A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500605 |
Resumo: | Abstract This study aimed to investigate the effects of the combined injectable contraceptive (CIC) containing estradiol valerate (EV) and norethisterone enanthate (NET-EN) on aorta function and morphology, as well as on redox status, of female Wistar rats. Female rats (9-10 weeks of age) received intramuscular injections of CIC (0.1 mg EV plus 1 mg NET-EN) or castor oil (control group, CTL) for 8 weeks, once a week. Food intake, body weight and systolic blood pressure were measured during the treatment period. Thoracic aortic segments were prepared for isometric tension recording and morphological analysis. Redox status was evaluated by total oxidant status (TOS) and lipid peroxidation (LP) on plasma and reduced glutathione (GSH) on whole blood. CIC group presented lower food intake and lower total weight gain compared to CTL group. There was no change in systolic blood pressure, vascular response of aorta to phenylephrine and acetylcholine and aorta thickness. Plasma TOS and LP values were reduced in CIC group, although GSH was not altered. It was shown that the long-term treatment with the CIC containing EV plus NET-EN does not induce endothelial dysfunction and histomorphometric changes of vascular wall, as well as improves redox status on female Wistar rats. |
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A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female ratscombined injectable contraceptiveestradiol valeratenorethisterone enanthateoxidative stressvascular morphologyvascular reactivityAbstract This study aimed to investigate the effects of the combined injectable contraceptive (CIC) containing estradiol valerate (EV) and norethisterone enanthate (NET-EN) on aorta function and morphology, as well as on redox status, of female Wistar rats. Female rats (9-10 weeks of age) received intramuscular injections of CIC (0.1 mg EV plus 1 mg NET-EN) or castor oil (control group, CTL) for 8 weeks, once a week. Food intake, body weight and systolic blood pressure were measured during the treatment period. Thoracic aortic segments were prepared for isometric tension recording and morphological analysis. Redox status was evaluated by total oxidant status (TOS) and lipid peroxidation (LP) on plasma and reduced glutathione (GSH) on whole blood. CIC group presented lower food intake and lower total weight gain compared to CTL group. There was no change in systolic blood pressure, vascular response of aorta to phenylephrine and acetylcholine and aorta thickness. Plasma TOS and LP values were reduced in CIC group, although GSH was not altered. It was shown that the long-term treatment with the CIC containing EV plus NET-EN does not induce endothelial dysfunction and histomorphometric changes of vascular wall, as well as improves redox status on female Wistar rats.Academia Brasileira de Ciências2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500605Anais da Academia Brasileira de Ciências v.93 n.3 2021reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202120201924info:eu-repo/semantics/openAccessNERY,LUDMILLA C. DO ESPÍRITO SANTOBRAZ,LESLIE C.S.FERREIRA,LETICIA L.D.M.VIEIRA,FLÁVIA P.SILVA,LEANDRO L. DABLANC,HELENE N.H.RAIMUNDO,JULIANA M.eng2021-08-10T00:00:00Zoai:scielo:S0001-37652021000500605Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2021-08-10T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
title |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
spellingShingle |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats NERY,LUDMILLA C. DO ESPÍRITO SANTO combined injectable contraceptive estradiol valerate norethisterone enanthate oxidative stress vascular morphology vascular reactivity |
title_short |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
title_full |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
title_fullStr |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
title_full_unstemmed |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
title_sort |
A combined injectable contraceptive improves plasma redox status and does not induce vascular changes in female rats |
author |
NERY,LUDMILLA C. DO ESPÍRITO SANTO |
author_facet |
NERY,LUDMILLA C. DO ESPÍRITO SANTO BRAZ,LESLIE C.S. FERREIRA,LETICIA L.D.M. VIEIRA,FLÁVIA P. SILVA,LEANDRO L. DA BLANC,HELENE N.H. RAIMUNDO,JULIANA M. |
author_role |
author |
author2 |
BRAZ,LESLIE C.S. FERREIRA,LETICIA L.D.M. VIEIRA,FLÁVIA P. SILVA,LEANDRO L. DA BLANC,HELENE N.H. RAIMUNDO,JULIANA M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
NERY,LUDMILLA C. DO ESPÍRITO SANTO BRAZ,LESLIE C.S. FERREIRA,LETICIA L.D.M. VIEIRA,FLÁVIA P. SILVA,LEANDRO L. DA BLANC,HELENE N.H. RAIMUNDO,JULIANA M. |
dc.subject.por.fl_str_mv |
combined injectable contraceptive estradiol valerate norethisterone enanthate oxidative stress vascular morphology vascular reactivity |
topic |
combined injectable contraceptive estradiol valerate norethisterone enanthate oxidative stress vascular morphology vascular reactivity |
description |
Abstract This study aimed to investigate the effects of the combined injectable contraceptive (CIC) containing estradiol valerate (EV) and norethisterone enanthate (NET-EN) on aorta function and morphology, as well as on redox status, of female Wistar rats. Female rats (9-10 weeks of age) received intramuscular injections of CIC (0.1 mg EV plus 1 mg NET-EN) or castor oil (control group, CTL) for 8 weeks, once a week. Food intake, body weight and systolic blood pressure were measured during the treatment period. Thoracic aortic segments were prepared for isometric tension recording and morphological analysis. Redox status was evaluated by total oxidant status (TOS) and lipid peroxidation (LP) on plasma and reduced glutathione (GSH) on whole blood. CIC group presented lower food intake and lower total weight gain compared to CTL group. There was no change in systolic blood pressure, vascular response of aorta to phenylephrine and acetylcholine and aorta thickness. Plasma TOS and LP values were reduced in CIC group, although GSH was not altered. It was shown that the long-term treatment with the CIC containing EV plus NET-EN does not induce endothelial dysfunction and histomorphometric changes of vascular wall, as well as improves redox status on female Wistar rats. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500605 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500605 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202120201924 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.93 n.3 2021 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302870415474688 |