Mello Prado, Renata Falchete do Carvalho, Yasmin Rodarte Camargo, Carlos Henrique Ribeiro |
author_role |
author |
author2 |
Rode, Sigmar de Mello Prado, Renata Falchete do Carvalho, Yasmin Rodarte Camargo, Carlos Henrique Ribeiro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Camargo, Samira Esteves Afonso Rode, Sigmar de Mello Prado, Renata Falchete do Carvalho, Yasmin Rodarte Camargo, Carlos Henrique Ribeiro |
dc.subject.por.fl_str_mv |
Calcium hydroxide Castor oil Pulp capping Rats |
topic |
Calcium hydroxide Castor oil Pulp capping Rats |
description |
Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL AND METHODS: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. RESULTS: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). CONCLUSIONS: These results demonstrate that the COB cement induces less inflammatory response within long periods. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3796 10.1590/S1678-77572010000300014 |
url |
https://www.revistas.usp.br/jaos/article/view/3796 |
identifier_str_mv |
10.1590/S1678-77572010000300014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/3796/4486 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2010 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2010 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 18 No. 3 (2010); 273-278 Journal of Applied Oral Science; Vol. 18 Núm. 3 (2010); 273-278 Journal of Applied Oral Science; v. 18 n. 3 (2010); 273-278 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1787713191694827520 |