Finasteride-associated male infertility

Detalhes bibliográficos
Autor(a) principal: Glina,Sidney
Data de Publicação: 2004
Outros Autores: Neves,Paulo Augusto, Saade,Ricardo, Netto Jr.,Nelson Rodrigues, Soares,Jonathas Borges, Galuppo,Andrea Giannotti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Hospital das Clínicas
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812004000400009
Resumo: Finasteride is a potent and specific inhibitor of the 5alpha-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of finasteride, especially in young fertile patients, because of its action on testosterone metabolism. This paper describes 3 cases of young patients who had very poor seminal quality during finasteride treatment (1 mg/day), and their seminal quality greatly improved after cessation of finasteride treatment. Two of them presented with a left varicocele and the other was obese. We hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasteride could occur. Future studies should be done to clarify the extent of the effect of finasteride in patients fertility problems.
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spelling Finasteride-associated male infertilityFinasterideFertilitySpermatogenesisSpermSeminal parametersFinasteride is a potent and specific inhibitor of the 5alpha-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of finasteride, especially in young fertile patients, because of its action on testosterone metabolism. This paper describes 3 cases of young patients who had very poor seminal quality during finasteride treatment (1 mg/day), and their seminal quality greatly improved after cessation of finasteride treatment. Two of them presented with a left varicocele and the other was obese. We hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasteride could occur. Future studies should be done to clarify the extent of the effect of finasteride in patients fertility problems.Faculdade de Medicina / Universidade de São Paulo - FM/USP2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812004000400009Revista do Hospital das Clínicas v.59 n.4 2004reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812004000400009info:eu-repo/semantics/openAccessGlina,SidneyNeves,Paulo AugustoSaade,RicardoNetto Jr.,Nelson RodriguesSoares,Jonathas BorgesGaluppo,Andrea Giannottieng2004-09-09T00:00:00Zoai:scielo:S0041-87812004000400009Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2004-09-09T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Finasteride-associated male infertility
title Finasteride-associated male infertility
spellingShingle Finasteride-associated male infertility
Glina,Sidney
Finasteride
Fertility
Spermatogenesis
Sperm
Seminal parameters
title_short Finasteride-associated male infertility
title_full Finasteride-associated male infertility
title_fullStr Finasteride-associated male infertility
title_full_unstemmed Finasteride-associated male infertility
title_sort Finasteride-associated male infertility
author Glina,Sidney
author_facet Glina,Sidney
Neves,Paulo Augusto
Saade,Ricardo
Netto Jr.,Nelson Rodrigues
Soares,Jonathas Borges
Galuppo,Andrea Giannotti
author_role author
author2 Neves,Paulo Augusto
Saade,Ricardo
Netto Jr.,Nelson Rodrigues
Soares,Jonathas Borges
Galuppo,Andrea Giannotti
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Glina,Sidney
Neves,Paulo Augusto
Saade,Ricardo
Netto Jr.,Nelson Rodrigues
Soares,Jonathas Borges
Galuppo,Andrea Giannotti
dc.subject.por.fl_str_mv Finasteride
Fertility
Spermatogenesis
Sperm
Seminal parameters
topic Finasteride
Fertility
Spermatogenesis
Sperm
Seminal parameters
description Finasteride is a potent and specific inhibitor of the 5alpha-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of finasteride, especially in young fertile patients, because of its action on testosterone metabolism. This paper describes 3 cases of young patients who had very poor seminal quality during finasteride treatment (1 mg/day), and their seminal quality greatly improved after cessation of finasteride treatment. Two of them presented with a left varicocele and the other was obese. We hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasteride could occur. Future studies should be done to clarify the extent of the effect of finasteride in patients fertility problems.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812004000400009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812004000400009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0041-87812004000400009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
dc.source.none.fl_str_mv Revista do Hospital das Clínicas v.59 n.4 2004
reponame:Revista do Hospital das Clínicas
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista do Hospital das Clínicas
collection Revista do Hospital das Clínicas
repository.name.fl_str_mv Revista do Hospital das Clínicas - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revista.hc@hcnet.usp.br
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