Triorganotin as a compound with potential reproductive toxicity in mammals

Detalhes bibliográficos
Autor(a) principal: Delgado Filho,V.S.
Data de Publicação: 2011
Outros Autores: Lopes,P.F.I., Podratz,P.L., Graceli,J.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018
Resumo: Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.
id ABDC-1_67238090dd8f5cff70939cede5d0ad5e
oai_identifier_str oai:scielo:S0100-879X2011000900018
network_acronym_str ABDC-1
network_name_str Brazilian Journal of Medical and Biological Research
repository_id_str
spelling Triorganotin as a compound with potential reproductive toxicity in mammalsTributyltinTriphenyltinEndocrine disruptorAromataseImposexMammalian reproductive organsOrganotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.Associação Brasileira de Divulgação Científica2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018Brazilian Journal of Medical and Biological Research v.44 n.9 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500110info:eu-repo/semantics/openAccessDelgado Filho,V.S.Lopes,P.F.I.Podratz,P.L.Graceli,J.B.eng2011-09-30T00:00:00Zoai:scielo:S0100-879X2011000900018Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-09-30T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Triorganotin as a compound with potential reproductive toxicity in mammals
title Triorganotin as a compound with potential reproductive toxicity in mammals
spellingShingle Triorganotin as a compound with potential reproductive toxicity in mammals
Delgado Filho,V.S.
Tributyltin
Triphenyltin
Endocrine disruptor
Aromatase
Imposex
Mammalian reproductive organs
title_short Triorganotin as a compound with potential reproductive toxicity in mammals
title_full Triorganotin as a compound with potential reproductive toxicity in mammals
title_fullStr Triorganotin as a compound with potential reproductive toxicity in mammals
title_full_unstemmed Triorganotin as a compound with potential reproductive toxicity in mammals
title_sort Triorganotin as a compound with potential reproductive toxicity in mammals
author Delgado Filho,V.S.
author_facet Delgado Filho,V.S.
Lopes,P.F.I.
Podratz,P.L.
Graceli,J.B.
author_role author
author2 Lopes,P.F.I.
Podratz,P.L.
Graceli,J.B.
author2_role author
author
author
dc.contributor.author.fl_str_mv Delgado Filho,V.S.
Lopes,P.F.I.
Podratz,P.L.
Graceli,J.B.
dc.subject.por.fl_str_mv Tributyltin
Triphenyltin
Endocrine disruptor
Aromatase
Imposex
Mammalian reproductive organs
topic Tributyltin
Triphenyltin
Endocrine disruptor
Aromatase
Imposex
Mammalian reproductive organs
description Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2011007500110
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.44 n.9 2011
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
_version_ 1754302940287336448

Registros relacionados