Biological functions of selenium and its potential influence on Parkinson's disease
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501655 |
Resumo: | ABSTRACT Parkinson's disease is characterized by the death of dopaminergic neurons, mainly in the substantia nigra, and causes serious locomotor dysfunctions. It is likely that the oxidative damage to cellular biomolecules is among the leading causes of neurodegeneration that occurs in the disease. Selenium is an essential mineral for proper functioning of the brain, and mainly due to its antioxidant activity, it is possible to exert a special role in the prevention and in the nutritional management of Parkinson's disease. Currently, few researchers have investigated the effects of selenium on Parkinson´s disease. However, it is known that very high or very low body levels of selenium can (possibly) contribute to the pathogenesis of Parkinson's disease, because this imbalance results in increased levels of oxidative stress. Therefore, the aim of this work is to review and discuss studies that have addressed these topics and to finally associate the information obtained from them so that these data and associations serve as input to new research. |
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Biological functions of selenium and its potential influence on Parkinson's diseaseneurodegenerationnutritionoxidative stressParkinson's diseaseseleniumABSTRACT Parkinson's disease is characterized by the death of dopaminergic neurons, mainly in the substantia nigra, and causes serious locomotor dysfunctions. It is likely that the oxidative damage to cellular biomolecules is among the leading causes of neurodegeneration that occurs in the disease. Selenium is an essential mineral for proper functioning of the brain, and mainly due to its antioxidant activity, it is possible to exert a special role in the prevention and in the nutritional management of Parkinson's disease. Currently, few researchers have investigated the effects of selenium on Parkinson´s disease. However, it is known that very high or very low body levels of selenium can (possibly) contribute to the pathogenesis of Parkinson's disease, because this imbalance results in increased levels of oxidative stress. Therefore, the aim of this work is to review and discuss studies that have addressed these topics and to finally associate the information obtained from them so that these data and associations serve as input to new research.Academia Brasileira de Ciências2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501655Anais da Academia Brasileira de Ciências v.88 n.3 suppl.0 2016reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201620150595info:eu-repo/semantics/openAccessELLWANGER,JOEL H.FRANKE,SILVIA I.R.BORDIN,DIANA L.PRÁ,DANIELHENRIQUES,JOÃO A.P.eng2016-11-21T00:00:00Zoai:scielo:S0001-37652016000501655Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2016-11-21T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Biological functions of selenium and its potential influence on Parkinson's disease |
title |
Biological functions of selenium and its potential influence on Parkinson's disease |
spellingShingle |
Biological functions of selenium and its potential influence on Parkinson's disease ELLWANGER,JOEL H. neurodegeneration nutrition oxidative stress Parkinson's disease selenium |
title_short |
Biological functions of selenium and its potential influence on Parkinson's disease |
title_full |
Biological functions of selenium and its potential influence on Parkinson's disease |
title_fullStr |
Biological functions of selenium and its potential influence on Parkinson's disease |
title_full_unstemmed |
Biological functions of selenium and its potential influence on Parkinson's disease |
title_sort |
Biological functions of selenium and its potential influence on Parkinson's disease |
author |
ELLWANGER,JOEL H. |
author_facet |
ELLWANGER,JOEL H. FRANKE,SILVIA I.R. BORDIN,DIANA L. PRÁ,DANIEL HENRIQUES,JOÃO A.P. |
author_role |
author |
author2 |
FRANKE,SILVIA I.R. BORDIN,DIANA L. PRÁ,DANIEL HENRIQUES,JOÃO A.P. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
ELLWANGER,JOEL H. FRANKE,SILVIA I.R. BORDIN,DIANA L. PRÁ,DANIEL HENRIQUES,JOÃO A.P. |
dc.subject.por.fl_str_mv |
neurodegeneration nutrition oxidative stress Parkinson's disease selenium |
topic |
neurodegeneration nutrition oxidative stress Parkinson's disease selenium |
description |
ABSTRACT Parkinson's disease is characterized by the death of dopaminergic neurons, mainly in the substantia nigra, and causes serious locomotor dysfunctions. It is likely that the oxidative damage to cellular biomolecules is among the leading causes of neurodegeneration that occurs in the disease. Selenium is an essential mineral for proper functioning of the brain, and mainly due to its antioxidant activity, it is possible to exert a special role in the prevention and in the nutritional management of Parkinson's disease. Currently, few researchers have investigated the effects of selenium on Parkinson´s disease. However, it is known that very high or very low body levels of selenium can (possibly) contribute to the pathogenesis of Parkinson's disease, because this imbalance results in increased levels of oxidative stress. Therefore, the aim of this work is to review and discuss studies that have addressed these topics and to finally associate the information obtained from them so that these data and associations serve as input to new research. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501655 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501655 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201620150595 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.88 n.3 suppl.0 2016 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302863143600128 |