Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão

Detalhes bibliográficos
Autor(a) principal: Silva, Antônio Augusto Moura da
Data de Publicação: 2020
Outros Autores: Lima-Neto, Lídio Gonçalves, Azevedo, Conceição de Maria Pedrozo e Silva de, Costa, Léa Márcia Melo da, Bragança, Maylla Luanna Barbosa Martins, Barros Filho, Allan Kardec Duailibe, Wittlin, Bernardo Bastos, Souza, Bruno Feres de, Oliveira, Bruno Luciano Carneiro Alves de, Carvalho, Carolina Abreu de, Thomaz, Erika Barbara Abreu Fonseca, Simões-Neto, Eudes Alves, Leite Júnior, Jamesson Ferreira, Cosme, Lécia Maria Sousa Santos, Campos, Marcos Adriano Garcia, Queiroz, Rejane Christine de Sousa, Costa, Sérgio Souza, Carvalho, Vitória Abreu de, Simões, Vanda Maria Ferreira, Alves, Maria Teresa Seabra Soares de Brito e, Santos, Alcione Miranda dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/180638
Resumo: OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.
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spelling Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in MaranhãoPopulation-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in MaranhãoSeroepidemiologic StudiesCoronavirus InfectionsImmunity, HerdHerdMortalitySeroepidemiologic StudiesCoronavirus InfectionsImmunity, HerdMortalityOBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.Universidade de São Paulo. Faculdade de Saúde Pública2020-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://www.revistas.usp.br/rsp/article/view/18063810.11606/s1518-8787.2020054003278Revista de Saúde Pública; Vol. 54 (2020); 131Revista de Saúde Pública; Vol. 54 (2020); 131Revista de Saúde Pública; v. 54 (2020); 1311518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/180638/167782https://www.revistas.usp.br/rsp/article/view/180638/167783Copyright (c) 2020 Revista de Saúde Públicahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Antônio Augusto Moura daLima-Neto, Lídio GonçalvesAzevedo, Conceição de Maria Pedrozo e Silva deCosta, Léa Márcia Melo daBragança, Maylla Luanna Barbosa MartinsBarros Filho, Allan Kardec DuailibeWittlin, Bernardo BastosSouza, Bruno Feres deOliveira, Bruno Luciano Carneiro Alves deCarvalho, Carolina Abreu deThomaz, Erika Barbara Abreu FonsecaSimões-Neto, Eudes AlvesLeite Júnior, Jamesson FerreiraCosme, Lécia Maria Sousa SantosCampos, Marcos Adriano GarciaQueiroz, Rejane Christine de SousaCosta, Sérgio SouzaCarvalho, Vitória Abreu deSimões, Vanda Maria FerreiraAlves, Maria Teresa Seabra Soares de Brito e Santos, Alcione Miranda dos2021-01-06T19:23:34Zoai:revistas.usp.br:article/180638Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2021-01-06T19:23:34Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
title Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
spellingShingle Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
Silva, Antônio Augusto Moura da
Seroepidemiologic Studies
Coronavirus Infections
Immunity, Herd
HerdMortality
Seroepidemiologic Studies
Coronavirus Infections
Immunity, Herd
Mortality
title_short Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
title_full Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
title_fullStr Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
title_full_unstemmed Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
title_sort Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
author Silva, Antônio Augusto Moura da
author_facet Silva, Antônio Augusto Moura da
Lima-Neto, Lídio Gonçalves
Azevedo, Conceição de Maria Pedrozo e Silva de
Costa, Léa Márcia Melo da
Bragança, Maylla Luanna Barbosa Martins
Barros Filho, Allan Kardec Duailibe
Wittlin, Bernardo Bastos
Souza, Bruno Feres de
Oliveira, Bruno Luciano Carneiro Alves de
Carvalho, Carolina Abreu de
Thomaz, Erika Barbara Abreu Fonseca
Simões-Neto, Eudes Alves
Leite Júnior, Jamesson Ferreira
Cosme, Lécia Maria Sousa Santos
Campos, Marcos Adriano Garcia
Queiroz, Rejane Christine de Sousa
Costa, Sérgio Souza
Carvalho, Vitória Abreu de
Simões, Vanda Maria Ferreira
Alves, Maria Teresa Seabra Soares de Brito e
Santos, Alcione Miranda dos
author_role author
author2 Lima-Neto, Lídio Gonçalves
Azevedo, Conceição de Maria Pedrozo e Silva de
Costa, Léa Márcia Melo da
Bragança, Maylla Luanna Barbosa Martins
Barros Filho, Allan Kardec Duailibe
Wittlin, Bernardo Bastos
Souza, Bruno Feres de
Oliveira, Bruno Luciano Carneiro Alves de
Carvalho, Carolina Abreu de
Thomaz, Erika Barbara Abreu Fonseca
Simões-Neto, Eudes Alves
Leite Júnior, Jamesson Ferreira
Cosme, Lécia Maria Sousa Santos
Campos, Marcos Adriano Garcia
Queiroz, Rejane Christine de Sousa
Costa, Sérgio Souza
Carvalho, Vitória Abreu de
Simões, Vanda Maria Ferreira
Alves, Maria Teresa Seabra Soares de Brito e
Santos, Alcione Miranda dos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Antônio Augusto Moura da
Lima-Neto, Lídio Gonçalves
Azevedo, Conceição de Maria Pedrozo e Silva de
Costa, Léa Márcia Melo da
Bragança, Maylla Luanna Barbosa Martins
Barros Filho, Allan Kardec Duailibe
Wittlin, Bernardo Bastos
Souza, Bruno Feres de
Oliveira, Bruno Luciano Carneiro Alves de
Carvalho, Carolina Abreu de
Thomaz, Erika Barbara Abreu Fonseca
Simões-Neto, Eudes Alves
Leite Júnior, Jamesson Ferreira
Cosme, Lécia Maria Sousa Santos
Campos, Marcos Adriano Garcia
Queiroz, Rejane Christine de Sousa
Costa, Sérgio Souza
Carvalho, Vitória Abreu de
Simões, Vanda Maria Ferreira
Alves, Maria Teresa Seabra Soares de Brito e
Santos, Alcione Miranda dos
dc.subject.por.fl_str_mv Seroepidemiologic Studies
Coronavirus Infections
Immunity, Herd
HerdMortality
Seroepidemiologic Studies
Coronavirus Infections
Immunity, Herd
Mortality
topic Seroepidemiologic Studies
Coronavirus Infections
Immunity, Herd
HerdMortality
Seroepidemiologic Studies
Coronavirus Infections
Immunity, Herd
Mortality
description OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/180638
10.11606/s1518-8787.2020054003278
url https://www.revistas.usp.br/rsp/article/view/180638
identifier_str_mv 10.11606/s1518-8787.2020054003278
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/180638/167782
https://www.revistas.usp.br/rsp/article/view/180638/167783
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista de Saúde Pública
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista de Saúde Pública
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/xml
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 54 (2020); 131
Revista de Saúde Pública; Vol. 54 (2020); 131
Revista de Saúde Pública; v. 54 (2020); 131
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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